Clinical Practice Guidelines (CPG) on EBMonFHIR
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: Mortality Outcome for Dexamethasone application - JSON Representation

Active as of 2024-05-15

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{
  "resourceType" : "Evidence",
  "id" : "DexamethasoneOutcomeMortality",
  "meta" : {
    "profile" : [
      🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-evidence-synthesis"
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Evidence</b><a name=\"DexamethasoneOutcomeMortality\"> </a><a name=\"hcDexamethasoneOutcomeMortality\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceEvidence &quot;DexamethasoneOutcomeMortality&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-outcome-evidence-synthesis.html\">Outcome Evidence Synthesis</a></p></div><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/Evidence/DexamethasoneOutcomeMortality</code></p><p><b>name</b>: ExampleOutcomeEvidence</p><p><b>status</b>: active</p><p><b>date</b>: 2024-05-15 06:48:35+0000</p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>citation</td><td><a href=\"Citation-SystemicCorticosteroidsForTheTreatmentOfCOVID19.html\">Citation/SystemicCorticosteroidsForTheTreatmentOfCOVID19</a> &quot;SystemicCorticosteroidsForTheTreatmentOfCOVID19&quot;</td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: population <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-variable-role.html\">EvidenceVariableRole</a>#population)</span></p><p><b>observed</b>: <a href=\"Group-StudyCohortCorticosteroidsCOVID19.html\">Group/StudyCohortCorticosteroidsCOVID19</a> &quot;StudyCohortCriteriaSystemicCorticosteroidsCOVID19&quot;</p><p><b>intended</b>: <a href=\"EvidenceVariable-StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19.html\">EvidenceVariable/StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</a> &quot;StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19&quot;</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: measured variable <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-variable-role.html\">EvidenceVariableRole</a>#measuredVariable)</span></p><p><b>observed</b>: <a href=\"EvidenceVariable-OutcomeAllCauseMortality.html\">EvidenceVariable/OutcomeAllCauseMortality</a> &quot;AllCauseMortality&quot;</p></blockquote><p><b>synthesisType</b>: not applicable <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-synthesis-type.html\">SynthesisType</a>#NotApplicable)</span></p><blockquote><p><b>statistic</b></p><p><b>description</b>: Relative effect of intervention vs. comparator</p><p><b>statisticType</b>: Relative Risk <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-statistic-type.html\">StatisticStatisticType</a>#C93152)</span></p><p><b>quantity</b>: 0.89</p><h3>SampleSizes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>NumberOfStudies</b></td><td><b>NumberOfParticipants</b></td></tr><tr><td style=\"display: none\">*</td><td>9</td><td>7930</td></tr></table><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>Confidence interval <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-attribute-estimate-type.html\">StatisticAttribute Estimate Type</a>#C53324)</span></td><td>0.95</td><td>0.8-1</td></tr></table></blockquote><blockquote><p><b>statistic</b></p><p><b>description</b>: Baseline risk/result in the comparison group</p><p><b>statisticType</b>: Incidence <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-statistic-type.html\">StatisticStatisticType</a>#C16726)</span></p><p><b>quantity</b>: 245 1/1000<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code 1/1000 = '1/1000')</span></p></blockquote></div>"
  },
  "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/Evidence/DexamethasoneOutcomeMortality",
  "name" : "ExampleOutcomeEvidence",
  "status" : "active",
  "date" : "2024-05-15T06:48:35+00:00",
  "relatedArtifact" : [
    {
      "type" : "citation",
      "resourceReference" : {
        🔗 "reference" : "Citation/SystemicCorticosteroidsForTheTreatmentOfCOVID19"
      }
    }
  ],
  "variableDefinition" : [
    {
      "variableRole" : {
        "coding" : [
          {
            "system" : "http://terminology.hl7.org/CodeSystem/variable-role",
            "code" : "population"
          }
        ]
      },
      "observed" : {
        🔗 "reference" : "Group/StudyCohortCorticosteroidsCOVID19"
      },
      "intended" : {
        🔗 "reference" : "EvidenceVariable/StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"
      }
    },
    {
      "variableRole" : {
        "coding" : [
          {
            "system" : "http://terminology.hl7.org/CodeSystem/variable-role",
            "code" : "measuredVariable"
          }
        ]
      },
      "observed" : {
        🔗 "reference" : "EvidenceVariable/OutcomeAllCauseMortality"
      }
    }
  ],
  "synthesisType" : {
    "coding" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/synthesis-type",
        "code" : "NotApplicable"
      }
    ]
  },
  "statistic" : [
    {
      "description" : "Relative effect of intervention vs. comparator",
      "statisticType" : {
        "coding" : [
          {
            "system" : "http://terminology.hl7.org/CodeSystem/statistic-type",
            "code" : "C93152",
            "display" : "Relative Risk"
          }
        ]
      },
      "quantity" : {
        "value" : 0.89
      },
      "sampleSize" : {
        "numberOfStudies" : 9,
        "numberOfParticipants" : 7930
      },
      "attributeEstimate" : [
        {
          "type" : {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/attribute-estimate-type",
                "code" : "C53324",
                "display" : "Confidence interval"
              }
            ]
          },
          "level" : 0.95,
          "range" : {
            "low" : {
              "value" : 0.8
            },
            "high" : {
              "value" : 1
            }
          }
        }
      ]
    },
    {
      "description" : "Baseline risk/result in the comparison group",
      "statisticType" : {
        "coding" : [
          {
            "system" : "http://terminology.hl7.org/CodeSystem/statistic-type",
            "code" : "C16726",
            "display" : "Incidence"
          }
        ]
      },
      "quantity" : {
        "value" : 245,
        "system" : "http://unitsofmeasure.org",
        "code" : "1/1000"
      }
    }
  ]
}