Clinical Practice Guidelines (CPG) on EBMonFHIR
0.8.0-snapshot - ci-build

Clinical Practice Guidelines (CPG) on EBMonFHIR - Local Development build (v0.8.0-snapshot) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions

: COVID19 Intensive Care Treatment Guideline - JSON Representation

Raw json | Download


{
  "resourceType" : "Bundle",
  "id" : "COVID19IntensiveCareTreatmentGuidelineBundle",
  "meta" : {
    "profile" : [
      🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-bundle"
    ]
  },
  "type" : "collection",
  "entry" : [
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/guideline",
      "resource" : {
        "resourceType" : "Composition",
        "id" : "COVID19IntensiveCareTreatmentGuideline",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Composition_COVID19IntensiveCareTreatmentGuideline\"> </a><p><b>Generated Narrative: Composition</b><a name=\"COVID19IntensiveCareTreatmentGuideline\"> </a><a name=\"hcCOVID19IntensiveCareTreatmentGuideline\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceComposition &quot;COVID19IntensiveCareTreatmentGuideline&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-guideline.html\">Clinical Practice Guideline</a></p></div><p><b>identifier</b>: Resource identifier/113-001</p><p><b>version</b>: 7.0</p><p><b>status</b>: final</p><p><b>type</b>: Guidelines <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-code-system.html\">CEOsys Code System</a>#clinical-practice-guideline; #e07eN1w1Rwswg4)</span></p><p><b>category</b>: Evidence- and consensus-based guideline <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-guideline-stage-classification.html\">Guideline Stage Classification</a>#S3)</span></p><p><b>date</b>: 2022-03-01</p><p><b>author</b>: <a href=\"Organization-AWMFOrganization.html\">Organization/AWMFOrganization</a> &quot;Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) e.V.&quot;</p><p><b>title</b>: Empfehlungen zur stationären Therapie von Patienten mit COVID-19 - Living Guideline</p><h3>RelatesTos</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>citation</td><td>See on this page: Citation/COVID19IntensiveCareTreatmentGuidelineCitation</td></tr></table></div>"
        },
        "identifier" : [
          {
            "type" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                  "code" : "RI",
                  "display" : "Resource identifier"
                }
              ]
            },
            "system" : "https://www.awmf.org/",
            "value" : "113-001"
          }
        ],
        "version" : "7.0",
        "status" : "final",
        "type" : {
          "coding" : [
            {
              "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
              "code" : "clinical-practice-guideline"
            },
            {
              "system" : "https://data.cochrane.org/concepts/",
              "code" : "e07eN1w1Rwswg4",
              "display" : "Guidelines"
            }
          ]
        },
        "category" : [
          {
            "coding" : [
              {
                "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification",
                "code" : "S3",
                "display" : "Evidence- and consensus-based guideline"
              }
            ]
          }
        ],
        "date" : "2022-03-01",
        "author" : [
          {
            🔗 "reference" : "Organization/AWMFOrganization"
          }
        ],
        "title" : "Empfehlungen zur stationären Therapie von Patienten mit COVID-19 - Living Guideline",
        "relatesTo" : [
          {
            "type" : "citation",
            "resourceReference" : {
              🔗 "reference" : "Citation/COVID19IntensiveCareTreatmentGuidelineCitation"
            }
          }
        ],
        "section" : [
          {
            "title" : "Stationäre Therapie von COVID-19 Patienten",
            "code" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code" : "guideline-recommendation",
                  "display" : "Clinical practice guideline recommendation"
                }
              ]
            },
            "focus" : {
              🔗 "reference" : "PlanDefinition/COVID19VentilatedPatientsDexamethasoneApplicationPlan"
            },
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><strong>Systemische Steroide:</strong> Bei Patienten mit COVID-19- und Sauerstoff-Bedarf (Niedrigfluss-Sauerstoff-Insufflation, High-Flow Nasal Cannula, Nichtinvasive Beatmung/CPAP, invasive Beatmung) soll eine Therapie mit systemischen Kortikosteroiden erfolgen. Die Therapie sollte mit 6 mg Dexamethason p.o. oder i.v. über zehn Tage erfolgen.</div>"
            }
          },
          {
            "title" : "Stationäre Therapie von COVID-19 Patienten",
            "code" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code" : "guideline-recommendation",
                  "display" : "Clinical practice guideline recommendation"
                }
              ]
            },
            "focus" : {
              🔗 "reference" : "PlanDefinition/COVID19NonVentilatedPatientsDexamethasoneApplicationPlan"
            },
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><strong>Systemische Steroide:</strong> Bei Patienten mit moderater Erkrankung (hospitalisiert ohne Notwendigkeit von Niedrigfluss-Sauerstoff-Insufflation) soll keine Therapie mit systemischen Kortikosteroiden erfolgen.</div>"
            }
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/guideline-citation",
      "resource" : {
        "resourceType" : "Citation",
        "id" : "COVID19IntensiveCareTreatmentGuidelineCitation",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-citation"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Citation_COVID19IntensiveCareTreatmentGuidelineCitation\"> </a><p><b>Generated Narrative: Citation</b><a name=\"COVID19IntensiveCareTreatmentGuidelineCitation\"> </a><a name=\"hcCOVID19IntensiveCareTreatmentGuidelineCitation\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceCitation &quot;COVID19IntensiveCareTreatmentGuidelineCitation&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-guideline-citation.html\">Guideline Citation</a></p></div><p><b>name</b>: COVID19_Intensive_Care_Treatment_Guideline</p><p><b>status</b>: active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://www.awmf.org/</code>/113-001</p><h3>Versions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Value</b></td></tr><tr><td style=\"display: none\">*</td><td>7.0</td></tr></table><p><b>currentState</b>: Active <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-status-type.html\">Cited Artifact Status Type</a>#active)</span></p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>S3-Leitlinie Stationäre Therapie von COVID-19 Patienten</td></tr></table><h3>WebLocations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://www.awmf.org/leitlinien/detail/ll/113-001.html\">https://www.awmf.org/leitlinien/detail/ll/113-001.html</a></td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>Publication Type <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#publication-type)</span></td><td>Clinical practice guideline <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-code-system.html\">CEOsys Code System</a>#clinical-practice-guideline)</span></td></tr></table></blockquote></div>"
        },
        "name" : "COVID19_Intensive_Care_Treatment_Guideline",
        "status" : "active",
        "citedArtifact" : {
          "identifier" : [
            {
              "system" : "https://www.awmf.org/",
              "value" : "113-001"
            }
          ],
          "version" : {
            "value" : "7.0"
          },
          "currentState" : [
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/cited-artifact-status-type",
                  "code" : "active",
                  "display" : "Active"
                }
              ]
            }
          ],
          "title" : [
            {
              "text" : "S3-Leitlinie Stationäre Therapie von COVID-19 Patienten"
            }
          ],
          "webLocation" : [
            {
              "url" : "https://www.awmf.org/leitlinien/detail/ll/113-001.html"
            }
          ],
          "classification" : [
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                    "code" : "publication-type",
                    "display" : "Publication Type"
                  }
                ]
              },
              "classifier" : [
                {
                  "coding" : [
                    {
                      "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                      "code" : "clinical-practice-guideline",
                      "display" : "Clinical practice guideline"
                    }
                  ]
                }
              ]
            }
          ]
        }
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation",
      "resource" : {
        "resourceType" : "PlanDefinition",
        "id" : "COVID19DexamethasoneApplication",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_COVID19DexamethasoneApplication\"> </a><p><b>Generated Narrative: PlanDefinition</b><a name=\"COVID19DexamethasoneApplication\"> </a><a name=\"hcCOVID19DexamethasoneApplication\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourcePlanDefinition &quot;COVID19DexamethasoneApplication&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation.html\">Recommendation</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><blockquote><p><b>Action Combination Method</b></p><blockquote><p><b>url</b></p><code>method</code></blockquote><p><b>value</b>: One or More <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-action-combination-method.html\">Action Combination Method</a>#one-or-more)</span></p></blockquote><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation</code></p><p><b>version</b>: 4.0</p><p><b>name</b>: Dexamethasone_Application</p><p><b>title</b>: Dexamethasone Application</p><p><b>type</b>: Workflow Definition <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-plan-definition-type.html\">PlanDefinitionType</a>#workflow-definition)</span></p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href=\"EvidenceVariable-PopulationCOVID19Ventilated.html\">Population_COVID19_Ventilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: Application of Dexamethasone for ventilated patients only</p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>justification</td><td>Recommendation rating <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-code-system.html\">CEOsys Code System</a>#recommendation-rating)</span></td><td>See on this page: ArtifactAssessment/DexamethasoneRecommendationJustification</td></tr><tr><td style=\"display: none\">*</td><td>citation</td><td>Clinical practice guideline recommendation <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-code-system.html\">CEOsys Code System</a>#guideline-recommendation)</span></td><td>See on this page: Citation/DexamethasoneRecommendationCitation</td></tr><tr><td style=\"display: none\">*</td><td>citation</td><td>Clinical practice guideline <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-code-system.html\">CEOsys Code System</a>#clinical-practice-guideline)</span></td><td>See on this page: Citation/COVID19IntensiveCareTreatmentGuidelineCitation</td></tr></table><blockquote><p><b>action</b></p><p><b>title</b>: Dexamethasone Application</p><p><b>description</b>: Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients</p><p><b>code</b>: Guideline-based Care <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/cpg/STU1/CodeSystem-cpg-common-process.html\">CPG Common Process</a>#guideline-based-care)</span></p><p><b>definition</b>: <a href=\"PlanDefinition-COVID19VentilatedPatientsDexamethasoneApplicationPlan.html\">Dexamethasone Application in ventilated COVID-19 patients</a></p></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: No Dexamethasone Application</p><p><b>description</b>: No Dexamethasone Application for non-ventilated COVID-19 patients</p><p><b>code</b>: Guideline-based Care <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/uv/cpg/STU1/CodeSystem-cpg-common-process.html\">CPG Common Process</a>#guideline-based-care)</span></p><p><b>definition</b>: <a href=\"PlanDefinition-COVID19NonVentilatedPatientsDexamethasoneApplicationPlan.html\">No Dexamethasone Application for non-ventilated COVID-19 patients</a></p></blockquote></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          },
          {
            "extension" : [
              {
                "url" : "method",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method",
                      "code" : "one-or-more"
                    }
                  ]
                }
              }
            ],
            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation",
        "version" : "4.0",
        "name" : "Dexamethasone_Application",
        "title" : "Dexamethasone Application",
        "type" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
              "code" : "workflow-definition"
            }
          ]
        },
        "status" : "active",
        "experimental" : true,
        "subjectCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated",
        "date" : "2021-12-12",
        "publisher" : "CPGonEBMonFHIR",
        "description" : "Application of Dexamethasone for ventilated patients only",
        "relatedArtifact" : [
          {
            "type" : "justification",
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                    "code" : "recommendation-rating",
                    "display" : "Recommendation rating"
                  }
                ]
              }
            ],
            "resourceReference" : {
              🔗 "reference" : "ArtifactAssessment/DexamethasoneRecommendationJustification"
            }
          },
          {
            "type" : "citation",
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                    "code" : "guideline-recommendation",
                    "display" : "Clinical practice guideline recommendation"
                  }
                ]
              }
            ],
            "resourceReference" : {
              🔗 "reference" : "Citation/DexamethasoneRecommendationCitation"
            }
          },
          {
            "type" : "citation",
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                    "code" : "clinical-practice-guideline",
                    "display" : "Clinical practice guideline"
                  }
                ]
              }
            ],
            "resourceReference" : {
              🔗 "reference" : "Citation/COVID19IntensiveCareTreatmentGuidelineCitation"
            }
          }
        ],
        "action" : [
          {
            "title" : "Dexamethasone Application",
            "description" : "Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients",
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process",
                  "code" : "guideline-based-care"
                }
              ]
            },
            "definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-ventilated-patients-dexamethasone-application-plan"
          },
          {
            "title" : "No Dexamethasone Application",
            "description" : "No Dexamethasone Application for non-ventilated COVID-19 patients",
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process",
                  "code" : "guideline-based-care"
                }
              ]
            },
            "definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-non-ventilated-patients-no-dexamethasone-application-plan"
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-plan-ventilated-patients",
      "resource" : {
        "resourceType" : "PlanDefinition",
        "id" : "COVID19VentilatedPatientsDexamethasoneApplicationPlan",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_COVID19VentilatedPatientsDexamethasoneApplicationPlan\"> </a><p><b>Generated Narrative: PlanDefinition</b><a name=\"COVID19VentilatedPatientsDexamethasoneApplicationPlan\"> </a><a name=\"hcCOVID19VentilatedPatientsDexamethasoneApplicationPlan\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourcePlanDefinition &quot;COVID19VentilatedPatientsDexamethasoneApplicationPlan&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation-plan.html\">Recommendation Plan</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href=\"PlanDefinition-COVID19DexamethasoneApplication.html\">Dexamethasone Application</a></p><blockquote><p><b>Action Combination Method</b></p><blockquote><p><b>url</b></p><code>method</code></blockquote><p><b>value</b>: Exactly <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-action-combination-method.html\">Action Combination Method</a>#exactly)</span></p><blockquote><p><b>url</b></p><code>threshold</code></blockquote><p><b>value</b>: 1</p></blockquote><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-ventilated-patients-dexamethasone-application-plan</code></p><p><b>version</b>: 4.0</p><p><b>name</b>: Dexamethasone_Application</p><p><b>title</b>: Dexamethasone Application in ventilated COVID-19 patients</p><p><b>type</b>: ECA Rule <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-plan-definition-type.html\">PlanDefinitionType</a>#eca-rule)</span></p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href=\"EvidenceVariable-PopulationCOVID19Ventilated.html\">Population_COVID19_Ventilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients</p><blockquote><p><b>action</b></p><p><b>code</b>: Administration of substance (procedure) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#432102000)</span></p><p><b>definition</b>: <a href=\"Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html\">DexamethasoneApplicationActionOral</a></p></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: Administration of substance (procedure) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#432102000)</span></p><p><b>definition</b>: <a href=\"Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html\">DexamethasoneApplicationActionIntravenous</a></p></blockquote></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-partOf",
            "valueCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation"
          },
          {
            "extension" : [
              {
                "url" : "method",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method",
                      "code" : "exactly"
                    }
                  ]
                }
              },
              {
                "url" : "threshold",
                "valuePositiveInt" : 1
              }
            ],
            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-ventilated-patients-dexamethasone-application-plan",
        "version" : "4.0",
        "name" : "Dexamethasone_Application",
        "title" : "Dexamethasone Application in ventilated COVID-19 patients",
        "type" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
              "code" : "eca-rule"
            }
          ]
        },
        "status" : "active",
        "experimental" : true,
        "subjectCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated",
        "date" : "2021-12-12",
        "publisher" : "CPGonEBMonFHIR",
        "description" : "Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients",
        "action" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://snomed.info/sct",
                  "code" : "432102000",
                  "display" : "Administration of substance (procedure)"
                }
              ]
            },
            "definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral"
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://snomed.info/sct",
                  "code" : "432102000",
                  "display" : "Administration of substance (procedure)"
                }
              ]
            },
            "definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous"
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-plan-non-ventilated-patients",
      "resource" : {
        "resourceType" : "PlanDefinition",
        "id" : "COVID19NonVentilatedPatientsDexamethasoneApplicationPlan",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_COVID19NonVentilatedPatientsDexamethasoneApplicationPlan\"> </a><p><b>Generated Narrative: PlanDefinition</b><a name=\"COVID19NonVentilatedPatientsDexamethasoneApplicationPlan\"> </a><a name=\"hcCOVID19NonVentilatedPatientsDexamethasoneApplicationPlan\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourcePlanDefinition &quot;COVID19NonVentilatedPatientsDexamethasoneApplicationPlan&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation-plan.html\">Recommendation Plan</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href=\"PlanDefinition-COVID19DexamethasoneApplication.html\">Dexamethasone Application</a></p><blockquote><p><b>Action Combination Method</b></p><blockquote><p><b>url</b></p><code>method</code></blockquote><p><b>value</b>: Exactly <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-action-combination-method.html\">Action Combination Method</a>#exactly)</span></p><blockquote><p><b>url</b></p><code>threshold</code></blockquote><p><b>value</b>: 1</p></blockquote><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-non-ventilated-patients-no-dexamethasone-application-plan</code></p><p><b>version</b>: 4.0</p><p><b>name</b>: No_Dexamethasone_Application</p><p><b>title</b>: No Dexamethasone Application for non-ventilated COVID-19 patients</p><p><b>type</b>: ECA Rule <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-plan-definition-type.html\">PlanDefinitionType</a>#eca-rule)</span></p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href=\"EvidenceVariable-PopulationCOVID19NonVentilated.html\">Population_COVID19_NonVentilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: No Dexamethasone Application for non-ventilated COVID19 patients</p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Administration of substance (procedure) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#432102000)</span></td><td><a href=\"Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html\">NoDexamethasoneApplicationActivity</a></td></tr></table></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-partOf",
            "valueCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation"
          },
          {
            "extension" : [
              {
                "url" : "method",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method",
                      "code" : "exactly"
                    }
                  ]
                }
              },
              {
                "url" : "threshold",
                "valuePositiveInt" : 1
              }
            ],
            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-non-ventilated-patients-no-dexamethasone-application-plan",
        "version" : "4.0",
        "name" : "No_Dexamethasone_Application",
        "title" : "No Dexamethasone Application for non-ventilated COVID-19 patients",
        "type" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
              "code" : "eca-rule"
            }
          ]
        },
        "status" : "active",
        "experimental" : true,
        "subjectCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_NonVentilated",
        "date" : "2021-12-12",
        "publisher" : "CPGonEBMonFHIR",
        "description" : "No Dexamethasone Application for non-ventilated COVID19 patients",
        "action" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://snomed.info/sct",
                  "code" : "432102000",
                  "display" : "Administration of substance (procedure)"
                }
              ]
            },
            "definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application"
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-oral",
      "resource" : {
        "resourceType" : "ActivityDefinition",
        "id" : "DexamethasoneApplicationActionOral",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ActivityDefinition_DexamethasoneApplicationActionOral\"> </a><p><b>Generated Narrative: ActivityDefinition</b><a name=\"DexamethasoneApplicationActionOral\"> </a><a name=\"hcDexamethasoneApplicationActionOral\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceActivityDefinition &quot;DexamethasoneApplicationActionOral&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-drug-administration-action.html\">Drug Administration Action</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral</code></p><p><b>version</b>: 1.0</p><p><b>name</b>: DexamethasoneApplicationActionOral</p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: Patient <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-fhir-types.html\">All FHIR Types</a>#Patient)</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: Application of Dexamethasone: 6 mg once per day for 10 days (oral route)</p><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: Administration of substance (procedure) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#432102000)</span></p><p><b>product</b>: Dexamethasone (substance) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#372584003; atc#C05AA09 &quot;Dexamethason&quot;)</span></p><blockquote><p><b>dosage</b></p><p><b>timing</b>: Count 10  times, Duration 10days , Once per 1 days</p><p><b>route</b>: Oral route <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#26643006)</span></p><blockquote><p><b>doseAndRate</b></p></blockquote></blockquote></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral",
        "version" : "1.0",
        "name" : "DexamethasoneApplicationActionOral",
        "status" : "active",
        "experimental" : true,
        "subjectCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/fhir-types",
              "code" : "Patient"
            }
          ]
        },
        "publisher" : "CPGonEBMonFHIR",
        "description" : "Application of Dexamethasone: 6 mg once per day for 10 days (oral route)",
        "kind" : "MedicationRequest",
        "code" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "432102000",
              "display" : "Administration of substance (procedure)"
            }
          ]
        },
        "productCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "372584003",
              "display" : "Dexamethasone (substance)"
            },
            {
              "system" : "http://fhir.de/CodeSystem/bfarm/atc",
              "code" : "C05AA09",
              "display" : "Dexamethason"
            }
          ]
        },
        "dosage" : [
          {
            "timing" : {
              "repeat" : {
                "count" : 10,
                "duration" : 10,
                "durationUnit" : "d",
                "frequency" : 1,
                "period" : 1,
                "periodUnit" : "d"
              }
            },
            "route" : {
              "coding" : [
                {
                  "system" : "http://snomed.info/sct",
                  "code" : "26643006",
                  "display" : "Oral route"
                }
              ]
            },
            "doseAndRate" : [
              {
                "doseQuantity" : {
                  "value" : 6,
                  "unit" : "mg",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "mg"
                },
                "rateQuantity" : {
                  "value" : 1,
                  "unit" : "/d",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "/d"
                }
              }
            ]
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-intravenous",
      "resource" : {
        "resourceType" : "ActivityDefinition",
        "id" : "DexamethasoneApplicationActionIntravenous",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ActivityDefinition_DexamethasoneApplicationActionIntravenous\"> </a><p><b>Generated Narrative: ActivityDefinition</b><a name=\"DexamethasoneApplicationActionIntravenous\"> </a><a name=\"hcDexamethasoneApplicationActionIntravenous\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceActivityDefinition &quot;DexamethasoneApplicationActionIntravenous&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-drug-administration-action.html\">Drug Administration Action</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous</code></p><p><b>version</b>: 1.0</p><p><b>name</b>: DexamethasoneApplicationActionIntravenous</p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: Patient <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-fhir-types.html\">All FHIR Types</a>#Patient)</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: Application of Dexamethasone: 6 mg once per day for 10 days (intravenous route)</p><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: Administration of substance (procedure) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#432102000)</span></p><p><b>product</b>: Dexamethasone (substance) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#372584003; atc#C05AA09 &quot;Dexamethason&quot;)</span></p><blockquote><p><b>dosage</b></p><p><b>timing</b>: Count 10  times, Duration 10days , Once per 1 days</p><p><b>route</b>: Intravenous route <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#47625008)</span></p><blockquote><p><b>doseAndRate</b></p></blockquote></blockquote></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous",
        "version" : "1.0",
        "name" : "DexamethasoneApplicationActionIntravenous",
        "status" : "active",
        "experimental" : true,
        "subjectCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/fhir-types",
              "code" : "Patient"
            }
          ]
        },
        "publisher" : "CPGonEBMonFHIR",
        "description" : "Application of Dexamethasone: 6 mg once per day for 10 days (intravenous route)",
        "kind" : "MedicationRequest",
        "code" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "432102000",
              "display" : "Administration of substance (procedure)"
            }
          ]
        },
        "productCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "372584003",
              "display" : "Dexamethasone (substance)"
            },
            {
              "system" : "http://fhir.de/CodeSystem/bfarm/atc",
              "code" : "C05AA09",
              "display" : "Dexamethason"
            }
          ]
        },
        "dosage" : [
          {
            "timing" : {
              "repeat" : {
                "count" : 10,
                "duration" : 10,
                "durationUnit" : "d",
                "frequency" : 1,
                "period" : 1,
                "periodUnit" : "d"
              }
            },
            "route" : {
              "coding" : [
                {
                  "system" : "http://snomed.info/sct",
                  "code" : "47625008",
                  "display" : "Intravenous route"
                }
              ]
            },
            "doseAndRate" : [
              {
                "doseQuantity" : {
                  "value" : 6,
                  "unit" : "mg",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "mg"
                },
                "rateQuantity" : {
                  "value" : 1,
                  "unit" : "/d",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "/d"
                }
              }
            ]
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-no-application",
      "resource" : {
        "resourceType" : "ActivityDefinition",
        "id" : "NoDexamethasoneApplication",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ActivityDefinition_NoDexamethasoneApplication\"> </a><p><b>Generated Narrative: ActivityDefinition</b><a name=\"NoDexamethasoneApplication\"> </a><a name=\"hcNoDexamethasoneApplication\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceActivityDefinition &quot;NoDexamethasoneApplication&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-drug-administration-action.html\">Drug Administration Action</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application</code></p><p><b>version</b>: 1.0</p><p><b>name</b>: NoDexamethasoneApplicationActivity</p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: Patient <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-fhir-types.html\">All FHIR Types</a>#Patient)</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: No Application of Dexamethasone</p><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: Administration of substance (procedure) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#432102000)</span></p><p><b>doNotPerform</b>: true</p><p><b>product</b>: Dexamethasone (substance) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#372584003; atc#C05AA09 &quot;Dexamethason&quot;)</span></p></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application",
        "version" : "1.0",
        "name" : "NoDexamethasoneApplicationActivity",
        "status" : "active",
        "experimental" : true,
        "subjectCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/fhir-types",
              "code" : "Patient"
            }
          ]
        },
        "publisher" : "CPGonEBMonFHIR",
        "description" : "No Application of Dexamethasone",
        "kind" : "MedicationRequest",
        "code" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "432102000",
              "display" : "Administration of substance (procedure)"
            }
          ]
        },
        "doNotPerform" : true,
        "productCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "372584003",
              "display" : "Dexamethasone (substance)"
            },
            {
              "system" : "http://fhir.de/CodeSystem/bfarm/atc",
              "code" : "C05AA09",
              "display" : "Dexamethason"
            }
          ]
        }
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-citation",
      "resource" : {
        "resourceType" : "Citation",
        "id" : "DexamethasoneRecommendationCitation",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-citation"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Citation_DexamethasoneRecommendationCitation\"> </a><p><b>Generated Narrative: Citation</b><a name=\"DexamethasoneRecommendationCitation\"> </a><a name=\"hcDexamethasoneRecommendationCitation\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceCitation &quot;DexamethasoneRecommendationCitation&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation-citation.html\">Recommendation Citation</a></p></div><p><b>name</b>: DexamethasoneRecommendationCitation</p><p><b>status</b>: active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://api.magicapp.org/api/v1/recommendations</code>/98398</p><h3>Versions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Value</b></td></tr><tr><td style=\"display: none\">*</td><td>v4.0</td></tr></table><p><b>currentState</b>: Active <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-status-type.html\">Cited Artifact Status Type</a>#active)</span></p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>Steroide</td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>Publication Type <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#publication-type)</span></td><td>Clinical practice guideline recommendation <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-code-system.html\">CEOsys Code System</a>#guideline-recommendation)</span></td></tr></table></blockquote></div>"
        },
        "name" : "DexamethasoneRecommendationCitation",
        "status" : "active",
        "citedArtifact" : {
          "identifier" : [
            {
              "system" : "https://api.magicapp.org/api/v1/recommendations",
              "value" : "98398"
            }
          ],
          "version" : {
            "value" : "v4.0"
          },
          "currentState" : [
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/cited-artifact-status-type",
                  "code" : "active",
                  "display" : "Active"
                }
              ]
            }
          ],
          "title" : [
            {
              "text" : "Steroide"
            }
          ],
          "classification" : [
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                    "code" : "publication-type",
                    "display" : "Publication Type"
                  }
                ]
              },
              "classifier" : [
                {
                  "coding" : [
                    {
                      "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                      "code" : "guideline-recommendation",
                      "display" : "Clinical practice guideline recommendation"
                    }
                  ]
                }
              ]
            }
          ]
        }
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/evidence-variable-ventilated",
      "resource" : {
        "resourceType" : "EvidenceVariable",
        "id" : "PopulationCOVID19Ventilated",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-eligibility-criteria"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"EvidenceVariable_PopulationCOVID19Ventilated\"> </a><p><b>Generated Narrative: EvidenceVariable</b><a name=\"PopulationCOVID19Ventilated\"> </a><a name=\"hcPopulationCOVID19Ventilated\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceEvidenceVariable &quot;PopulationCOVID19Ventilated&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation-eligibility-criteria.html\">Recommendation Eligibility Criteria</a></p></div><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated</code></p><p><b>identifier</b>: <code>https://www.ceosys.de</code>/Ventilated</p><p><b>name</b>: Population_COVID19_Ventilated</p><p><b>status</b>: active</p><p><b>description</b>: Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, Ventilated</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: covid19</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Clinical finding (finding) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#404684003)</span></td><td>Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#840539006)</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: any-of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: oxy-administration-nasal-cannula</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: noninvasive-ventilation</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: artificial-respiration</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote></blockquote></blockquote></div>"
        },
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated",
        "identifier" : [
          {
            "system" : "https://www.ceosys.de",
            "value" : "Ventilated"
          }
        ],
        "name" : "Population_COVID19_Ventilated",
        "status" : "active",
        "description" : "Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, Ventilated",
        "characteristic" : [
          {
            "linkId" : "covid19",
            "definitionByTypeAndValue" : {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://snomed.info/sct",
                    "code" : "404684003",
                    "display" : "Clinical finding (finding)"
                  }
                ]
              },
              "valueCodeableConcept" : {
                "coding" : [
                  {
                    "system" : "http://snomed.info/sct",
                    "code" : "840539006",
                    "display" : "Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"
                  }
                ]
              }
            }
          },
          {
            "exclude" : false,
            "definitionByCombination" : {
              "code" : "any-of",
              "characteristic" : [
                {
                  "linkId" : "oxy-administration-nasal-cannula",
                  "exclude" : false,
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "71388002",
                          "display" : "Procedure (procedure)"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "371907003",
                          "display" : "Oxygen administration by nasal cannula (procedure)"
                        }
                      ]
                    }
                  },
                  "timeFromEvent" : [
                    {
                      "eventId" : "covid19",
                      "quantity" : {
                        "value" : 0,
                        "system" : "http://unitsofmeasure.org",
                        "code" : "d"
                      }
                    }
                  ]
                },
                {
                  "linkId" : "noninvasive-ventilation",
                  "exclude" : false,
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "71388002",
                          "display" : "Procedure (procedure)"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "428311008",
                          "display" : "Non-invasive ventilation (regime/therapy)"
                        }
                      ]
                    }
                  },
                  "timeFromEvent" : [
                    {
                      "eventId" : "covid19",
                      "quantity" : {
                        "value" : 0,
                        "system" : "http://unitsofmeasure.org",
                        "code" : "d"
                      }
                    }
                  ]
                },
                {
                  "linkId" : "artificial-respiration",
                  "exclude" : false,
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "71388002",
                          "display" : "Procedure (procedure)"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "40617009",
                          "display" : "Artificial ventilation (regime/therapy)"
                        }
                      ]
                    }
                  },
                  "timeFromEvent" : [
                    {
                      "eventId" : "covid19",
                      "quantity" : {
                        "value" : 0,
                        "system" : "http://unitsofmeasure.org",
                        "code" : "d"
                      }
                    }
                  ]
                }
              ]
            }
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/evidence-variable-non-ventilated",
      "resource" : {
        "resourceType" : "EvidenceVariable",
        "id" : "PopulationCOVID19NonVentilated",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-eligibility-criteria"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"EvidenceVariable_PopulationCOVID19NonVentilated\"> </a><p><b>Generated Narrative: EvidenceVariable</b><a name=\"PopulationCOVID19NonVentilated\"> </a><a name=\"hcPopulationCOVID19NonVentilated\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceEvidenceVariable &quot;PopulationCOVID19NonVentilated&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation-eligibility-criteria.html\">Recommendation Eligibility Criteria</a></p></div><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_NonVentilated</code></p><p><b>identifier</b>: <code>https://www.ceosys.de</code>/NonVentilated</p><p><b>name</b>: Population_COVID19_NonVentilated</p><p><b>status</b>: active</p><p><b>description</b>: Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, not ventilated</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: covid19</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Clinical finding (finding) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#404684003)</span></td><td>Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#840539006)</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>exclude</b>: true</p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: any-of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: oxy-administration-nasal-cannula</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: noninvasive-ventilation</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: artificial-respiration</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote></blockquote></blockquote></div>"
        },
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_NonVentilated",
        "identifier" : [
          {
            "system" : "https://www.ceosys.de",
            "value" : "NonVentilated"
          }
        ],
        "name" : "Population_COVID19_NonVentilated",
        "status" : "active",
        "description" : "Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, not ventilated",
        "characteristic" : [
          {
            "linkId" : "covid19",
            "exclude" : false,
            "definitionByTypeAndValue" : {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://snomed.info/sct",
                    "code" : "404684003",
                    "display" : "Clinical finding (finding)"
                  }
                ]
              },
              "valueCodeableConcept" : {
                "coding" : [
                  {
                    "system" : "http://snomed.info/sct",
                    "code" : "840539006",
                    "display" : "Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"
                  }
                ]
              }
            }
          },
          {
            "exclude" : true,
            "definitionByCombination" : {
              "code" : "any-of",
              "characteristic" : [
                {
                  "linkId" : "oxy-administration-nasal-cannula",
                  "exclude" : false,
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "71388002",
                          "display" : "Procedure (procedure)"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "371907003",
                          "display" : "Oxygen administration by nasal cannula (procedure)"
                        }
                      ]
                    }
                  },
                  "timeFromEvent" : [
                    {
                      "eventId" : "covid19",
                      "quantity" : {
                        "value" : 0,
                        "system" : "http://unitsofmeasure.org",
                        "code" : "d"
                      }
                    }
                  ]
                },
                {
                  "linkId" : "noninvasive-ventilation",
                  "exclude" : false,
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "71388002",
                          "display" : "Procedure (procedure)"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "428311008",
                          "display" : "Non-invasive ventilation (regime/therapy)"
                        }
                      ]
                    }
                  },
                  "timeFromEvent" : [
                    {
                      "eventId" : "covid19",
                      "quantity" : {
                        "value" : 0,
                        "system" : "http://unitsofmeasure.org",
                        "code" : "d"
                      }
                    }
                  ]
                },
                {
                  "linkId" : "artificial-respiration",
                  "exclude" : false,
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "71388002",
                          "display" : "Procedure (procedure)"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "40617009",
                          "display" : "Artificial ventilation (regime/therapy)"
                        }
                      ]
                    }
                  },
                  "timeFromEvent" : [
                    {
                      "eventId" : "covid19",
                      "quantity" : {
                        "value" : 0,
                        "system" : "http://unitsofmeasure.org",
                        "code" : "d"
                      }
                    }
                  ]
                }
              ]
            }
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/rating-outcome-mortality",
      "resource" : {
        "resourceType" : "ArtifactAssessment",
        "id" : "DexamethasoneRatingOutcomeMortality",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/certainty-of-evidence-rating"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ArtifactAssessment_DexamethasoneRatingOutcomeMortality\"> </a><p><b>Generated Narrative: ArtifactAssessment</b><a name=\"DexamethasoneRatingOutcomeMortality\"> </a><a name=\"hcDexamethasoneRatingOutcomeMortality\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceArtifactAssessment &quot;DexamethasoneRatingOutcomeMortality&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-certainty-of-evidence-rating.html\">Certainty of Evidence Rating</a></p></div><p><b>ArtifactAssessment Version</b>: v4.0</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2020-01-03</p><p><b>artifact</b>: See on this page: Evidence/DexamethasoneOutcomeMortality</p><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Overall certainty <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-certainty-type.html\">Evidence Certainty Type</a>#Overall)</span></p><p><b>classifier</b>: Moderate quality <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-certainty-rating.html\">Evidence Certainty Rating</a>#moderate)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Clinical Importance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-code-system.html\">CEOsys Code System</a>#clinical-importance)</span></p><p><b>classifier</b>: Critical <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-clinical-importance.html\">Clinical Importance of Outcome</a>#9)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Risk of bias <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-certainty-type.html\">Evidence Certainty Type</a>#RiskOfBias)</span></p><p><b>classifier</b>: serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-certainty-rating.html\">Evidence Certainty Rating</a>#serious-concern)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Inconsistency <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-certainty-type.html\">Evidence Certainty Type</a>#Inconsistency)</span></p><p><b>classifier</b>: no serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-certainty-rating.html\">Evidence Certainty Rating</a>#no-concern)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Indirectness <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-certainty-type.html\">Evidence Certainty Type</a>#Indirectness)</span></p><p><b>classifier</b>: no serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-certainty-rating.html\">Evidence Certainty Rating</a>#no-concern)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Imprecision <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-certainty-type.html\">Evidence Certainty Type</a>#Imprecision)</span></p><p><b>classifier</b>: no serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-certainty-rating.html\">Evidence Certainty Rating</a>#no-concern)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Publication bias <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-certainty-type.html\">Evidence Certainty Type</a>#PublicationBias)</span></p><p><b>classifier</b>: no serious concern <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-certainty-rating.html\">Evidence Certainty Rating</a>#no-concern)</span></p></blockquote></div>"
        },
        "extension" : [
          {
            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-version",
            "valueString" : "v4.0"
          },
          {
            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-publication-status",
            "valueCode" : "active"
          }
        ],
        "date" : "2020-01-03",
        "artifactReference" : {
          🔗 "reference" : "Evidence/DexamethasoneOutcomeMortality"
        },
        "content" : [
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/certainty-type",
                  "code" : "Overall",
                  "display" : "Overall certainty"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/certainty-rating",
                    "code" : "moderate",
                    "display" : "Moderate quality"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code" : "clinical-importance",
                  "display" : "Clinical Importance"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-clinical-importance",
                    "code" : "9",
                    "display" : "Critical"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/certainty-type",
                  "code" : "RiskOfBias",
                  "display" : "Risk of bias"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/certainty-rating",
                    "code" : "serious-concern",
                    "display" : "serious concern"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/certainty-type",
                  "code" : "Inconsistency",
                  "display" : "Inconsistency"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/certainty-rating",
                    "code" : "no-concern",
                    "display" : "no serious concern"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/certainty-type",
                  "code" : "Indirectness",
                  "display" : "Indirectness"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/certainty-rating",
                    "code" : "no-concern",
                    "display" : "no serious concern"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/certainty-type",
                  "code" : "Imprecision",
                  "display" : "Imprecision"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/certainty-rating",
                    "code" : "no-concern",
                    "display" : "no serious concern"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/certainty-type",
                  "code" : "PublicationBias",
                  "display" : "Publication bias"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/certainty-rating",
                    "code" : "no-concern",
                    "display" : "no serious concern"
                  }
                ]
              }
            ]
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/outcome-mortality",
      "resource" : {
        "resourceType" : "Evidence",
        "id" : "DexamethasoneOutcomeMortality",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-evidence-synthesis"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Evidence_DexamethasoneOutcomeMortality\"> </a><p><b>Generated Narrative: Evidence</b><a name=\"DexamethasoneOutcomeMortality\"> </a><a name=\"hcDexamethasoneOutcomeMortality\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceEvidence &quot;DexamethasoneOutcomeMortality&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-outcome-evidence-synthesis.html\">Outcome Evidence Synthesis</a></p></div><p><b>name</b>: ExampleOutcomeEvidence</p><p><b>status</b>: active</p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>citation</td><td>See on this page: Citation/SystemicCorticosteroidsForTheTreatmentOfCOVID19</td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: population <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-variable-role.html\">EvidenceVariableRole</a>#population)</span></p><p><b>observed</b>: <a href=\"Group-StudyCohortCorticosteroidsCOVID19.html\">Group/StudyCohortCorticosteroidsCOVID19</a> &quot;StudyCohortCriteriaSystemicCorticosteroidsCOVID19&quot;</p><p><b>intended</b>: See on this page: EvidenceVariable/StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: measured variable <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-variable-role.html\">EvidenceVariableRole</a>#measuredVariable)</span></p><p><b>observed</b>: See on this page: EvidenceVariable/OutcomeAllCauseMortality</p></blockquote><p><b>synthesisType</b>: not applicable <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-synthesis-type.html\">SynthesisType</a>#NotApplicable)</span></p><blockquote><p><b>statistic</b></p><p><b>description</b>: Relative effect of intervention vs. comparator</p><p><b>statisticType</b>: Relative Risk <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-statistic-type.html\">StatisticStatisticType</a>#C93152)</span></p><p><b>quantity</b>: 0.89</p><h3>SampleSizes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>NumberOfStudies</b></td><td><b>NumberOfParticipants</b></td></tr><tr><td style=\"display: none\">*</td><td>9</td><td>7930</td></tr></table><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>Confidence interval <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-attribute-estimate-type.html\">StatisticAttribute Estimate Type</a>#C53324)</span></td><td>0.95</td><td>0.8-1</td></tr></table></blockquote><blockquote><p><b>statistic</b></p><p><b>description</b>: Baseline risk/result in the comparison group</p><p><b>statisticType</b>: Incidence <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-statistic-type.html\">StatisticStatisticType</a>#C16726)</span></p><p><b>quantity</b>: 245 1/1000<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code 1/1000 = '1/1000')</span></p></blockquote></div>"
        },
        "name" : "ExampleOutcomeEvidence",
        "status" : "active",
        "relatedArtifact" : [
          {
            "type" : "citation",
            "resourceReference" : {
              🔗 "reference" : "Citation/SystemicCorticosteroidsForTheTreatmentOfCOVID19"
            }
          }
        ],
        "variableDefinition" : [
          {
            "variableRole" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/variable-role",
                  "code" : "population"
                }
              ]
            },
            "observed" : {
              🔗 "reference" : "Group/StudyCohortCorticosteroidsCOVID19"
            },
            "intended" : {
              🔗 "reference" : "EvidenceVariable/StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"
            }
          },
          {
            "variableRole" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/variable-role",
                  "code" : "measuredVariable"
                }
              ]
            },
            "observed" : {
              🔗 "reference" : "EvidenceVariable/OutcomeAllCauseMortality"
            }
          }
        ],
        "synthesisType" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/synthesis-type",
              "code" : "NotApplicable"
            }
          ]
        },
        "statistic" : [
          {
            "description" : "Relative effect of intervention vs. comparator",
            "statisticType" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/statistic-type",
                  "code" : "C93152",
                  "display" : "Relative Risk"
                }
              ]
            },
            "quantity" : {
              "value" : 0.89
            },
            "sampleSize" : {
              "numberOfStudies" : 9,
              "numberOfParticipants" : 7930
            },
            "attributeEstimate" : [
              {
                "type" : {
                  "coding" : [
                    {
                      "system" : "http://terminology.hl7.org/CodeSystem/attribute-estimate-type",
                      "code" : "C53324",
                      "display" : "Confidence interval"
                    }
                  ]
                },
                "level" : 0.95,
                "range" : {
                  "low" : {
                    "value" : 0.8
                  },
                  "high" : {
                    "value" : 1
                  }
                }
              }
            ]
          },
          {
            "description" : "Baseline risk/result in the comparison group",
            "statisticType" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/statistic-type",
                  "code" : "C16726",
                  "display" : "Incidence"
                }
              ]
            },
            "quantity" : {
              "value" : 245,
              "system" : "http://unitsofmeasure.org",
              "code" : "1/1000"
            }
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/study-eligibility-criteria",
      "resource" : {
        "resourceType" : "EvidenceVariable",
        "id" : "StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-eligibility-criteria"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"EvidenceVariable_StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19\"> </a><p><b>Generated Narrative: EvidenceVariable</b><a name=\"StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19\"> </a><a name=\"hcStudyEligibilityCriteriaSystemicCorticosteroidsCOVID19\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceEvidenceVariable &quot;StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-study-eligibility-criteria.html\">Study Eligibility Criteria</a></p></div><p><b>name</b>: StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</p><p><b>status</b>: active</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Clinical finding (finding) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#404684003)</span></td><td>Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#840539006)</span></td></tr></table></blockquote></div>"
        },
        "name" : "StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19",
        "status" : "active",
        "characteristic" : [
          {
            "definitionByTypeAndValue" : {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://snomed.info/sct",
                    "code" : "404684003",
                    "display" : "Clinical finding (finding)"
                  }
                ]
              },
              "valueCodeableConcept" : {
                "coding" : [
                  {
                    "system" : "http://snomed.info/sct",
                    "code" : "840539006",
                    "display" : "Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"
                  }
                ]
              }
            }
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/outcome-all-cause-mortality",
      "resource" : {
        "resourceType" : "EvidenceVariable",
        "id" : "OutcomeAllCauseMortality",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-definition"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"EvidenceVariable_OutcomeAllCauseMortality\"> </a><p><b>Generated Narrative: EvidenceVariable</b><a name=\"OutcomeAllCauseMortality\"> </a><a name=\"hcOutcomeAllCauseMortality\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceEvidenceVariable &quot;OutcomeAllCauseMortality&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-outcome-definition.html\">Outcome Definition</a></p></div><p><b>name</b>: AllCauseMortality</p><p><b>status</b>: active</p><h3>Characteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Exclude</b></td><td><b>DefinitionCodeableConcept</b></td></tr><tr><td style=\"display: none\">*</td><td>false</td><td>Mortality rate (observable entity) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOWMED CT</a>#409651001)</span></td></tr></table><p><b>handling</b>: dichotomous</p></div>"
        },
        "name" : "AllCauseMortality",
        "status" : "active",
        "characteristic" : [
          {
            "exclude" : false,
            "definitionCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://snomed.info/sct",
                  "code" : "409651001",
                  "display" : "Mortality rate (observable entity)"
                }
              ]
            }
          }
        ],
        "handling" : "dichotomous"
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-justification",
      "resource" : {
        "resourceType" : "ArtifactAssessment",
        "id" : "DexamethasoneRecommendationJustification",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-justification"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ArtifactAssessment_DexamethasoneRecommendationJustification\"> </a><p><b>Generated Narrative: ArtifactAssessment</b><a name=\"DexamethasoneRecommendationJustification\"> </a><a name=\"hcDexamethasoneRecommendationJustification\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceArtifactAssessment &quot;DexamethasoneRecommendationJustification&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation-justification.html\">Recommendation Justification</a></p></div><p><b>ArtifactAssessment Version</b>: v4.0</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2020-01-03</p><p><b>artifact</b>: See on this page: PlanDefinition/COVID19VentilatedPatientsDexamethasoneApplicationPlan</p><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Strength of recommendation <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-code-system.html\">CEOsys Code System</a>#strength)</span></p><p><b>classifier</b>: Strong for an intervention <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-cs-recommendation-strength.html\">Recommendation Strength</a>#strong-for)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Consensus <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-code-system.html\">CEOsys Code System</a>#consensus)</span></p><p><b>classifier</b>: Strong <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-recommendation-strength.html\">StrengthOfRecommendationRating</a>#strong)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Preference and values <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-evidence-to-decision-certainty-type.html\">Evidence To Decision Certainty type</a>#preference-and-values)</span></p><p><b>classifier</b>: Factor not considered <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-evidence-to-decision-certainty-rating.html\">Evidence To Decision Certainty Rating</a>#factor-not-considered)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Resources <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-evidence-to-decision-certainty-type.html\">Evidence To Decision Certainty type</a>#resources)</span></p><p><b>classifier</b>: No important issues <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-evidence-to-decision-certainty-rating.html\">Evidence To Decision Certainty Rating</a>#no-important-issues)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Acceptability <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-evidence-to-decision-certainty-type.html\">Evidence To Decision Certainty type</a>#acceptability)</span></p><p><b>classifier</b>: Factor not considered <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-evidence-to-decision-certainty-rating.html\">Evidence To Decision Certainty Rating</a>#factor-not-considered)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Feasibility <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-evidence-to-decision-certainty-type.html\">Evidence To Decision Certainty type</a>#feasibility)</span></p><p><b>classifier</b>: Factor not considered <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-evidence-to-decision-certainty-rating.html\">Evidence To Decision Certainty Rating</a>#factor-not-considered)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: container</p><p><b>type</b>: Certainty of evidence rating <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-code-system.html\">CEOsys Code System</a>#certainty-of-evidence-rating)</span></p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>justification</td><td>Certainty of evidence rating <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ceosys-code-system.html\">CEOsys Code System</a>#certainty-of-evidence-rating)</span></td><td>See on this page: ArtifactAssessment/DexamethasoneRatingOutcomeMortality</td></tr></table></blockquote></div>"
        },
        "extension" : [
          {
            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-version",
            "valueString" : "v4.0"
          },
          {
            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-publication-status",
            "valueCode" : "active"
          }
        ],
        "date" : "2020-01-03",
        "artifactReference" : {
          🔗 "reference" : "PlanDefinition/COVID19VentilatedPatientsDexamethasoneApplicationPlan"
        },
        "content" : [
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code" : "strength",
                  "display" : "Strength of recommendation"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-cs-recommendation-strength",
                    "code" : "strong-for"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code" : "consensus",
                  "display" : "Consensus"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/recommendation-strength",
                    "code" : "strong",
                    "display" : "Strong"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type",
                  "code" : "preference-and-values",
                  "display" : "Preference and values"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating",
                    "code" : "factor-not-considered",
                    "display" : "Factor not considered"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type",
                  "code" : "resources",
                  "display" : "Resources"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating",
                    "code" : "no-important-issues",
                    "display" : "No important issues"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type",
                  "code" : "acceptability",
                  "display" : "Acceptability"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating",
                    "code" : "factor-not-considered",
                    "display" : "Factor not considered"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-type",
                  "code" : "feasibility",
                  "display" : "Feasibility"
                }
              ]
            },
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-evidence-to-decision-certainty-rating",
                    "code" : "factor-not-considered",
                    "display" : "Factor not considered"
                  }
                ]
              }
            ]
          },
          {
            "informationType" : "container",
            "type" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code" : "certainty-of-evidence-rating",
                  "display" : "Certainty of evidence rating"
                }
              ]
            },
            "relatedArtifact" : [
              {
                "type" : "justification",
                "classifier" : [
                  {
                    "coding" : [
                      {
                        "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                        "code" : "certainty-of-evidence-rating",
                        "display" : "Certainty of evidence rating"
                      }
                    ]
                  }
                ],
                "resourceReference" : {
                  🔗 "reference" : "ArtifactAssessment/DexamethasoneRatingOutcomeMortality"
                }
              }
            ]
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/study-citation",
      "resource" : {
        "resourceType" : "Citation",
        "id" : "SystemicCorticosteroidsForTheTreatmentOfCOVID19",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-citation"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Citation_SystemicCorticosteroidsForTheTreatmentOfCOVID19\"> </a><p><b>Generated Narrative: Citation</b><a name=\"SystemicCorticosteroidsForTheTreatmentOfCOVID19\"> </a><a name=\"hcSystemicCorticosteroidsForTheTreatmentOfCOVID19\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceCitation &quot;SystemicCorticosteroidsForTheTreatmentOfCOVID19&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-study-citation.html\">Study Citation</a></p></div><p><b>name</b>: SystemicCorticosteroidsForTheTreatmentOfCOVID19</p><p><b>status</b>: active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/34396514, <code>https://doi.org</code>/10.1002/14651858.CD014963, <code>https://www.ncbi.nlm.nih.gov/pmc/</code>/PMC8406706</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>Systemic corticosteroids for the treatment of COVID-19</td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>Publication Type <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#publication-type)</span></td><td>Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></td></tr></table></blockquote></div>"
        },
        "name" : "SystemicCorticosteroidsForTheTreatmentOfCOVID19",
        "status" : "active",
        "citedArtifact" : {
          "identifier" : [
            {
              "system" : "https://pubmed.ncbi.nlm.nih.gov",
              "value" : "34396514"
            },
            {
              "system" : "https://doi.org",
              "value" : "10.1002/14651858.CD014963"
            },
            {
              "system" : "https://www.ncbi.nlm.nih.gov/pmc/",
              "value" : "PMC8406706"
            }
          ],
          "title" : [
            {
              "text" : "Systemic corticosteroids for the treatment of COVID-19"
            }
          ],
          "classification" : [
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                    "code" : "publication-type",
                    "display" : "Publication Type"
                  }
                ]
              },
              "classifier" : [
                {
                  "coding" : [
                    {
                      "system" : "http://hl7.org/fhir/citation-artifact-classifier",
                      "code" : "D016428",
                      "display" : "Journal Article"
                    }
                  ]
                }
              ]
            }
          ]
        }
      }
    }
  ]
}