Clinical Practice Guidelines (CPG) on EBMonFHIR
1.0.2 - qa-preview

This page is part of the CPG-on-EBMonFHIR Implementation Guide (1.0.2).

: COVID19 Intensive Care Treatment Guideline - JSON Representation

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{
  "resourceType" : "Bundle",
  "id" : "COVID19IntensiveCareTreatmentGuidelineBundle",
  "meta" : {
    "profile" : [
      🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-bundle"
    ]
  },
  "type" : "collection",
  "entry" : [
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/guideline",
      "resource" : {
        "resourceType" : "Composition",
        "id" : "COVID19IntensiveCareTreatmentGuideline",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Composition_COVID19IntensiveCareTreatmentGuideline\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Composition COVID19IntensiveCareTreatmentGuideline</b></p><a name=\"COVID19IntensiveCareTreatmentGuideline\"> </a><a name=\"hcCOVID19IntensiveCareTreatmentGuideline\"> </a><a name=\"COVID19IntensiveCareTreatmentGuideline-en-US\"> </a><p><b>identifier</b>: Resource identifier/113-001</p><p><b>version</b>: 7.0</p><p><b>status</b>: Final</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}, {https://data.cochrane.org/concepts/ e07eN1w1Rwswg4}\">Guidelines</span></p><p><b>category</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification S3}\">Evidence- and consensus-based guideline</span></p><p><b>date</b>: 2022-03-01</p><p><b>author</b>: <a href=\"Organization-AWMFOrganization.html\">Organization Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) e.V.</a></p><p><b>title</b>: Empfehlungen zur stationären Therapie von Patienten mit COVID-19 - Living Guideline</p><h3>RelatesTos</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><a href=\"Citation-COVID19IntensiveCareTreatmentGuidelineCitation.html\">Citation COVID19_Intensive_Care_Treatment_Guideline</a></td></tr></table></div>"
        },
        "identifier" : [
          {
            "type" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                  "code" : "RI",
                  "display" : "Resource identifier"
                }
              ]
            },
            "system" : "https://www.awmf.org/",
            "value" : "113-001"
          }
        ],
        "version" : "7.0",
        "status" : "final",
        "type" : {
          "coding" : [
            {
              "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
              "code" : "clinical-practice-guideline"
            },
            {
              "system" : "https://data.cochrane.org/concepts/",
              "code" : "e07eN1w1Rwswg4",
              "display" : "Guidelines"
            }
          ]
        },
        "category" : [
          {
            "coding" : [
              {
                "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification",
                "code" : "S3",
                "display" : "Evidence- and consensus-based guideline"
              }
            ]
          }
        ],
        "date" : "2022-03-01",
        "author" : [
          {
            🔗 "reference" : "Organization/AWMFOrganization"
          }
        ],
        "title" : "Empfehlungen zur stationären Therapie von Patienten mit COVID-19 - Living Guideline",
        "relatesTo" : [
          {
            "type" : "citation",
            "resourceReference" : {
              🔗 "reference" : "Citation/COVID19IntensiveCareTreatmentGuidelineCitation"
            }
          }
        ],
        "section" : [
          {
            "title" : "Stationäre Therapie von COVID-19 Patienten",
            "code" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code" : "guideline-recommendation",
                  "display" : "Clinical practice guideline recommendation"
                }
              ]
            },
            "focus" : {
              🔗 "reference" : "PlanDefinition/COVID19VentilatedPatientsDexamethasoneApplicationPlan"
            },
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><strong>Systemische Steroide:</strong> Bei Patienten mit COVID-19- und Sauerstoff-Bedarf (Niedrigfluss-Sauerstoff-Insufflation, High-Flow Nasal Cannula, Nichtinvasive Beatmung/CPAP, invasive Beatmung) soll eine Therapie mit systemischen Kortikosteroiden erfolgen. Die Therapie sollte mit 6 mg Dexamethason p.o. oder i.v. über zehn Tage erfolgen.</div>"
            }
          },
          {
            "title" : "Stationäre Therapie von COVID-19 Patienten",
            "code" : {
              "coding" : [
                {
                  "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code" : "guideline-recommendation",
                  "display" : "Clinical practice guideline recommendation"
                }
              ]
            },
            "focus" : {
              🔗 "reference" : "PlanDefinition/COVID19NonVentilatedPatientsDexamethasoneApplicationPlan"
            },
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><strong>Systemische Steroide:</strong> Bei Patienten mit moderater Erkrankung (hospitalisiert ohne Notwendigkeit von Niedrigfluss-Sauerstoff-Insufflation) soll keine Therapie mit systemischen Kortikosteroiden erfolgen.</div>"
            }
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/guideline-citation",
      "resource" : {
        "resourceType" : "Citation",
        "id" : "COVID19IntensiveCareTreatmentGuidelineCitation",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-citation"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Citation_COVID19IntensiveCareTreatmentGuidelineCitation\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Citation COVID19IntensiveCareTreatmentGuidelineCitation</b></p><a name=\"COVID19IntensiveCareTreatmentGuidelineCitation\"> </a><a name=\"hcCOVID19IntensiveCareTreatmentGuidelineCitation\"> </a><a name=\"COVID19IntensiveCareTreatmentGuidelineCitation-en-US\"> </a><p><b>name</b>: COVID19_Intensive_Care_Treatment_Guideline</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://www.awmf.org/</code>/113-001</p><h3>Versions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Value</b></td></tr><tr><td style=\"display: none\">*</td><td>7.0</td></tr></table><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-status-type active}\">Active</span></p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p>S3-Leitlinie Stationäre Therapie von COVID-19 Patienten</p>\n</div></td></tr></table><h3>WebLocations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://www.awmf.org/leitlinien/detail/ll/113-001.html\">https://www.awmf.org/leitlinien/detail/ll/113-001.html</a></td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}\">Publication Type</span></td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}\">Clinical practice guideline</span></td></tr></table></blockquote></div>"
        },
        "name" : "COVID19_Intensive_Care_Treatment_Guideline",
        "status" : "active",
        "citedArtifact" : {
          "identifier" : [
            {
              "system" : "https://www.awmf.org/",
              "value" : "113-001"
            }
          ],
          "version" : {
            "value" : "7.0"
          },
          "currentState" : [
            {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/cited-artifact-status-type",
                  "code" : "active",
                  "display" : "Active"
                }
              ]
            }
          ],
          "title" : [
            {
              "text" : "S3-Leitlinie Stationäre Therapie von COVID-19 Patienten"
            }
          ],
          "webLocation" : [
            {
              "url" : "https://www.awmf.org/leitlinien/detail/ll/113-001.html"
            }
          ],
          "classification" : [
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/cited-artifact-classification-type",
                    "code" : "publication-type",
                    "display" : "Publication Type"
                  }
                ]
              },
              "classifier" : [
                {
                  "coding" : [
                    {
                      "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                      "code" : "clinical-practice-guideline",
                      "display" : "Clinical practice guideline"
                    }
                  ]
                }
              ]
            }
          ]
        }
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation",
      "resource" : {
        "resourceType" : "PlanDefinition",
        "id" : "COVID19DexamethasoneApplication",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_COVID19DexamethasoneApplication\"> </a><p class=\"res-header-id\"><b>Generated Narrative: PlanDefinition COVID19DexamethasoneApplication</b></p><a name=\"COVID19DexamethasoneApplication\"> </a><a name=\"hcCOVID19DexamethasoneApplication\"> </a><a name=\"COVID19DexamethasoneApplication-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method one-or-more}\">One or More</span></li></ul></blockquote><p><b>url</b>: <a href=\"PlanDefinition-COVID19DexamethasoneApplication.html\">PlanDefinition Dexamethasone Application</a></p><p><b>version</b>: 4.0</p><p><b>name</b>: Dexamethasone_Application</p><p><b>title</b>: Dexamethasone Application</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type workflow-definition}\">Workflow Definition</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href=\"EvidenceVariable-PopulationCOVID19Ventilated.html\">Population_COVID19_Ventilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone for ventilated patients only</p>\n</div><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Justification</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system recommendation-rating}\">Recommendation rating</span></td><td><a href=\"ArtifactAssessment-DexamethasoneRecommendationJustification.html\">ArtifactAssessment: extension = v4.0,active; date = 2020-01-03; artifact[x] = -&gt;PlanDefinition Dexamethasone Application in ventilated COVID-19 patients</a></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system guideline-recommendation}\">Clinical practice guideline recommendation</span></td><td><a href=\"Citation-DexamethasoneRecommendationCitation.html\">Citation DexamethasoneRecommendationCitation</a></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}\">Clinical practice guideline</span></td><td><a href=\"Citation-COVID19IntensiveCareTreatmentGuidelineCitation.html\">Citation COVID19_Intensive_Care_Treatment_Guideline</a></td></tr></table><blockquote><p><b>action</b></p><p><b>title</b>: Dexamethasone Application</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients</p>\n</div><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}\">Guideline-based Care</span></p><p><b>definition</b>: <a href=\"PlanDefinition-COVID19VentilatedPatientsDexamethasoneApplicationPlan.html\">Dexamethasone Application in ventilated COVID-19 patients</a></p></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: No Dexamethasone Application</p><p><b>description</b>: </p><div><p>No Dexamethasone Application for non-ventilated COVID-19 patients</p>\n</div><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}\">Guideline-based Care</span></p><p><b>definition</b>: <a href=\"PlanDefinition-COVID19NonVentilatedPatientsDexamethasoneApplicationPlan.html\">No Dexamethasone Application for non-ventilated COVID-19 patients</a></p></blockquote></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          },
          {
            "extension" : [
              {
                "url" : "method",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method",
                      "code" : "one-or-more"
                    }
                  ]
                }
              }
            ],
            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation",
        "version" : "4.0",
        "name" : "Dexamethasone_Application",
        "title" : "Dexamethasone Application",
        "type" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
              "code" : "workflow-definition"
            }
          ]
        },
        "status" : "active",
        "experimental" : true,
        "subjectCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated",
        "date" : "2021-12-12",
        "publisher" : "CPGonEBMonFHIR",
        "description" : "Application of Dexamethasone for ventilated patients only",
        "relatedArtifact" : [
          {
            "type" : "justification",
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                    "code" : "recommendation-rating",
                    "display" : "Recommendation rating"
                  }
                ]
              }
            ],
            "resourceReference" : {
              🔗 "reference" : "ArtifactAssessment/DexamethasoneRecommendationJustification"
            }
          },
          {
            "type" : "citation",
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                    "code" : "guideline-recommendation",
                    "display" : "Clinical practice guideline recommendation"
                  }
                ]
              }
            ],
            "resourceReference" : {
              🔗 "reference" : "Citation/DexamethasoneRecommendationCitation"
            }
          },
          {
            "type" : "citation",
            "classifier" : [
              {
                "coding" : [
                  {
                    "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                    "code" : "clinical-practice-guideline",
                    "display" : "Clinical practice guideline"
                  }
                ]
              }
            ],
            "resourceReference" : {
              🔗 "reference" : "Citation/COVID19IntensiveCareTreatmentGuidelineCitation"
            }
          }
        ],
        "action" : [
          {
            "title" : "Dexamethasone Application",
            "description" : "Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients",
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process",
                  "code" : "guideline-based-care"
                }
              ]
            },
            "definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-ventilated-patients-dexamethasone-application-plan"
          },
          {
            "title" : "No Dexamethasone Application",
            "description" : "No Dexamethasone Application for non-ventilated COVID-19 patients",
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process",
                  "code" : "guideline-based-care"
                }
              ]
            },
            "definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-non-ventilated-patients-no-dexamethasone-application-plan"
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-plan-ventilated-patients",
      "resource" : {
        "resourceType" : "PlanDefinition",
        "id" : "COVID19VentilatedPatientsDexamethasoneApplicationPlan",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_COVID19VentilatedPatientsDexamethasoneApplicationPlan\"> </a><p class=\"res-header-id\"><b>Generated Narrative: PlanDefinition COVID19VentilatedPatientsDexamethasoneApplicationPlan</b></p><a name=\"COVID19VentilatedPatientsDexamethasoneApplicationPlan\"> </a><a name=\"hcCOVID19VentilatedPatientsDexamethasoneApplicationPlan\"> </a><a name=\"COVID19VentilatedPatientsDexamethasoneApplicationPlan-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href=\"PlanDefinition-COVID19DexamethasoneApplication.html\">Dexamethasone Application</a></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method exactly}\">Exactly</span></li><li>threshold: 1</li></ul></blockquote><p><b>url</b>: <a href=\"PlanDefinition-COVID19VentilatedPatientsDexamethasoneApplicationPlan.html\">PlanDefinition Dexamethasone Application in ventilated COVID-19 patients</a></p><p><b>version</b>: 4.0</p><p><b>name</b>: Dexamethasone_Application</p><p><b>title</b>: Dexamethasone Application in ventilated COVID-19 patients</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type eca-rule}\">ECA Rule</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href=\"EvidenceVariable-PopulationCOVID19Ventilated.html\">Population_COVID19_Ventilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients</p>\n</div><blockquote><p><b>action</b></p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></p><p><b>definition</b>: <a href=\"Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html\">DexamethasoneApplicationActionOral</a></p></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></p><p><b>definition</b>: <a href=\"Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html\">DexamethasoneApplicationActionIntravenous</a></p></blockquote></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-partOf",
            "valueCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation"
          },
          {
            "extension" : [
              {
                "url" : "method",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method",
                      "code" : "exactly"
                    }
                  ]
                }
              },
              {
                "url" : "threshold",
                "valuePositiveInt" : 1
              }
            ],
            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-ventilated-patients-dexamethasone-application-plan",
        "version" : "4.0",
        "name" : "Dexamethasone_Application",
        "title" : "Dexamethasone Application in ventilated COVID-19 patients",
        "type" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
              "code" : "eca-rule"
            }
          ]
        },
        "status" : "active",
        "experimental" : true,
        "subjectCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated",
        "date" : "2021-12-12",
        "publisher" : "CPGonEBMonFHIR",
        "description" : "Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients",
        "action" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://snomed.info/sct",
                  "code" : "432102000",
                  "display" : "Administration of substance (procedure)"
                }
              ]
            },
            "definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral"
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://snomed.info/sct",
                  "code" : "432102000",
                  "display" : "Administration of substance (procedure)"
                }
              ]
            },
            "definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous"
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-plan-non-ventilated-patients",
      "resource" : {
        "resourceType" : "PlanDefinition",
        "id" : "COVID19NonVentilatedPatientsDexamethasoneApplicationPlan",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_COVID19NonVentilatedPatientsDexamethasoneApplicationPlan\"> </a><p class=\"res-header-id\"><b>Generated Narrative: PlanDefinition COVID19NonVentilatedPatientsDexamethasoneApplicationPlan</b></p><a name=\"COVID19NonVentilatedPatientsDexamethasoneApplicationPlan\"> </a><a name=\"hcCOVID19NonVentilatedPatientsDexamethasoneApplicationPlan\"> </a><a name=\"COVID19NonVentilatedPatientsDexamethasoneApplicationPlan-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href=\"PlanDefinition-COVID19DexamethasoneApplication.html\">Dexamethasone Application</a></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method exactly}\">Exactly</span></li><li>threshold: 1</li></ul></blockquote><p><b>url</b>: <a href=\"PlanDefinition-COVID19NonVentilatedPatientsDexamethasoneApplicationPlan.html\">PlanDefinition No Dexamethasone Application for non-ventilated COVID-19 patients</a></p><p><b>version</b>: 4.0</p><p><b>name</b>: No_Dexamethasone_Application</p><p><b>title</b>: No Dexamethasone Application for non-ventilated COVID-19 patients</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type eca-rule}\">ECA Rule</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href=\"EvidenceVariable-PopulationCOVID19NonVentilated.html\">Population_COVID19_NonVentilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>No Dexamethasone Application for non-ventilated COVID19 patients</p>\n</div><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></td><td><a href=\"Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html\">NoDexamethasoneApplicationActivity</a></td></tr></table></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-partOf",
            "valueCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation"
          },
          {
            "extension" : [
              {
                "url" : "method",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method",
                      "code" : "exactly"
                    }
                  ]
                }
              },
              {
                "url" : "threshold",
                "valuePositiveInt" : 1
              }
            ],
            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-non-ventilated-patients-no-dexamethasone-application-plan",
        "version" : "4.0",
        "name" : "No_Dexamethasone_Application",
        "title" : "No Dexamethasone Application for non-ventilated COVID-19 patients",
        "type" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
              "code" : "eca-rule"
            }
          ]
        },
        "status" : "active",
        "experimental" : true,
        "subjectCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_NonVentilated",
        "date" : "2021-12-12",
        "publisher" : "CPGonEBMonFHIR",
        "description" : "No Dexamethasone Application for non-ventilated COVID19 patients",
        "action" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://snomed.info/sct",
                  "code" : "432102000",
                  "display" : "Administration of substance (procedure)"
                }
              ]
            },
            "definitionCanonical" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application"
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-oral",
      "resource" : {
        "resourceType" : "ActivityDefinition",
        "id" : "DexamethasoneApplicationActionOral",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ActivityDefinition_DexamethasoneApplicationActionOral\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ActivityDefinition DexamethasoneApplicationActionOral</b></p><a name=\"DexamethasoneApplicationActionOral\"> </a><a name=\"hcDexamethasoneApplicationActionOral\"> </a><a name=\"DexamethasoneApplicationActionOral-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href=\"ActivityDefinition-DexamethasoneApplicationActionOral.html\">ActivityDefinition DexamethasoneApplicationActionOral</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: DexamethasoneApplicationActionOral</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title=\"Codes:{http://hl7.org/fhir/fhir-types Patient}\">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days (oral route)</p>\n</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></p><p><b>product</b>: <span title=\"Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}\">Dexamethasone (substance)</span></p><blockquote><p><b>dosage</b></p><p><b>timing</b>: Count 10  times, Duration 10days , Once per 1 days</p><p><b>route</b>: <span title=\"Codes:{http://snomed.info/sct 26643006}\">Oral route</span></p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td><td><b>Rate[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>6 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg = 'mg')</span></td><td>1 /d<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code/d = '/d')</span></td></tr></table></blockquote></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral",
        "version" : "1.0",
        "name" : "DexamethasoneApplicationActionOral",
        "status" : "active",
        "experimental" : true,
        "subjectCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/fhir-types",
              "code" : "Patient"
            }
          ]
        },
        "publisher" : "CPGonEBMonFHIR",
        "description" : "Application of Dexamethasone: 6 mg once per day for 10 days (oral route)",
        "kind" : "MedicationRequest",
        "code" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "432102000",
              "display" : "Administration of substance (procedure)"
            }
          ]
        },
        "productCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "372584003",
              "display" : "Dexamethasone (substance)"
            },
            {
              "system" : "http://fhir.de/CodeSystem/bfarm/atc",
              "code" : "C05AA09",
              "display" : "Dexamethason"
            }
          ]
        },
        "dosage" : [
          {
            "timing" : {
              "repeat" : {
                "count" : 10,
                "duration" : 10,
                "durationUnit" : "d",
                "frequency" : 1,
                "period" : 1,
                "periodUnit" : "d"
              }
            },
            "route" : {
              "coding" : [
                {
                  "system" : "http://snomed.info/sct",
                  "code" : "26643006",
                  "display" : "Oral route"
                }
              ]
            },
            "doseAndRate" : [
              {
                "doseQuantity" : {
                  "value" : 6,
                  "unit" : "mg",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "mg"
                },
                "rateQuantity" : {
                  "value" : 1,
                  "unit" : "/d",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "/d"
                }
              }
            ]
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-intravenous",
      "resource" : {
        "resourceType" : "ActivityDefinition",
        "id" : "DexamethasoneApplicationActionIntravenous",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ActivityDefinition_DexamethasoneApplicationActionIntravenous\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ActivityDefinition DexamethasoneApplicationActionIntravenous</b></p><a name=\"DexamethasoneApplicationActionIntravenous\"> </a><a name=\"hcDexamethasoneApplicationActionIntravenous\"> </a><a name=\"DexamethasoneApplicationActionIntravenous-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href=\"ActivityDefinition-DexamethasoneApplicationActionIntravenous.html\">ActivityDefinition DexamethasoneApplicationActionIntravenous</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: DexamethasoneApplicationActionIntravenous</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title=\"Codes:{http://hl7.org/fhir/fhir-types Patient}\">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Application of Dexamethasone: 6 mg once per day for 10 days (intravenous route)</p>\n</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></p><p><b>product</b>: <span title=\"Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}\">Dexamethasone (substance)</span></p><blockquote><p><b>dosage</b></p><p><b>timing</b>: Count 10  times, Duration 10days , Once per 1 days</p><p><b>route</b>: <span title=\"Codes:{http://snomed.info/sct 47625008}\">Intravenous route</span></p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td><td><b>Rate[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>6 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg = 'mg')</span></td><td>1 /d<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code/d = '/d')</span></td></tr></table></blockquote></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous",
        "version" : "1.0",
        "name" : "DexamethasoneApplicationActionIntravenous",
        "status" : "active",
        "experimental" : true,
        "subjectCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/fhir-types",
              "code" : "Patient"
            }
          ]
        },
        "publisher" : "CPGonEBMonFHIR",
        "description" : "Application of Dexamethasone: 6 mg once per day for 10 days (intravenous route)",
        "kind" : "MedicationRequest",
        "code" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "432102000",
              "display" : "Administration of substance (procedure)"
            }
          ]
        },
        "productCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "372584003",
              "display" : "Dexamethasone (substance)"
            },
            {
              "system" : "http://fhir.de/CodeSystem/bfarm/atc",
              "code" : "C05AA09",
              "display" : "Dexamethason"
            }
          ]
        },
        "dosage" : [
          {
            "timing" : {
              "repeat" : {
                "count" : 10,
                "duration" : 10,
                "durationUnit" : "d",
                "frequency" : 1,
                "period" : 1,
                "periodUnit" : "d"
              }
            },
            "route" : {
              "coding" : [
                {
                  "system" : "http://snomed.info/sct",
                  "code" : "47625008",
                  "display" : "Intravenous route"
                }
              ]
            },
            "doseAndRate" : [
              {
                "doseQuantity" : {
                  "value" : 6,
                  "unit" : "mg",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "mg"
                },
                "rateQuantity" : {
                  "value" : 1,
                  "unit" : "/d",
                  "system" : "http://unitsofmeasure.org",
                  "code" : "/d"
                }
              }
            ]
          }
        ]
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-no-application",
      "resource" : {
        "resourceType" : "ActivityDefinition",
        "id" : "NoDexamethasoneApplication",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ActivityDefinition_NoDexamethasoneApplication\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ActivityDefinition NoDexamethasoneApplication</b></p><a name=\"NoDexamethasoneApplication\"> </a><a name=\"hcNoDexamethasoneApplication\"> </a><a name=\"NoDexamethasoneApplication-en-US\"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href=\"ActivityDefinition-NoDexamethasoneApplication.html\">ActivityDefinition NoDexamethasoneApplicationActivity</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: NoDexamethasoneApplicationActivity</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title=\"Codes:{http://hl7.org/fhir/fhir-types Patient}\">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>No Application of Dexamethasone</p>\n</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 432102000}\">Administration of substance (procedure)</span></p><p><b>doNotPerform</b>: true</p><p><b>product</b>: <span title=\"Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}\">Dexamethasone (substance)</span></p></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode" : "computable"
          },
          {
            "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode" : "structured"
          }
        ],
        "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application",
        "version" : "1.0",
        "name" : "NoDexamethasoneApplicationActivity",
        "status" : "active",
        "experimental" : true,
        "subjectCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/fhir-types",
              "code" : "Patient"
            }
          ]
        },
        "publisher" : "CPGonEBMonFHIR",
        "description" : "No Application of Dexamethasone",
        "kind" : "MedicationRequest",
        "code" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "432102000",
              "display" : "Administration of substance (procedure)"
            }
          ]
        },
        "doNotPerform" : true,
        "productCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "372584003",
              "display" : "Dexamethasone (substance)"
            },
            {
              "system" : "http://fhir.de/CodeSystem/bfarm/atc",
              "code" : "C05AA09",
              "display" : "Dexamethason"
            }
          ]
        }
      }
    },
    {
      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-citation",
      "resource" : {
        "resourceType" : "Citation",
        "id" : "DexamethasoneRecommendationCitation",
        "meta" : {
          "profile" : [
            🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-citation"
          ]
        },
        "text" : {
          "status" : "generated",
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          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ArtifactAssessment_DexamethasoneRatingOutcomeMortality\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment DexamethasoneRatingOutcomeMortality</b></p><a name=\"DexamethasoneRatingOutcomeMortality\"> </a><a name=\"hcDexamethasoneRatingOutcomeMortality\"> </a><a name=\"DexamethasoneRatingOutcomeMortality-en-US\"> </a><p><b>ArtifactAssessment Version</b>: v4.0</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2020-01-03</p><p><b>artifact</b>: <a href=\"Evidence-DexamethasoneOutcomeMortality.html\">Evidence ExampleOutcomeEvidence</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type Overall}\">Overall certainty</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating moderate}\">Moderate quality</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-importance}\">Clinical Importance</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-clinical-importance 9}\">Critical</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type RiskOfBias}\">Risk of bias</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating serious-concern}\">serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type Inconsistency}\">Inconsistency</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating no-concern}\">no serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type Indirectness}\">Indirectness</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating no-concern}\">no serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type Imprecision}\">Imprecision</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating no-concern}\">no serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type PublicationBias}\">Publication bias</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating no-concern}\">no serious concern</span></p></blockquote></div>"
        },
        "extension" : [
          {
            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-version",
            "valueString" : "v4.0"
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            "url" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-publication-status",
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        "date" : "2020-01-03",
        "artifactReference" : {
          🔗 "reference" : "Evidence/DexamethasoneOutcomeMortality"
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                    "code" : "9",
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                {
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                  "code" : "RiskOfBias",
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                    "code" : "serious-concern",
                    "display" : "serious concern"
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          {
            "informationType" : "rating",
            "type" : {
              "coding" : [
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                  "code" : "Inconsistency",
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      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/outcome-mortality",
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          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Evidence_DexamethasoneOutcomeMortality\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Evidence DexamethasoneOutcomeMortality</b></p><a name=\"DexamethasoneOutcomeMortality\"> </a><a name=\"hcDexamethasoneOutcomeMortality\"> </a><a name=\"DexamethasoneOutcomeMortality-en-US\"> </a><p><b>name</b>: ExampleOutcomeEvidence</p><p><b>status</b>: Active</p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><a href=\"Citation-SystemicCorticosteroidsForTheTreatmentOfCOVID19.html\">Citation SystemicCorticosteroidsForTheTreatmentOfCOVID19</a></td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/variable-role population}\">population</span></p><p><b>observed</b>: <a href=\"Group-StudyCohortCorticosteroidsCOVID19.html\">Group StudyCohortCriteriaSystemicCorticosteroidsCOVID19</a></p><p><b>intended</b>: <a href=\"EvidenceVariable-StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19.html\">EvidenceVariable StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}\">measured variable</span></p><p><b>observed</b>: <a href=\"EvidenceVariable-OutcomeAllCauseMortality.html\">EvidenceVariable AllCauseMortality</a></p></blockquote><p><b>synthesisType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/synthesis-type NotApplicable}\">not applicable</span></p><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>Relative effect of intervention vs. comparator</p>\n</div><p><b>statisticType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/statistic-type C93152}\">Relative Risk</span></p><p><b>quantity</b>: 0.89</p><h3>SampleSizes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>NumberOfStudies</b></td><td><b>NumberOfParticipants</b></td></tr><tr><td style=\"display: none\">*</td><td>9</td><td>7930</td></tr></table><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/attribute-estimate-type C53324}\">Confidence interval</span></td><td>0.95</td><td>0.8-1</td></tr></table></blockquote><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>Baseline risk/result in the comparison group</p>\n</div><p><b>statisticType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/statistic-type C16726}\">Incidence</span></p><p><b>quantity</b>: 245 1/1000<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code1/1000 = '1/1000')</span></p></blockquote></div>"
        },
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              🔗 "reference" : "Citation/SystemicCorticosteroidsForTheTreatmentOfCOVID19"
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                  "code" : "population"
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              ]
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            "observed" : {
              🔗 "reference" : "Group/StudyCohortCorticosteroidsCOVID19"
            },
            "intended" : {
              🔗 "reference" : "EvidenceVariable/StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"
            }
          },
          {
            "variableRole" : {
              "coding" : [
                {
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            "observed" : {
              🔗 "reference" : "EvidenceVariable/OutcomeAllCauseMortality"
            }
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        ],
        "synthesisType" : {
          "coding" : [
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              "system" : "http://terminology.hl7.org/CodeSystem/synthesis-type",
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        "statistic" : [
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            "quantity" : {
              "value" : 0.89
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            "sampleSize" : {
              "numberOfStudies" : 9,
              "numberOfParticipants" : 7930
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            "attributeEstimate" : [
              {
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                "level" : 0.95,
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                  "high" : {
                    "value" : 1
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              "value" : 245,
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      "fullUrl" : "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/study-eligibility-criteria",
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        },
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      "resource" : {
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          "status" : "generated",
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        },
        "name" : "AllCauseMortality",
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                "resourceReference" : {
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        "resourceType" : "Citation",
        "id" : "SystemicCorticosteroidsForTheTreatmentOfCOVID19",
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}