Clinical Practice Guidelines (CPG) on EBMonFHIR
0.8.0-snapshot - ci-build

Clinical Practice Guidelines (CPG) on EBMonFHIR - Local Development build (v0.8.0-snapshot) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions

: COVID19 Intensive Care Treatment Guideline - XML Representation

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<Bundle xmlns="http://hl7.org/fhir">
  <id value="COVID19IntensiveCareTreatmentGuidelineBundle"/>
  <meta>
    <profile
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-bundle"/>
  </meta>
  <type value="collection"/>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/guideline"/>
    <resource>
      <Composition>
        <id value="COVID19IntensiveCareTreatmentGuideline"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Composition_COVID19IntensiveCareTreatmentGuideline"> </a><p><b>Generated Narrative: Composition</b><a name="COVID19IntensiveCareTreatmentGuideline"> </a><a name="hcCOVID19IntensiveCareTreatmentGuideline"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceComposition &quot;COVID19IntensiveCareTreatmentGuideline&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-guideline.html">Clinical Practice Guideline</a></p></div><p><b>identifier</b>: Resource identifier/113-001</p><p><b>version</b>: 7.0</p><p><b>status</b>: final</p><p><b>type</b>: Guidelines <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-code-system.html">CEOsys Code System</a>#clinical-practice-guideline; #e07eN1w1Rwswg4)</span></p><p><b>category</b>: Evidence- and consensus-based guideline <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-guideline-stage-classification.html">Guideline Stage Classification</a>#S3)</span></p><p><b>date</b>: 2022-03-01</p><p><b>author</b>: <a href="Organization-AWMFOrganization.html">Organization/AWMFOrganization</a> &quot;Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) e.V.&quot;</p><p><b>title</b>: Empfehlungen zur stationären Therapie von Patienten mit COVID-19 - Living Guideline</p><h3>RelatesTos</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>citation</td><td>See on this page: Citation/COVID19IntensiveCareTreatmentGuidelineCitation</td></tr></table></div>
        </text>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="RI"/>
              <display value="Resource identifier"/>
            </coding>
          </type>
          <system value="https://www.awmf.org/"/>
          <value value="113-001"/>
        </identifier>
        <version value="7.0"/>
        <status value="final"/>
        <type>
          <coding>
            <system
                    value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
            <code value="clinical-practice-guideline"/>
          </coding>
          <coding>
            <system value="https://data.cochrane.org/concepts/"/>
            <code value="e07eN1w1Rwswg4"/>
            <display value="Guidelines"/>
          </coding>
        </type>
        <category>
          <coding>
            <system
                    value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification"/>
            <code value="S3"/>
            <display value="Evidence- and consensus-based guideline"/>
          </coding>
        </category>
        <date value="2022-03-01"/>
        <author>🔗 
          <reference value="Organization/AWMFOrganization"/>
        </author>
        <title
               value="Empfehlungen zur stationären Therapie von Patienten mit COVID-19 - Living Guideline"/>
        <relatesTo>
          <type value="citation"/>
          <resourceReference>🔗 
            <reference
                       value="Citation/COVID19IntensiveCareTreatmentGuidelineCitation"/>
          </resourceReference>
        </relatesTo>
        <section>
          <title value="Stationäre Therapie von COVID-19 Patienten"/>
          <code>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="guideline-recommendation"/>
              <display value="Clinical practice guideline recommendation"/>
            </coding>
          </code>
          <focus>🔗 
            <reference
                       value="PlanDefinition/COVID19VentilatedPatientsDexamethasoneApplicationPlan"/>
          </focus>
          <text>
            <status value="generated"/>
            <div xmlns="http://www.w3.org/1999/xhtml"><strong>Systemische Steroide:</strong> Bei Patienten mit COVID-19- und Sauerstoff-Bedarf (Niedrigfluss-Sauerstoff-Insufflation, High-Flow Nasal Cannula, Nichtinvasive Beatmung/CPAP, invasive Beatmung) soll eine Therapie mit systemischen Kortikosteroiden erfolgen. Die Therapie sollte mit 6 mg Dexamethason p.o. oder i.v. über zehn Tage erfolgen.</div>
          </text>
        </section>
        <section>
          <title value="Stationäre Therapie von COVID-19 Patienten"/>
          <code>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="guideline-recommendation"/>
              <display value="Clinical practice guideline recommendation"/>
            </coding>
          </code>
          <focus>🔗 
            <reference
                       value="PlanDefinition/COVID19NonVentilatedPatientsDexamethasoneApplicationPlan"/>
          </focus>
          <text>
            <status value="generated"/>
            <div xmlns="http://www.w3.org/1999/xhtml"><strong>Systemische Steroide:</strong> Bei Patienten mit moderater Erkrankung (hospitalisiert ohne Notwendigkeit von Niedrigfluss-Sauerstoff-Insufflation) soll keine Therapie mit systemischen Kortikosteroiden erfolgen.</div>
          </text>
        </section>
      </Composition>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/guideline-citation"/>
    <resource>
      <Citation>
        <id value="COVID19IntensiveCareTreatmentGuidelineCitation"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-citation"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Citation_COVID19IntensiveCareTreatmentGuidelineCitation"> </a><p><b>Generated Narrative: Citation</b><a name="COVID19IntensiveCareTreatmentGuidelineCitation"> </a><a name="hcCOVID19IntensiveCareTreatmentGuidelineCitation"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceCitation &quot;COVID19IntensiveCareTreatmentGuidelineCitation&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-guideline-citation.html">Guideline Citation</a></p></div><p><b>name</b>: COVID19_Intensive_Care_Treatment_Guideline</p><p><b>status</b>: active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://www.awmf.org/</code>/113-001</p><h3>Versions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Value</b></td></tr><tr><td style="display: none">*</td><td>7.0</td></tr></table><p><b>currentState</b>: Active <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-cited-artifact-status-type.html">Cited Artifact Status Type</a>#active)</span></p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td>S3-Leitlinie Stationäre Therapie von COVID-19 Patienten</td></tr></table><h3>WebLocations</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://www.awmf.org/leitlinien/detail/ll/113-001.html">https://www.awmf.org/leitlinien/detail/ll/113-001.html</a></td></tr></table><h3>Classifications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td>Publication Type <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html">Cited Artifact Classification Type</a>#publication-type)</span></td><td>Clinical practice guideline <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-code-system.html">CEOsys Code System</a>#clinical-practice-guideline)</span></td></tr></table></blockquote></div>
        </text>
        <name value="COVID19_Intensive_Care_Treatment_Guideline"/>
        <status value="active"/>
        <citedArtifact>
          <identifier>
            <system value="https://www.awmf.org/"/>
            <value value="113-001"/>
          </identifier>
          <version>
            <value value="7.0"/>
          </version>
          <currentState>
            <coding>
              <system value="http://hl7.org/fhir/cited-artifact-status-type"/>
              <code value="active"/>
              <display value="Active"/>
            </coding>
          </currentState>
          <title>
            <text
                  value="S3-Leitlinie Stationäre Therapie von COVID-19 Patienten"/>
          </title>
          <webLocation>
            <url
                 value="https://www.awmf.org/leitlinien/detail/ll/113-001.html"/>
          </webLocation>
          <classification>
            <type>
              <coding>
                <system
                        value="http://hl7.org/fhir/cited-artifact-classification-type"/>
                <code value="publication-type"/>
                <display value="Publication Type"/>
              </coding>
            </type>
            <classifier>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
                <code value="clinical-practice-guideline"/>
                <display value="Clinical practice guideline"/>
              </coding>
            </classifier>
          </classification>
        </citedArtifact>
      </Citation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation"/>
    <resource>
      <PlanDefinition>
        <id value="COVID19DexamethasoneApplication"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_COVID19DexamethasoneApplication"> </a><p><b>Generated Narrative: PlanDefinition</b><a name="COVID19DexamethasoneApplication"> </a><a name="hcCOVID19DexamethasoneApplication"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourcePlanDefinition &quot;COVID19DexamethasoneApplication&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-recommendation.html">Recommendation</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><blockquote><p><b>Action Combination Method</b></p><blockquote><p><b>url</b></p><code>method</code></blockquote><p><b>value</b>: One or More <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-action-combination-method.html">Action Combination Method</a>#one-or-more)</span></p></blockquote><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation</code></p><p><b>version</b>: 4.0</p><p><b>name</b>: Dexamethasone_Application</p><p><b>title</b>: Dexamethasone Application</p><p><b>type</b>: Workflow Definition <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.5.0/CodeSystem-plan-definition-type.html">PlanDefinitionType</a>#workflow-definition)</span></p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href="EvidenceVariable-PopulationCOVID19Ventilated.html">Population_COVID19_Ventilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: Application of Dexamethasone for ventilated patients only</p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>justification</td><td>Recommendation rating <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-code-system.html">CEOsys Code System</a>#recommendation-rating)</span></td><td>See on this page: ArtifactAssessment/DexamethasoneRecommendationJustification</td></tr><tr><td style="display: none">*</td><td>citation</td><td>Clinical practice guideline recommendation <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-code-system.html">CEOsys Code System</a>#guideline-recommendation)</span></td><td>See on this page: Citation/DexamethasoneRecommendationCitation</td></tr><tr><td style="display: none">*</td><td>citation</td><td>Clinical practice guideline <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-code-system.html">CEOsys Code System</a>#clinical-practice-guideline)</span></td><td>See on this page: Citation/COVID19IntensiveCareTreatmentGuidelineCitation</td></tr></table><blockquote><p><b>action</b></p><p><b>title</b>: Dexamethasone Application</p><p><b>description</b>: Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients</p><p><b>code</b>: Guideline-based Care <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/cpg/STU1/CodeSystem-cpg-common-process.html">CPG Common Process</a>#guideline-based-care)</span></p><p><b>definition</b>: <a href="PlanDefinition-COVID19VentilatedPatientsDexamethasoneApplicationPlan.html">Dexamethasone Application in ventilated COVID-19 patients</a></p></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: No Dexamethasone Application</p><p><b>description</b>: No Dexamethasone Application for non-ventilated COVID-19 patients</p><p><b>code</b>: Guideline-based Care <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/cpg/STU1/CodeSystem-cpg-common-process.html">CPG Common Process</a>#guideline-based-care)</span></p><p><b>definition</b>: <a href="PlanDefinition-COVID19NonVentilatedPatientsDexamethasoneApplicationPlan.html">No Dexamethasone Application for non-ventilated COVID-19 patients</a></p></blockquote></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
          <valueCode value="computable"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
          <valueCode value="structured"/>
        </extension>
        <extension
                   url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method">
          <extension url="method">
            <valueCodeableConcept>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method"/>
                <code value="one-or-more"/>
              </coding>
            </valueCodeableConcept>
          </extension>
        </extension>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation"/>
        <version value="4.0"/>
        <name value="Dexamethasone_Application"/>
        <title value="Dexamethasone Application"/>
        <type>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
            <code value="workflow-definition"/>
          </coding>
        </type>
        <status value="active"/>
        <experimental value="true"/>
        <subjectCanonical
                          value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated"/>
        <date value="2021-12-12"/>
        <publisher value="CPGonEBMonFHIR"/>
        <description
                     value="Application of Dexamethasone for ventilated patients only"/>
        <relatedArtifact>
          <type value="justification"/>
          <classifier>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="recommendation-rating"/>
              <display value="Recommendation rating"/>
            </coding>
          </classifier>
          <resourceReference>🔗 
            <reference
                       value="ArtifactAssessment/DexamethasoneRecommendationJustification"/>
          </resourceReference>
        </relatedArtifact>
        <relatedArtifact>
          <type value="citation"/>
          <classifier>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="guideline-recommendation"/>
              <display value="Clinical practice guideline recommendation"/>
            </coding>
          </classifier>
          <resourceReference>🔗 
            <reference value="Citation/DexamethasoneRecommendationCitation"/>
          </resourceReference>
        </relatedArtifact>
        <relatedArtifact>
          <type value="citation"/>
          <classifier>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="clinical-practice-guideline"/>
              <display value="Clinical practice guideline"/>
            </coding>
          </classifier>
          <resourceReference>🔗 
            <reference
                       value="Citation/COVID19IntensiveCareTreatmentGuidelineCitation"/>
          </resourceReference>
        </relatedArtifact>
        <action>
          <title value="Dexamethasone Application"/>
          <description
                       value="Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients"/>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process"/>
              <code value="guideline-based-care"/>
            </coding>
          </code>
          <definitionCanonical
                               value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-ventilated-patients-dexamethasone-application-plan"/>
        </action>
        <action>
          <title value="No Dexamethasone Application"/>
          <description
                       value="No Dexamethasone Application for non-ventilated COVID-19 patients"/>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process"/>
              <code value="guideline-based-care"/>
            </coding>
          </code>
          <definitionCanonical
                               value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-non-ventilated-patients-no-dexamethasone-application-plan"/>
        </action>
      </PlanDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-plan-ventilated-patients"/>
    <resource>
      <PlanDefinition>
        <id value="COVID19VentilatedPatientsDexamethasoneApplicationPlan"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_COVID19VentilatedPatientsDexamethasoneApplicationPlan"> </a><p><b>Generated Narrative: PlanDefinition</b><a name="COVID19VentilatedPatientsDexamethasoneApplicationPlan"> </a><a name="hcCOVID19VentilatedPatientsDexamethasoneApplicationPlan"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourcePlanDefinition &quot;COVID19VentilatedPatientsDexamethasoneApplicationPlan&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-recommendation-plan.html">Recommendation Plan</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href="PlanDefinition-COVID19DexamethasoneApplication.html">Dexamethasone Application</a></p><blockquote><p><b>Action Combination Method</b></p><blockquote><p><b>url</b></p><code>method</code></blockquote><p><b>value</b>: Exactly <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-action-combination-method.html">Action Combination Method</a>#exactly)</span></p><blockquote><p><b>url</b></p><code>threshold</code></blockquote><p><b>value</b>: 1</p></blockquote><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-ventilated-patients-dexamethasone-application-plan</code></p><p><b>version</b>: 4.0</p><p><b>name</b>: Dexamethasone_Application</p><p><b>title</b>: Dexamethasone Application in ventilated COVID-19 patients</p><p><b>type</b>: ECA Rule <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.5.0/CodeSystem-plan-definition-type.html">PlanDefinitionType</a>#eca-rule)</span></p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href="EvidenceVariable-PopulationCOVID19Ventilated.html">Population_COVID19_Ventilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients</p><blockquote><p><b>action</b></p><p><b>code</b>: Administration of substance (procedure) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#432102000)</span></p><p><b>definition</b>: <a href="Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html">DexamethasoneApplicationActionOral</a></p></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: Administration of substance (procedure) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#432102000)</span></p><p><b>definition</b>: <a href="Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html">DexamethasoneApplicationActionIntravenous</a></p></blockquote></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
          <valueCode value="computable"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
          <valueCode value="structured"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-partOf">
          <valueCanonical
                          value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation"/>
        </extension>
        <extension
                   url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method">
          <extension url="method">
            <valueCodeableConcept>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method"/>
                <code value="exactly"/>
              </coding>
            </valueCodeableConcept>
          </extension>
          <extension url="threshold">
            <valuePositiveInt value="1"/>
          </extension>
        </extension>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-ventilated-patients-dexamethasone-application-plan"/>
        <version value="4.0"/>
        <name value="Dexamethasone_Application"/>
        <title
               value="Dexamethasone Application in ventilated COVID-19 patients"/>
        <type>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
            <code value="eca-rule"/>
          </coding>
        </type>
        <status value="active"/>
        <experimental value="true"/>
        <subjectCanonical
                          value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated"/>
        <date value="2021-12-12"/>
        <publisher value="CPGonEBMonFHIR"/>
        <description
                     value="Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients"/>
        <action>
          <code>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="432102000"/>
              <display value="Administration of substance (procedure)"/>
            </coding>
          </code>
          <definitionCanonical
                               value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral"/>
        </action>
        <action>
          <code>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="432102000"/>
              <display value="Administration of substance (procedure)"/>
            </coding>
          </code>
          <definitionCanonical
                               value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous"/>
        </action>
      </PlanDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-plan-non-ventilated-patients"/>
    <resource>
      <PlanDefinition>
        <id value="COVID19NonVentilatedPatientsDexamethasoneApplicationPlan"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_COVID19NonVentilatedPatientsDexamethasoneApplicationPlan"> </a><p><b>Generated Narrative: PlanDefinition</b><a name="COVID19NonVentilatedPatientsDexamethasoneApplicationPlan"> </a><a name="hcCOVID19NonVentilatedPatientsDexamethasoneApplicationPlan"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourcePlanDefinition &quot;COVID19NonVentilatedPatientsDexamethasoneApplicationPlan&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-recommendation-plan.html">Recommendation Plan</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href="PlanDefinition-COVID19DexamethasoneApplication.html">Dexamethasone Application</a></p><blockquote><p><b>Action Combination Method</b></p><blockquote><p><b>url</b></p><code>method</code></blockquote><p><b>value</b>: Exactly <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-action-combination-method.html">Action Combination Method</a>#exactly)</span></p><blockquote><p><b>url</b></p><code>threshold</code></blockquote><p><b>value</b>: 1</p></blockquote><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-non-ventilated-patients-no-dexamethasone-application-plan</code></p><p><b>version</b>: 4.0</p><p><b>name</b>: No_Dexamethasone_Application</p><p><b>title</b>: No Dexamethasone Application for non-ventilated COVID-19 patients</p><p><b>type</b>: ECA Rule <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.5.0/CodeSystem-plan-definition-type.html">PlanDefinitionType</a>#eca-rule)</span></p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href="EvidenceVariable-PopulationCOVID19NonVentilated.html">Population_COVID19_NonVentilated</a></p><p><b>date</b>: 2021-12-12</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: No Dexamethasone Application for non-ventilated COVID19 patients</p><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Administration of substance (procedure) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#432102000)</span></td><td><a href="Bundle-COVID19IntensiveCareTreatmentGuidelineBundle.html">NoDexamethasoneApplicationActivity</a></td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
          <valueCode value="computable"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
          <valueCode value="structured"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-partOf">
          <valueCanonical
                          value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation"/>
        </extension>
        <extension
                   url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method">
          <extension url="method">
            <valueCodeableConcept>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method"/>
                <code value="exactly"/>
              </coding>
            </valueCodeableConcept>
          </extension>
          <extension url="threshold">
            <valuePositiveInt value="1"/>
          </extension>
        </extension>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-non-ventilated-patients-no-dexamethasone-application-plan"/>
        <version value="4.0"/>
        <name value="No_Dexamethasone_Application"/>
        <title
               value="No Dexamethasone Application for non-ventilated COVID-19 patients"/>
        <type>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
            <code value="eca-rule"/>
          </coding>
        </type>
        <status value="active"/>
        <experimental value="true"/>
        <subjectCanonical
                          value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_NonVentilated"/>
        <date value="2021-12-12"/>
        <publisher value="CPGonEBMonFHIR"/>
        <description
                     value="No Dexamethasone Application for non-ventilated COVID19 patients"/>
        <action>
          <code>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="432102000"/>
              <display value="Administration of substance (procedure)"/>
            </coding>
          </code>
          <definitionCanonical
                               value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application"/>
        </action>
      </PlanDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-oral"/>
    <resource>
      <ActivityDefinition>
        <id value="DexamethasoneApplicationActionOral"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ActivityDefinition_DexamethasoneApplicationActionOral"> </a><p><b>Generated Narrative: ActivityDefinition</b><a name="DexamethasoneApplicationActionOral"> </a><a name="hcDexamethasoneApplicationActionOral"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceActivityDefinition &quot;DexamethasoneApplicationActionOral&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-drug-administration-action.html">Drug Administration Action</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral</code></p><p><b>version</b>: 1.0</p><p><b>name</b>: DexamethasoneApplicationActionOral</p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: Patient <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-fhir-types.html">All FHIR Types</a>#Patient)</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: Application of Dexamethasone: 6 mg once per day for 10 days (oral route)</p><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: Administration of substance (procedure) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#432102000)</span></p><p><b>product</b>: Dexamethasone (substance) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#372584003; atc#C05AA09 &quot;Dexamethason&quot;)</span></p><blockquote><p><b>dosage</b></p><p><b>timing</b>: Count 10  times, Duration 10days , Once per 1 days</p><p><b>route</b>: Oral route <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#26643006)</span></p><blockquote><p><b>doseAndRate</b></p></blockquote></blockquote></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
          <valueCode value="computable"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
          <valueCode value="structured"/>
        </extension>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral"/>
        <version value="1.0"/>
        <name value="DexamethasoneApplicationActionOral"/>
        <status value="active"/>
        <experimental value="true"/>
        <subjectCodeableConcept>
          <coding>
            <system value="http://hl7.org/fhir/fhir-types"/>
            <code value="Patient"/>
          </coding>
        </subjectCodeableConcept>
        <publisher value="CPGonEBMonFHIR"/>
        <description
                     value="Application of Dexamethasone: 6 mg once per day for 10 days (oral route)"/>
        <kind value="MedicationRequest"/>
        <code>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="432102000"/>
            <display value="Administration of substance (procedure)"/>
          </coding>
        </code>
        <productCodeableConcept>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="372584003"/>
            <display value="Dexamethasone (substance)"/>
          </coding>
          <coding>
            <system value="http://fhir.de/CodeSystem/bfarm/atc"/>
            <code value="C05AA09"/>
            <display value="Dexamethason"/>
          </coding>
        </productCodeableConcept>
        <dosage>
          <timing>
            <repeat>
              <count value="10"/>
              <duration value="10"/>
              <durationUnit value="d"/>
              <frequency value="1"/>
              <period value="1"/>
              <periodUnit value="d"/>
            </repeat>
          </timing>
          <route>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="26643006"/>
              <display value="Oral route"/>
            </coding>
          </route>
          <doseAndRate>
            <doseQuantity>
              <value value="6"/>
              <unit value="mg"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="mg"/>
            </doseQuantity>
            <rateQuantity>
              <value value="1"/>
              <unit value="/d"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="/d"/>
            </rateQuantity>
          </doseAndRate>
        </dosage>
      </ActivityDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-intravenous"/>
    <resource>
      <ActivityDefinition>
        <id value="DexamethasoneApplicationActionIntravenous"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ActivityDefinition_DexamethasoneApplicationActionIntravenous"> </a><p><b>Generated Narrative: ActivityDefinition</b><a name="DexamethasoneApplicationActionIntravenous"> </a><a name="hcDexamethasoneApplicationActionIntravenous"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceActivityDefinition &quot;DexamethasoneApplicationActionIntravenous&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-drug-administration-action.html">Drug Administration Action</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous</code></p><p><b>version</b>: 1.0</p><p><b>name</b>: DexamethasoneApplicationActionIntravenous</p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: Patient <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-fhir-types.html">All FHIR Types</a>#Patient)</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: Application of Dexamethasone: 6 mg once per day for 10 days (intravenous route)</p><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: Administration of substance (procedure) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#432102000)</span></p><p><b>product</b>: Dexamethasone (substance) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#372584003; atc#C05AA09 &quot;Dexamethason&quot;)</span></p><blockquote><p><b>dosage</b></p><p><b>timing</b>: Count 10  times, Duration 10days , Once per 1 days</p><p><b>route</b>: Intravenous route <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#47625008)</span></p><blockquote><p><b>doseAndRate</b></p></blockquote></blockquote></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
          <valueCode value="computable"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
          <valueCode value="structured"/>
        </extension>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous"/>
        <version value="1.0"/>
        <name value="DexamethasoneApplicationActionIntravenous"/>
        <status value="active"/>
        <experimental value="true"/>
        <subjectCodeableConcept>
          <coding>
            <system value="http://hl7.org/fhir/fhir-types"/>
            <code value="Patient"/>
          </coding>
        </subjectCodeableConcept>
        <publisher value="CPGonEBMonFHIR"/>
        <description
                     value="Application of Dexamethasone: 6 mg once per day for 10 days (intravenous route)"/>
        <kind value="MedicationRequest"/>
        <code>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="432102000"/>
            <display value="Administration of substance (procedure)"/>
          </coding>
        </code>
        <productCodeableConcept>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="372584003"/>
            <display value="Dexamethasone (substance)"/>
          </coding>
          <coding>
            <system value="http://fhir.de/CodeSystem/bfarm/atc"/>
            <code value="C05AA09"/>
            <display value="Dexamethason"/>
          </coding>
        </productCodeableConcept>
        <dosage>
          <timing>
            <repeat>
              <count value="10"/>
              <duration value="10"/>
              <durationUnit value="d"/>
              <frequency value="1"/>
              <period value="1"/>
              <periodUnit value="d"/>
            </repeat>
          </timing>
          <route>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="47625008"/>
              <display value="Intravenous route"/>
            </coding>
          </route>
          <doseAndRate>
            <doseQuantity>
              <value value="6"/>
              <unit value="mg"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="mg"/>
            </doseQuantity>
            <rateQuantity>
              <value value="1"/>
              <unit value="/d"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="/d"/>
            </rateQuantity>
          </doseAndRate>
        </dosage>
      </ActivityDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-no-application"/>
    <resource>
      <ActivityDefinition>
        <id value="NoDexamethasoneApplication"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ActivityDefinition_NoDexamethasoneApplication"> </a><p><b>Generated Narrative: ActivityDefinition</b><a name="NoDexamethasoneApplication"> </a><a name="hcNoDexamethasoneApplication"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceActivityDefinition &quot;NoDexamethasoneApplication&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-drug-administration-action.html">Drug Administration Action</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application</code></p><p><b>version</b>: 1.0</p><p><b>name</b>: NoDexamethasoneApplicationActivity</p><p><b>status</b>: active</p><p><b>experimental</b>: true</p><p><b>subject</b>: Patient <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-fhir-types.html">All FHIR Types</a>#Patient)</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: No Application of Dexamethasone</p><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: Administration of substance (procedure) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#432102000)</span></p><p><b>doNotPerform</b>: true</p><p><b>product</b>: Dexamethasone (substance) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#372584003; atc#C05AA09 &quot;Dexamethason&quot;)</span></p></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
          <valueCode value="computable"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
          <valueCode value="structured"/>
        </extension>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application"/>
        <version value="1.0"/>
        <name value="NoDexamethasoneApplicationActivity"/>
        <status value="active"/>
        <experimental value="true"/>
        <subjectCodeableConcept>
          <coding>
            <system value="http://hl7.org/fhir/fhir-types"/>
            <code value="Patient"/>
          </coding>
        </subjectCodeableConcept>
        <publisher value="CPGonEBMonFHIR"/>
        <description value="No Application of Dexamethasone"/>
        <kind value="MedicationRequest"/>
        <code>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="432102000"/>
            <display value="Administration of substance (procedure)"/>
          </coding>
        </code>
        <doNotPerform value="true"/>
        <productCodeableConcept>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="372584003"/>
            <display value="Dexamethasone (substance)"/>
          </coding>
          <coding>
            <system value="http://fhir.de/CodeSystem/bfarm/atc"/>
            <code value="C05AA09"/>
            <display value="Dexamethason"/>
          </coding>
        </productCodeableConcept>
      </ActivityDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-citation"/>
    <resource>
      <Citation>
        <id value="DexamethasoneRecommendationCitation"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-citation"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Citation_DexamethasoneRecommendationCitation"> </a><p><b>Generated Narrative: Citation</b><a name="DexamethasoneRecommendationCitation"> </a><a name="hcDexamethasoneRecommendationCitation"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceCitation &quot;DexamethasoneRecommendationCitation&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-recommendation-citation.html">Recommendation Citation</a></p></div><p><b>name</b>: DexamethasoneRecommendationCitation</p><p><b>status</b>: active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://api.magicapp.org/api/v1/recommendations</code>/98398</p><h3>Versions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Value</b></td></tr><tr><td style="display: none">*</td><td>v4.0</td></tr></table><p><b>currentState</b>: Active <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-cited-artifact-status-type.html">Cited Artifact Status Type</a>#active)</span></p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td>Steroide</td></tr></table><h3>Classifications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td>Publication Type <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html">Cited Artifact Classification Type</a>#publication-type)</span></td><td>Clinical practice guideline recommendation <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-code-system.html">CEOsys Code System</a>#guideline-recommendation)</span></td></tr></table></blockquote></div>
        </text>
        <name value="DexamethasoneRecommendationCitation"/>
        <status value="active"/>
        <citedArtifact>
          <identifier>
            <system value="https://api.magicapp.org/api/v1/recommendations"/>
            <value value="98398"/>
          </identifier>
          <version>
            <value value="v4.0"/>
          </version>
          <currentState>
            <coding>
              <system value="http://hl7.org/fhir/cited-artifact-status-type"/>
              <code value="active"/>
              <display value="Active"/>
            </coding>
          </currentState>
          <title>
            <text value="Steroide"/>
          </title>
          <classification>
            <type>
              <coding>
                <system
                        value="http://hl7.org/fhir/cited-artifact-classification-type"/>
                <code value="publication-type"/>
                <display value="Publication Type"/>
              </coding>
            </type>
            <classifier>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
                <code value="guideline-recommendation"/>
                <display value="Clinical practice guideline recommendation"/>
              </coding>
            </classifier>
          </classification>
        </citedArtifact>
      </Citation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/evidence-variable-ventilated"/>
    <resource>
      <EvidenceVariable>
        <id value="PopulationCOVID19Ventilated"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-eligibility-criteria"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_PopulationCOVID19Ventilated"> </a><p><b>Generated Narrative: EvidenceVariable</b><a name="PopulationCOVID19Ventilated"> </a><a name="hcPopulationCOVID19Ventilated"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceEvidenceVariable &quot;PopulationCOVID19Ventilated&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-recommendation-eligibility-criteria.html">Recommendation Eligibility Criteria</a></p></div><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated</code></p><p><b>identifier</b>: <code>https://www.ceosys.de</code>/Ventilated</p><p><b>name</b>: Population_COVID19_Ventilated</p><p><b>status</b>: active</p><p><b>description</b>: Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, Ventilated</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: covid19</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Clinical finding (finding) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#404684003)</span></td><td>Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#840539006)</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: any-of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: oxy-administration-nasal-cannula</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: noninvasive-ventilation</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: artificial-respiration</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote></blockquote></blockquote></div>
        </text>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated"/>
        <identifier>
          <system value="https://www.ceosys.de"/>
          <value value="Ventilated"/>
        </identifier>
        <name value="Population_COVID19_Ventilated"/>
        <status value="active"/>
        <description
                     value="Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, Ventilated"/>
        <characteristic>
          <linkId value="covid19"/>
          <definitionByTypeAndValue>
            <type>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="404684003"/>
                <display value="Clinical finding (finding)"/>
              </coding>
            </type>
            <valueCodeableConcept>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="840539006"/>
                <display
                         value="Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"/>
              </coding>
            </valueCodeableConcept>
          </definitionByTypeAndValue>
        </characteristic>
        <characteristic>
          <exclude value="false"/>
          <definitionByCombination>
            <code value="any-of"/>
            <characteristic>
              <linkId value="oxy-administration-nasal-cannula"/>
              <exclude value="false"/>
              <definitionByTypeAndValue>
                <type>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="71388002"/>
                    <display value="Procedure (procedure)"/>
                  </coding>
                </type>
                <valueCodeableConcept>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="371907003"/>
                    <display
                             value="Oxygen administration by nasal cannula (procedure)"/>
                  </coding>
                </valueCodeableConcept>
              </definitionByTypeAndValue>
              <timeFromEvent>
                <eventId value="covid19"/>
                <quantity>
                  <value value="0"/>
                  <system value="http://unitsofmeasure.org"/>
                  <code value="d"/>
                </quantity>
              </timeFromEvent>
            </characteristic>
            <characteristic>
              <linkId value="noninvasive-ventilation"/>
              <exclude value="false"/>
              <definitionByTypeAndValue>
                <type>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="71388002"/>
                    <display value="Procedure (procedure)"/>
                  </coding>
                </type>
                <valueCodeableConcept>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="428311008"/>
                    <display
                             value="Non-invasive ventilation (regime/therapy)"/>
                  </coding>
                </valueCodeableConcept>
              </definitionByTypeAndValue>
              <timeFromEvent>
                <eventId value="covid19"/>
                <quantity>
                  <value value="0"/>
                  <system value="http://unitsofmeasure.org"/>
                  <code value="d"/>
                </quantity>
              </timeFromEvent>
            </characteristic>
            <characteristic>
              <linkId value="artificial-respiration"/>
              <exclude value="false"/>
              <definitionByTypeAndValue>
                <type>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="71388002"/>
                    <display value="Procedure (procedure)"/>
                  </coding>
                </type>
                <valueCodeableConcept>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="40617009"/>
                    <display value="Artificial ventilation (regime/therapy)"/>
                  </coding>
                </valueCodeableConcept>
              </definitionByTypeAndValue>
              <timeFromEvent>
                <eventId value="covid19"/>
                <quantity>
                  <value value="0"/>
                  <system value="http://unitsofmeasure.org"/>
                  <code value="d"/>
                </quantity>
              </timeFromEvent>
            </characteristic>
          </definitionByCombination>
        </characteristic>
      </EvidenceVariable>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/evidence-variable-non-ventilated"/>
    <resource>
      <EvidenceVariable>
        <id value="PopulationCOVID19NonVentilated"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-eligibility-criteria"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_PopulationCOVID19NonVentilated"> </a><p><b>Generated Narrative: EvidenceVariable</b><a name="PopulationCOVID19NonVentilated"> </a><a name="hcPopulationCOVID19NonVentilated"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceEvidenceVariable &quot;PopulationCOVID19NonVentilated&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-recommendation-eligibility-criteria.html">Recommendation Eligibility Criteria</a></p></div><p><b>url</b>: <code>https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_NonVentilated</code></p><p><b>identifier</b>: <code>https://www.ceosys.de</code>/NonVentilated</p><p><b>name</b>: Population_COVID19_NonVentilated</p><p><b>status</b>: active</p><p><b>description</b>: Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, not ventilated</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: covid19</p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Clinical finding (finding) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#404684003)</span></td><td>Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#840539006)</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>exclude</b>: true</p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: any-of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: oxy-administration-nasal-cannula</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: noninvasive-ventilation</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: artificial-respiration</p><p><b>exclude</b>: false</p><blockquote><p><b>definitionByTypeAndValue</b></p></blockquote><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote></blockquote></blockquote></div>
        </text>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_NonVentilated"/>
        <identifier>
          <system value="https://www.ceosys.de"/>
          <value value="NonVentilated"/>
        </identifier>
        <name value="Population_COVID19_NonVentilated"/>
        <status value="active"/>
        <description
                     value="Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, not ventilated"/>
        <characteristic>
          <linkId value="covid19"/>
          <exclude value="false"/>
          <definitionByTypeAndValue>
            <type>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="404684003"/>
                <display value="Clinical finding (finding)"/>
              </coding>
            </type>
            <valueCodeableConcept>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="840539006"/>
                <display
                         value="Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"/>
              </coding>
            </valueCodeableConcept>
          </definitionByTypeAndValue>
        </characteristic>
        <characteristic>
          <exclude value="true"/>
          <definitionByCombination>
            <code value="any-of"/>
            <characteristic>
              <linkId value="oxy-administration-nasal-cannula"/>
              <exclude value="false"/>
              <definitionByTypeAndValue>
                <type>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="71388002"/>
                    <display value="Procedure (procedure)"/>
                  </coding>
                </type>
                <valueCodeableConcept>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="371907003"/>
                    <display
                             value="Oxygen administration by nasal cannula (procedure)"/>
                  </coding>
                </valueCodeableConcept>
              </definitionByTypeAndValue>
              <timeFromEvent>
                <eventId value="covid19"/>
                <quantity>
                  <value value="0"/>
                  <system value="http://unitsofmeasure.org"/>
                  <code value="d"/>
                </quantity>
              </timeFromEvent>
            </characteristic>
            <characteristic>
              <linkId value="noninvasive-ventilation"/>
              <exclude value="false"/>
              <definitionByTypeAndValue>
                <type>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="71388002"/>
                    <display value="Procedure (procedure)"/>
                  </coding>
                </type>
                <valueCodeableConcept>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="428311008"/>
                    <display
                             value="Non-invasive ventilation (regime/therapy)"/>
                  </coding>
                </valueCodeableConcept>
              </definitionByTypeAndValue>
              <timeFromEvent>
                <eventId value="covid19"/>
                <quantity>
                  <value value="0"/>
                  <system value="http://unitsofmeasure.org"/>
                  <code value="d"/>
                </quantity>
              </timeFromEvent>
            </characteristic>
            <characteristic>
              <linkId value="artificial-respiration"/>
              <exclude value="false"/>
              <definitionByTypeAndValue>
                <type>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="71388002"/>
                    <display value="Procedure (procedure)"/>
                  </coding>
                </type>
                <valueCodeableConcept>
                  <coding>
                    <system value="http://snomed.info/sct"/>
                    <code value="40617009"/>
                    <display value="Artificial ventilation (regime/therapy)"/>
                  </coding>
                </valueCodeableConcept>
              </definitionByTypeAndValue>
              <timeFromEvent>
                <eventId value="covid19"/>
                <quantity>
                  <value value="0"/>
                  <system value="http://unitsofmeasure.org"/>
                  <code value="d"/>
                </quantity>
              </timeFromEvent>
            </characteristic>
          </definitionByCombination>
        </characteristic>
      </EvidenceVariable>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/rating-outcome-mortality"/>
    <resource>
      <ArtifactAssessment>
        <id value="DexamethasoneRatingOutcomeMortality"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/certainty-of-evidence-rating"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ArtifactAssessment_DexamethasoneRatingOutcomeMortality"> </a><p><b>Generated Narrative: ArtifactAssessment</b><a name="DexamethasoneRatingOutcomeMortality"> </a><a name="hcDexamethasoneRatingOutcomeMortality"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceArtifactAssessment &quot;DexamethasoneRatingOutcomeMortality&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-certainty-of-evidence-rating.html">Certainty of Evidence Rating</a></p></div><p><b>ArtifactAssessment Version</b>: v4.0</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2020-01-03</p><p><b>artifact</b>: See on this page: Evidence/DexamethasoneOutcomeMortality</p><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Overall certainty <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-certainty-type.html">Evidence Certainty Type</a>#Overall)</span></p><p><b>classifier</b>: Moderate quality <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-certainty-rating.html">Evidence Certainty Rating</a>#moderate)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Clinical Importance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-code-system.html">CEOsys Code System</a>#clinical-importance)</span></p><p><b>classifier</b>: Critical <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-clinical-importance.html">Clinical Importance of Outcome</a>#9)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Risk of bias <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-certainty-type.html">Evidence Certainty Type</a>#RiskOfBias)</span></p><p><b>classifier</b>: serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-certainty-rating.html">Evidence Certainty Rating</a>#serious-concern)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Inconsistency <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-certainty-type.html">Evidence Certainty Type</a>#Inconsistency)</span></p><p><b>classifier</b>: no serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-certainty-rating.html">Evidence Certainty Rating</a>#no-concern)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Indirectness <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-certainty-type.html">Evidence Certainty Type</a>#Indirectness)</span></p><p><b>classifier</b>: no serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-certainty-rating.html">Evidence Certainty Rating</a>#no-concern)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Imprecision <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-certainty-type.html">Evidence Certainty Type</a>#Imprecision)</span></p><p><b>classifier</b>: no serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-certainty-rating.html">Evidence Certainty Rating</a>#no-concern)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Publication bias <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-certainty-type.html">Evidence Certainty Type</a>#PublicationBias)</span></p><p><b>classifier</b>: no serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-certainty-rating.html">Evidence Certainty Rating</a>#no-concern)</span></p></blockquote></div>
        </text>
        <extension
                   url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-version">
          <valueString value="v4.0"/>
        </extension>
        <extension
                   url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-publication-status">
          <valueCode value="active"/>
        </extension>
        <date value="2020-01-03"/>
        <artifactReference>🔗 
          <reference value="Evidence/DexamethasoneOutcomeMortality"/>
        </artifactReference>
        <content>
          <informationType value="rating"/>
          <type>
            <coding>
              <system value="http://hl7.org/fhir/certainty-type"/>
              <code value="Overall"/>
              <display value="Overall certainty"/>
            </coding>
          </type>
          <classifier>
            <coding>
              <system value="http://hl7.org/fhir/certainty-rating"/>
              <code value="moderate"/>
              <display value="Moderate quality"/>
            </coding>
          </classifier>
        </content>
        <content>
          <informationType value="rating"/>
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              <system
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            <coding>
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          <informationType value="rating"/>
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          <informationType value="rating"/>
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              <code value="Imprecision"/>
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            <coding>
              <system value="http://hl7.org/fhir/certainty-rating"/>
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          <informationType value="rating"/>
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  <entry>
    <fullUrl
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    <resource>
      <Evidence>
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        <meta>
          <profile
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        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Evidence_DexamethasoneOutcomeMortality"> </a><p><b>Generated Narrative: Evidence</b><a name="DexamethasoneOutcomeMortality"> </a><a name="hcDexamethasoneOutcomeMortality"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceEvidence &quot;DexamethasoneOutcomeMortality&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-outcome-evidence-synthesis.html">Outcome Evidence Synthesis</a></p></div><p><b>name</b>: ExampleOutcomeEvidence</p><p><b>status</b>: active</p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>citation</td><td>See on this page: Citation/SystemicCorticosteroidsForTheTreatmentOfCOVID19</td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: population <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.5.0/CodeSystem-variable-role.html">EvidenceVariableRole</a>#population)</span></p><p><b>observed</b>: <a href="Group-StudyCohortCorticosteroidsCOVID19.html">Group/StudyCohortCorticosteroidsCOVID19</a> &quot;StudyCohortCriteriaSystemicCorticosteroidsCOVID19&quot;</p><p><b>intended</b>: See on this page: EvidenceVariable/StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: measured variable <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.5.0/CodeSystem-variable-role.html">EvidenceVariableRole</a>#measuredVariable)</span></p><p><b>observed</b>: See on this page: EvidenceVariable/OutcomeAllCauseMortality</p></blockquote><p><b>synthesisType</b>: not applicable <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-synthesis-type.html">SynthesisType</a>#NotApplicable)</span></p><blockquote><p><b>statistic</b></p><p><b>description</b>: Relative effect of intervention vs. comparator</p><p><b>statisticType</b>: Relative Risk <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.5.0/CodeSystem-statistic-type.html">StatisticStatisticType</a>#C93152)</span></p><p><b>quantity</b>: 0.89</p><h3>SampleSizes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>NumberOfStudies</b></td><td><b>NumberOfParticipants</b></td></tr><tr><td style="display: none">*</td><td>9</td><td>7930</td></tr></table><h3>AttributeEstimates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td>Confidence interval <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.5.0/CodeSystem-attribute-estimate-type.html">StatisticAttribute Estimate Type</a>#C53324)</span></td><td>0.95</td><td>0.8-1</td></tr></table></blockquote><blockquote><p><b>statistic</b></p><p><b>description</b>: Baseline risk/result in the comparison group</p><p><b>statisticType</b>: Incidence <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.5.0/CodeSystem-statistic-type.html">StatisticStatisticType</a>#C16726)</span></p><p><b>quantity</b>: 245 1/1000<span style="background: LightGoldenRodYellow"> (Details: UCUM code 1/1000 = '1/1000')</span></p></blockquote></div>
        </text>
        <name value="ExampleOutcomeEvidence"/>
        <status value="active"/>
        <relatedArtifact>
          <type value="citation"/>
          <resourceReference>🔗 
            <reference
                       value="Citation/SystemicCorticosteroidsForTheTreatmentOfCOVID19"/>
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            <coding>
              <system
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              <code value="population"/>
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          </variableRole>
          <observed>🔗 
            <reference value="Group/StudyCohortCorticosteroidsCOVID19"/>
          </observed>
          <intended>🔗 
            <reference
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            <coding>
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              <code value="measuredVariable"/>
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          <observed>🔗 
            <reference value="EvidenceVariable/OutcomeAllCauseMortality"/>
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        <synthesisType>
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            <system
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              <code value="C93152"/>
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          <quantity>
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          <sampleSize>
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            <numberOfParticipants value="7930"/>
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          <attributeEstimate>
            <type>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/attribute-estimate-type"/>
                <code value="C53324"/>
                <display value="Confidence interval"/>
              </coding>
            </type>
            <level value="0.95"/>
            <range>
              <low>
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              <high>
                <value value="1"/>
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              <code value="C16726"/>
              <display value="Incidence"/>
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          <quantity>
            <value value="245"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="1/1000"/>
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  </entry>
  <entry>
    <fullUrl
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    <resource>
      <EvidenceVariable>
        <id value="StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"/>
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          <div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"> </a><p><b>Generated Narrative: EvidenceVariable</b><a name="StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"> </a><a name="hcStudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceEvidenceVariable &quot;StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-study-eligibility-criteria.html">Study Eligibility Criteria</a></p></div><p><b>name</b>: StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19</p><p><b>status</b>: active</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Clinical finding (finding) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#404684003)</span></td><td>Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#840539006)</span></td></tr></table></blockquote></div>
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        <name value="StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"/>
        <status value="active"/>
        <characteristic>
          <definitionByTypeAndValue>
            <type>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="404684003"/>
                <display value="Clinical finding (finding)"/>
              </coding>
            </type>
            <valueCodeableConcept>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="840539006"/>
                <display
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          </definitionByTypeAndValue>
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  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/outcome-all-cause-mortality"/>
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      <EvidenceVariable>
        <id value="OutcomeAllCauseMortality"/>
        <meta>
          <profile
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          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_OutcomeAllCauseMortality"> </a><p><b>Generated Narrative: EvidenceVariable</b><a name="OutcomeAllCauseMortality"> </a><a name="hcOutcomeAllCauseMortality"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceEvidenceVariable &quot;OutcomeAllCauseMortality&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-outcome-definition.html">Outcome Definition</a></p></div><p><b>name</b>: AllCauseMortality</p><p><b>status</b>: active</p><h3>Characteristics</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Exclude</b></td><td><b>DefinitionCodeableConcept</b></td></tr><tr><td style="display: none">*</td><td>false</td><td>Mortality rate (observable entity) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOWMED CT</a>#409651001)</span></td></tr></table><p><b>handling</b>: dichotomous</p></div>
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        <name value="AllCauseMortality"/>
        <status value="active"/>
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          <exclude value="false"/>
          <definitionCodeableConcept>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="409651001"/>
              <display value="Mortality rate (observable entity)"/>
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        <handling value="dichotomous"/>
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  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-justification"/>
    <resource>
      <ArtifactAssessment>
        <id value="DexamethasoneRecommendationJustification"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-justification"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ArtifactAssessment_DexamethasoneRecommendationJustification"> </a><p><b>Generated Narrative: ArtifactAssessment</b><a name="DexamethasoneRecommendationJustification"> </a><a name="hcDexamethasoneRecommendationJustification"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">ResourceArtifactAssessment &quot;DexamethasoneRecommendationJustification&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-recommendation-justification.html">Recommendation Justification</a></p></div><p><b>ArtifactAssessment Version</b>: v4.0</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2020-01-03</p><p><b>artifact</b>: See on this page: PlanDefinition/COVID19VentilatedPatientsDexamethasoneApplicationPlan</p><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Strength of recommendation <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-code-system.html">CEOsys Code System</a>#strength)</span></p><p><b>classifier</b>: Strong for an intervention <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-cs-recommendation-strength.html">Recommendation Strength</a>#strong-for)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Consensus <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-code-system.html">CEOsys Code System</a>#consensus)</span></p><p><b>classifier</b>: Strong <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.5.0/CodeSystem-recommendation-strength.html">StrengthOfRecommendationRating</a>#strong)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Preference and values <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-evidence-to-decision-certainty-type.html">Evidence To Decision Certainty type</a>#preference-and-values)</span></p><p><b>classifier</b>: Factor not considered <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-evidence-to-decision-certainty-rating.html">Evidence To Decision Certainty Rating</a>#factor-not-considered)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Resources <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-evidence-to-decision-certainty-type.html">Evidence To Decision Certainty type</a>#resources)</span></p><p><b>classifier</b>: No important issues <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-evidence-to-decision-certainty-rating.html">Evidence To Decision Certainty Rating</a>#no-important-issues)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Acceptability <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-evidence-to-decision-certainty-type.html">Evidence To Decision Certainty type</a>#acceptability)</span></p><p><b>classifier</b>: Factor not considered <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-evidence-to-decision-certainty-rating.html">Evidence To Decision Certainty Rating</a>#factor-not-considered)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>type</b>: Feasibility <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-evidence-to-decision-certainty-type.html">Evidence To Decision Certainty type</a>#feasibility)</span></p><p><b>classifier</b>: Factor not considered <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-evidence-to-decision-certainty-rating.html">Evidence To Decision Certainty Rating</a>#factor-not-considered)</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: container</p><p><b>type</b>: Certainty of evidence rating <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-code-system.html">CEOsys Code System</a>#certainty-of-evidence-rating)</span></p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>justification</td><td>Certainty of evidence rating <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-ceosys-code-system.html">CEOsys Code System</a>#certainty-of-evidence-rating)</span></td><td>See on this page: ArtifactAssessment/DexamethasoneRatingOutcomeMortality</td></tr></table></blockquote></div>
        </text>
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        <extension
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          <valueCode value="active"/>
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        <date value="2020-01-03"/>
        <artifactReference>🔗 
          <reference
                     value="PlanDefinition/COVID19VentilatedPatientsDexamethasoneApplicationPlan"/>
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          <informationType value="rating"/>
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              <system
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              <code value="strength"/>
              <display value="Strength of recommendation"/>
            </coding>
          </type>
          <classifier>
            <coding>
              <system
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              <code value="strong-for"/>
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          </classifier>
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        <content>
          <informationType value="rating"/>
          <type>
            <coding>
              <system
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              <code value="consensus"/>
              <display value="Consensus"/>
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          <classifier>
            <coding>
              <system
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              <code value="strong"/>
              <display value="Strong"/>
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        <content>
          <informationType value="rating"/>
          <type>
            <coding>
              <system
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              <code value="preference-and-values"/>
              <display value="Preference and values"/>
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          <classifier>
            <coding>
              <system
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              <code value="factor-not-considered"/>
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              <code value="no-important-issues"/>
              <display value="No important issues"/>
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        <content>
          <informationType value="rating"/>
          <type>
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