DE.NETZWERK-UNIVERSITAETSMEDIZIN.EBM-CPG\COVID19 Intensive Care Treatment Guideline

Clinical Practice Guidelines (CPG) on EBMonFHIR - Local Development build (v0.8.0-snapshot) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions

Example Bundle: COVID19 Intensive Care Treatment Guideline

Bundle COVID19IntensiveCareTreatmentGuidelineBundle of type collection

Entry 1 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/guideline

Resource Composition:

Generated Narrative: Composition
ResourceComposition "COVID19IntensiveCareTreatmentGuideline"
Profile: Clinical Practice Guideline
identifier: Resource identifier/113-001
version: 7.0
status: FINAL
type: Guidelines (CEOsys Code System#clinical-practice-guideline; #e07eN1w1Rwswg4)
category: Evidence- and consensus-based guideline (Guideline Stage Classification#S3)
date: 2022-03-01
author: Organization/AWMFOrganization "Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) e.V."
title: Empfehlungen zur stationären Therapie von Patienten mit COVID-19 - Living Guideline
RelatesTos
- Type ResourceReference
* CITATION See on this page: Citation/COVID19IntensiveCareTreatmentGuidelineCitation

Entry 2 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/guideline-citation

Resource Citation:

Generated Narrative: Citation
ResourceCitation "COVID19IntensiveCareTreatmentGuidelineCitation"
Profile: Guideline Citation
name: COVID19_Intensive_Care_Treatment_Guideline
status: ACTIVE
citedArtifact
identifier: https://www.awmf.org//113-001
Versions
- Value
* 7.0
currentState: Active (Cited Artifact Status Type#active)
Titles
- Text
* S3-Leitlinie Stationäre Therapie von COVID-19 Patienten
WebLocations
- Url
* https://www.awmf.org/leitlinien/detail/ll/113-001.html
Classifications
- Type Classifier
* Publication Type (Cited Artifact Classification Type#publication-type) Clinical practice guideline (CEOsys Code System#clinical-practice-guideline)

Entry 3 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation

Resource PlanDefinition:

Generated Narrative: PlanDefinition
ResourcePlanDefinition "COVID19DexamethasoneApplication"
Profile: Recommendation
knowledgeCapability: computable
knowledgeRepresentationLevel: structured
Action Combination Method
url
method
value: One or More (Action Combination Method#one-or-more)
url: https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-dexamethasone-recommendation
version: 4.0
name: Dexamethasone_Application
title: Dexamethasone Application
type: Workflow Definition (PlanDefinitionType#workflow-definition)
status: ACTIVE
experimental: true
subject: Population_COVID19_Ventilated
date: 2021-12-12
publisher: CPGonEBMonFHIR
description: Application of Dexamethasone for ventilated patients only
RelatedArtifacts
- Type Classifier ResourceReference
* JUSTIFICATION Recommendation rating (CEOsys Code System#recommendation-rating) See on this page: ArtifactAssessment/DexamethasoneRecommendationJustification
* CITATION Clinical practice guideline recommendation (CEOsys Code System#guideline-recommendation) See on this page: Citation/DexamethasoneRecommendationCitation
* CITATION Clinical practice guideline (CEOsys Code System#clinical-practice-guideline) See on this page: Citation/COVID19IntensiveCareTreatmentGuidelineCitation
action
title: Dexamethasone Application
description: Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients
code: Guideline-based Care (CPG Common Process#guideline-based-care)
definition: Dexamethasone Application in ventilated COVID-19 patients
action
title: No Dexamethasone Application
description: No Dexamethasone Application for non-ventilated COVID-19 patients
code: Guideline-based Care (CPG Common Process#guideline-based-care)
definition: No Dexamethasone Application for non-ventilated COVID-19 patients

Entry 4 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-plan-ventilated-patients

Resource PlanDefinition:

Generated Narrative: PlanDefinition
ResourcePlanDefinition "COVID19VentilatedPatientsDexamethasoneApplicationPlan"
Profile: Recommendation Plan
knowledgeCapability: computable
knowledgeRepresentationLevel: structured
partOf: Dexamethasone Application
Action Combination Method
url
method
value: Exactly (Action Combination Method#exactly)
url
threshold
value: 1
url: https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-ventilated-patients-dexamethasone-application-plan
version: 4.0
name: Dexamethasone_Application
title: Dexamethasone Application in ventilated COVID-19 patients
type: ECA Rule (PlanDefinitionType#eca-rule)
status: ACTIVE
experimental: true
subject: Population_COVID19_Ventilated
date: 2021-12-12
publisher: CPGonEBMonFHIR
description: Application of Dexamethasone: 6 mg once per day for 10 days p.o. or i.v. for ventilated COVID-19 patients
action
code: Administration of substance (procedure) (SNOWMED CT#432102000)
definition: DexamethasoneApplicationActionOral
action
code: Administration of substance (procedure) (SNOWMED CT#432102000)
definition: DexamethasoneApplicationActionIntravenous

Entry 5 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-plan-non-ventilated-patients

Resource PlanDefinition:

Generated Narrative: PlanDefinition
ResourcePlanDefinition "COVID19NonVentilatedPatientsDexamethasoneApplicationPlan"
Profile: Recommendation Plan
knowledgeCapability: computable
knowledgeRepresentationLevel: structured
partOf: Dexamethasone Application
Action Combination Method
url
method
value: Exactly (Action Combination Method#exactly)
url
threshold
value: 1
url: https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/covid19-non-ventilated-patients-no-dexamethasone-application-plan
version: 4.0
name: No_Dexamethasone_Application
title: No Dexamethasone Application for non-ventilated COVID-19 patients
type: ECA Rule (PlanDefinitionType#eca-rule)
status: ACTIVE
experimental: true
subject: Population_COVID19_NonVentilated
date: 2021-12-12
publisher: CPGonEBMonFHIR
description: No Dexamethasone Application for non-ventilated COVID19 patients
Actions
- Code Definition[x]
* Administration of substance (procedure) (SNOWMED CT#432102000) NoDexamethasoneApplicationActivity

Entry 6 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-oral

Resource ActivityDefinition:

Generated Narrative: ActivityDefinition
ResourceActivityDefinition "DexamethasoneApplicationActionOral"
Profile: Drug Administration Action
knowledgeCapability: computable
knowledgeRepresentationLevel: structured
url: https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-oral
version: 1.0
name: DexamethasoneApplicationActionOral
status: ACTIVE
experimental: true
subject: Patient (All FHIR Types#Patient)
publisher: CPGonEBMonFHIR
description: Application of Dexamethasone: 6 mg once per day for 10 days (oral route)
kind: MEDICATIONREQUEST
code: Administration of substance (procedure) (SNOWMED CT#432102000)
product: Dexamethasone (substance) (SNOWMED CT#372584003; atc#C05AA09 "Dexamethason")
dosage

Entry 7 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-intravenous

Resource ActivityDefinition:

Generated Narrative: ActivityDefinition
ResourceActivityDefinition "DexamethasoneApplicationActionIntravenous"
Profile: Drug Administration Action
knowledgeCapability: computable
knowledgeRepresentationLevel: structured
url: https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/dexamethasone-application-intravenous
version: 1.0
name: DexamethasoneApplicationActionIntravenous
status: ACTIVE
experimental: true
subject: Patient (All FHIR Types#Patient)
publisher: CPGonEBMonFHIR
description: Application of Dexamethasone: 6 mg once per day for 10 days (intravenous route)
kind: MEDICATIONREQUEST
code: Administration of substance (procedure) (SNOWMED CT#432102000)
product: Dexamethasone (substance) (SNOWMED CT#372584003; atc#C05AA09 "Dexamethason")
dosage

Entry 8 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-action-no-application

Resource ActivityDefinition:

Generated Narrative: ActivityDefinition
ResourceActivityDefinition "NoDexamethasoneApplication"
Profile: Drug Administration Action
knowledgeCapability: computable
knowledgeRepresentationLevel: structured
url: https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/no-dexamethasone-application
version: 1.0
name: NoDexamethasoneApplicationActivity
status: ACTIVE
experimental: true
subject: Patient (All FHIR Types#Patient)
publisher: CPGonEBMonFHIR
description: No Application of Dexamethasone
kind: MEDICATIONREQUEST
code: Administration of substance (procedure) (SNOWMED CT#432102000)
doNotPerform: true
product: Dexamethasone (substance) (SNOWMED CT#372584003; atc#C05AA09 "Dexamethason")

Entry 9 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-citation

Resource Citation:

Generated Narrative: Citation
ResourceCitation "DexamethasoneRecommendationCitation"
Profile: Recommendation Citation
name: DexamethasoneRecommendationCitation
status: ACTIVE
citedArtifact
identifier: https://api.magicapp.org/api/v1/recommendations/98398
Versions
- Value
* v4.0
currentState: Active (Cited Artifact Status Type#active)
Titles
- Text
* Steroide
Classifications
- Type Classifier
* Publication Type (Cited Artifact Classification Type#publication-type) Clinical practice guideline recommendation (CEOsys Code System#guideline-recommendation)

Entry 10 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/evidence-variable-ventilated

Resource EvidenceVariable:

Generated Narrative: EvidenceVariable
ResourceEvidenceVariable "PopulationCOVID19Ventilated"
Profile: Recommendation Eligibility Criteria
url: https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_Ventilated
identifier: https://www.ceosys.de/Ventilated
name: Population_COVID19_Ventilated
status: ACTIVE
description: Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, Ventilated
characteristic
linkId: covid19
DefinitionByTypeAndValues
- Type Value[x]
* Clinical finding (finding) (SNOWMED CT#404684003) Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder) (SNOWMED CT#840539006)
characteristic
exclude: false
definitionByCombination
code: ANYOF
characteristic
characteristic
characteristic

Entry 11 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/evidence-variable-non-ventilated

Resource EvidenceVariable:

Generated Narrative: EvidenceVariable
ResourceEvidenceVariable "PopulationCOVID19NonVentilated"
Profile: Recommendation Eligibility Criteria
url: https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/population/Population_COVID19_NonVentilated
identifier: https://www.ceosys.de/NonVentilated
name: Population_COVID19_NonVentilated
status: ACTIVE
description: Population for guideline from https://app.magicapp.org/#/guidelines / 5691 with characteristics: COVID-19, not ventilated
characteristic
linkId: covid19
exclude: false
DefinitionByTypeAndValues
- Type Value[x]
* Clinical finding (finding) (SNOWMED CT#404684003) Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder) (SNOWMED CT#840539006)
characteristic
exclude: true
definitionByCombination
code: ANYOF
characteristic
characteristic
characteristic

Entry 12 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/rating-outcome-mortality

Resource ArtifactAssessment:

Generated Narrative: ArtifactAssessment
ResourceArtifactAssessment "DexamethasoneRatingOutcomeMortality"
Profile: Certainty of Evidence Rating
ArtifactAssessment Version: v4.0
ArtifactAssessment Publication Status: active
date: 2020-01-03
artifact: See on this page: Evidence/DexamethasoneOutcomeMortality
content
informationType: RATING
type: Overall certainty (Evidence Certainty Type#Overall)
classifier: Moderate quality (Evidence Certainty Rating#moderate)
content
informationType: RATING
type: Clinical Importance (CEOsys Code System#clinical-importance)
classifier: Critical (Clinical Importance of Outcome#9)
content
informationType: RATING
type: Risk of bias (Evidence Certainty Type#RiskOfBias)
classifier: serious concern (Evidence Certainty Rating#serious-concern)
content
informationType: RATING
type: Inconsistency (Evidence Certainty Type#Inconsistency)
classifier: no serious concern (Evidence Certainty Rating#no-concern)
content
informationType: RATING
type: Indirectness (Evidence Certainty Type#Indirectness)
classifier: no serious concern (Evidence Certainty Rating#no-concern)
content
informationType: RATING
type: Imprecision (Evidence Certainty Type#Imprecision)
classifier: no serious concern (Evidence Certainty Rating#no-concern)
content
informationType: RATING
type: Publication bias (Evidence Certainty Type#PublicationBias)
classifier: no serious concern (Evidence Certainty Rating#no-concern)

Entry 13 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/outcome-mortality

Resource Evidence:

Generated Narrative: Evidence
ResourceEvidence "DexamethasoneOutcomeMortality"
Profile: Outcome Evidence Synthesis
name: ExampleOutcomeEvidence
status: ACTIVE
RelatedArtifacts
- Type ResourceReference
* CITATION See on this page: Citation/SystemicCorticosteroidsForTheTreatmentOfCOVID19
variableDefinition
variableRole: population (EvidenceVariableRole#population)
observed: Group/StudyCohortCorticosteroidsCOVID19 "StudyCohortCriteriaSystemicCorticosteroidsCOVID19"
intended: See on this page: EvidenceVariable/StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19
variableDefinition
variableRole: measured variable (EvidenceVariableRole#measuredVariable)
observed: See on this page: EvidenceVariable/OutcomeAllCauseMortality
synthesisType: not applicable (SynthesisType#NotApplicable)
statistic
description: Relative effect of intervention vs. comparator
statisticType: Relative Risk (StatisticStatisticType#C93152)
quantity: 0.89
SampleSizes
- NumberOfStudies NumberOfParticipants
* 9 7930
AttributeEstimates
- Type Level Range
* Confidence interval (StatisticAttribute Estimate Type#C53324) 0.95 0.8-1
statistic
description: Baseline risk/result in the comparison group
statisticType: Incidence (StatisticStatisticType#C16726)
quantity: 245 1/1000 (Details: UCUM code 1/1000 = '1/1000')

Entry 14 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/study-eligibility-criteria

Resource EvidenceVariable:

Generated Narrative: EvidenceVariable
ResourceEvidenceVariable "StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19"
Profile: Study Eligibility Criteria
name: StudyEligibilityCriteriaSystemicCorticosteroidsCOVID19
status: ACTIVE
characteristic
DefinitionByTypeAndValues
- Type Value[x]
* Clinical finding (finding) (SNOWMED CT#404684003) Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder) (SNOWMED CT#840539006)

Entry 15 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/outcome-all-cause-mortality

Resource EvidenceVariable:

Generated Narrative: EvidenceVariable
ResourceEvidenceVariable "OutcomeAllCauseMortality"
Profile: Outcome Definition
name: AllCauseMortality
status: ACTIVE
Characteristics
- Exclude DefinitionCodeableConcept
* false Mortality rate (observable entity) (SNOWMED CT#409651001)
handling: DICHOTOMOUS

Entry 16 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/recommendation-justification

Resource ArtifactAssessment:

Generated Narrative: ArtifactAssessment
ResourceArtifactAssessment "DexamethasoneRecommendationJustification"
Profile: Recommendation Justification
ArtifactAssessment Version: v4.0
ArtifactAssessment Publication Status: active
date: 2020-01-03
artifact: See on this page: PlanDefinition/COVID19VentilatedPatientsDexamethasoneApplicationPlan
content
informationType: RATING
type: Strength of recommendation (CEOsys Code System#strength)
classifier: Strong for an intervention (Recommendation Strength#strong-for)
content
informationType: RATING
type: Consensus (CEOsys Code System#consensus)
classifier: Strong (StrengthOfRecommendationRating#strong)
content
informationType: RATING
type: Preference and values (Evidence To Decision Certainty type#preference-and-values)
classifier: Factor not considered (Evidence To Decision Certainty Rating#factor-not-considered)
content
informationType: RATING
type: Resources (Evidence To Decision Certainty type#resources)
classifier: No important issues (Evidence To Decision Certainty Rating#no-important-issues)
content
informationType: RATING
type: Acceptability (Evidence To Decision Certainty type#acceptability)
classifier: Factor not considered (Evidence To Decision Certainty Rating#factor-not-considered)
content
informationType: RATING
type: Feasibility (Evidence To Decision Certainty type#feasibility)
classifier: Factor not considered (Evidence To Decision Certainty Rating#factor-not-considered)
content
informationType: CONTAINER
type: Certainty of evidence rating (CEOsys Code System#certainty-of-evidence-rating)
RelatedArtifacts
- Type Classifier ResourceReference
* JUSTIFICATION Certainty of evidence rating (CEOsys Code System#certainty-of-evidence-rating) See on this page: ArtifactAssessment/DexamethasoneRatingOutcomeMortality

Entry 17 - fullUrl = https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/covid19-intensive-care-treatment/dexamethasone/study-citation

Resource Citation:

Generated Narrative: Citation
ResourceCitation "SystemicCorticosteroidsForTheTreatmentOfCOVID19"
Profile: Study Citation
name: SystemicCorticosteroidsForTheTreatmentOfCOVID19
status: ACTIVE
citedArtifact
identifier: https://pubmed.ncbi.nlm.nih.gov/34396514, https://doi.org/10.1002/14651858.CD014963, https://www.ncbi.nlm.nih.gov/pmc//PMC8406706
Titles
- Text
* Systemic corticosteroids for the treatment of COVID-19
Classifications
- Type Classifier
* Publication Type (Cited Artifact Classification Type#publication-type) Journal Article (Citation Artifact Classifier#D016428)