Clinical Practice Guidelines (CPG) on EBMonFHIR
1.0.2 - qa-preview
This page is part of the CPG-on-EBMonFHIR Implementation Guide (1.0.2).
<Bundle xmlns="http://hl7.org/fhir">
<id value="GuidelineRecommendationExample"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-bundle"/>
</meta>
<type value="collection"/>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example"/>
<resource>
<Composition>
<id value="GuidelineExample"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Composition_GuidelineExample"> </a><p class="res-header-id"><b>Generated Narrative: Composition GuidelineExample</b></p><a name="GuidelineExample"> </a><a name="hcGuidelineExample"> </a><a name="GuidelineExample-en-US"> </a><p><b>identifier</b>: Resource identifier/guideline example</p><p><b>version</b>: 0.1.0</p><p><b>status</b>: Final</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}, {https://data.cochrane.org/concepts/ e07eN1w1Rwswg4}">Guidelines</span></p><p><b>category</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification S3}">Evidence- and consensus-based guideline</span></p><p><b>date</b>: 2022-01-28</p><p><b>author</b>: <a href="Organization-ExampleOrganization.html">Organization Example Organization</a></p><p><b>title</b>: Example Guideline</p><h3>RelatesTos</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><a href="Citation-ExampleGuidelineCitation.html">Citation ExampleGuidelineCitation</a></td></tr></table></div>
</text>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="RI"/>
<display value="Resource identifier"/>
</coding>
</type>
<system value="https://www.ceosys.de"/>
<value value="guideline example"/>
</identifier>
<version value="0.1.0"/>
<status value="final"/>
<type>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="clinical-practice-guideline"/>
</coding>
<coding>
<system value="https://data.cochrane.org/concepts/"/>
<code value="e07eN1w1Rwswg4"/>
<display value="Guidelines"/>
</coding>
</type>
<category>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification"/>
<code value="S3"/>
<display value="Evidence- and consensus-based guideline"/>
</coding>
</category>
<date value="2022-01-28"/>
<author>🔗
<reference value="Organization/ExampleOrganization"/>
</author>
<title value="Example Guideline"/>
<relatesTo>
<type value="citation"/>
<resourceReference>🔗
<reference value="Citation/ExampleGuidelineCitation"/>
</resourceReference>
</relatesTo>
<section>
<title value="Example Guideline Recommendation"/>
<code>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="guideline-recommendation"/>
<display value="Clinical practice guideline recommendation"/>
</coding>
</code>
<focus>🔗
<reference value="PlanDefinition/ExampleRecommendation"/>
</focus>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml">This is an example guideline recommendation.</div>
</text>
</section>
</Composition>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/citation"/>
<resource>
<Citation>
<id value="ExampleGuidelineCitation"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-citation"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Citation_ExampleGuidelineCitation"> </a><p class="res-header-id"><b>Generated Narrative: Citation ExampleGuidelineCitation</b></p><a name="ExampleGuidelineCitation"> </a><a name="hcExampleGuidelineCitation"> </a><a name="ExampleGuidelineCitation-en-US"> </a><p><b>name</b>: ExampleGuidelineCitation</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: ceoysy/exampleIdentifier</p><h3>Versions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Value</b></td></tr><tr><td style="display: none">*</td><td>1.0-alpha1</td></tr></table><p><b>currentState</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-status-type archived}">Archived</span></p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><div><p>Example Citation</p>
</div></td></tr></table><h3>WebLocations</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://example.com/guideline/exampleIdentifier">https://example.com/guideline/exampleIdentifier</a></td></tr></table><h3>Classifications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}">Publication Type</span></td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}">Clinical practice guideline</span></td></tr></table></blockquote></div>
</text>
<name value="ExampleGuidelineCitation"/>
<status value="active"/>
<citedArtifact>
<identifier>
<value value="ceoysy/exampleIdentifier"/>
</identifier>
<version>
<value value="1.0-alpha1"/>
</version>
<currentState>
<coding>
<system value="http://hl7.org/fhir/cited-artifact-status-type"/>
<code value="archived"/>
<display value="Archived"/>
</coding>
</currentState>
<title>
<text value="Example Citation"/>
</title>
<webLocation>
<url value="https://example.com/guideline/exampleIdentifier"/>
</webLocation>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="publication-type"/>
<display value="Publication Type"/>
</coding>
</type>
<classifier>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="clinical-practice-guideline"/>
<display value="Clinical practice guideline"/>
</coding>
</classifier>
</classification>
</citedArtifact>
</Citation>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation"/>
<resource>
<PlanDefinition>
<id value="ExampleRecommendation"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_ExampleRecommendation"> </a><p class="res-header-id"><b>Generated Narrative: PlanDefinition ExampleRecommendation</b></p><a name="ExampleRecommendation"> </a><a name="hcExampleRecommendation"> </a><a name="ExampleRecommendation-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method at-least}">At Least</span></li><li>threshold: 2</li></ul></blockquote><p><b>url</b>: <a href="PlanDefinition-ExampleRecommendation.html">PlanDefinition Recommendation</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: Recommendation</p><p><b>title</b>: Recommendation</p><p><b>type</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type workflow-definition}">Workflow Definition</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>date</b>: 2022-02-14</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Example Recommendation</p>
</div><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Justification</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system recommendation-rating}">Recommendation rating</span></td><td><a href="ArtifactAssessment-ExampleRecommendationJustification.html">ArtifactAssessment: extension = 0.1.0,active; date = 2020-01-03; artifact[x] = ->PlanDefinition Recommendation Plan</a></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system guideline-recommendation}">Clinical practice guideline recommendation</span></td><td><a href="Citation-ExampleRecommendationCitation.html">Citation ExampleRecommendationCitation</a></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}">Clinical practice guideline</span></td><td><a href="Citation-ExampleGuidelineCitation.html">Citation ExampleGuidelineCitation</a></td></tr></table><blockquote><p><b>action</b></p><p><b>title</b>: example recommendation</p><p><b>description</b>: </p><div><p>Example recommendation</p>
</div><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}">Guideline-based Care</span></p><p><b>definition</b>: <a href="PlanDefinition-ExampleRecommendationPlan.html">Recommendation Plan</a></p></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: example recommendation</p><p><b>description</b>: </p><div><p>Example recommendation</p>
</div><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}">Guideline-based Care</span></p><p><b>definition</b>: <a href="PlanDefinition-ExampleRecommendationPlan.html">Recommendation Plan</a></p></blockquote></div>
</text>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
<valueCode value="computable"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
<valueCode value="structured"/>
</extension>
<extension
url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method">
<extension url="method">
<valueCodeableConcept>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method"/>
<code value="at-least"/>
</coding>
</valueCodeableConcept>
</extension>
<extension url="threshold">
<valuePositiveInt value="2"/>
</extension>
</extension>
<url
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation"/>
<version value="1.0"/>
<name value="Recommendation"/>
<title value="Recommendation"/>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
<code value="workflow-definition"/>
</coding>
</type>
<status value="active"/>
<experimental value="true"/>
<date value="2022-02-14"/>
<publisher value="CPGonEBMonFHIR"/>
<description value="Example Recommendation"/>
<relatedArtifact>
<type value="justification"/>
<classifier>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="recommendation-rating"/>
<display value="Recommendation rating"/>
</coding>
</classifier>
<resourceReference>🔗
<reference
value="ArtifactAssessment/ExampleRecommendationJustification"/>
</resourceReference>
</relatedArtifact>
<relatedArtifact>
<type value="citation"/>
<classifier>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="guideline-recommendation"/>
<display value="Clinical practice guideline recommendation"/>
</coding>
</classifier>
<resourceReference>🔗
<reference value="Citation/ExampleRecommendationCitation"/>
</resourceReference>
</relatedArtifact>
<relatedArtifact>
<type value="citation"/>
<classifier>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="clinical-practice-guideline"/>
<display value="Clinical practice guideline"/>
</coding>
</classifier>
<resourceReference>🔗
<reference value="Citation/ExampleGuidelineCitation"/>
</resourceReference>
</relatedArtifact>
<action>
<title value="example recommendation"/>
<description value="Example recommendation"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process"/>
<code value="guideline-based-care"/>
</coding>
</code>
<definitionCanonical
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation-plan"/>
</action>
<action>
<title value="example recommendation"/>
<description value="Example recommendation"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process"/>
<code value="guideline-based-care"/>
</coding>
</code>
<definitionCanonical
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation-plan"/>
</action>
</PlanDefinition>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-plan"/>
<resource>
<PlanDefinition>
<id value="ExampleRecommendationPlan"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_ExampleRecommendationPlan"> </a><p class="res-header-id"><b>Generated Narrative: PlanDefinition ExampleRecommendationPlan</b></p><a name="ExampleRecommendationPlan"> </a><a name="hcExampleRecommendationPlan"> </a><a name="ExampleRecommendationPlan-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href="PlanDefinition-ExampleRecommendation.html">Recommendation</a></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method exactly}">Exactly</span></li><li>threshold: 1</li></ul></blockquote><p><b>url</b>: <a href="PlanDefinition-ExampleRecommendationPlan.html">PlanDefinition Recommendation Plan</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: RecommendationPlan</p><p><b>title</b>: Recommendation Plan</p><p><b>type</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type eca-rule}">ECA Rule</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href="EvidenceVariable-ExampleRecommendationEligibilityCriteria5Levels.html">PopulationExample</a></p><p><b>date</b>: 2022-02-14</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Example Recommendation Plan</p>
</div><blockquote><p><b>goal</b></p><blockquote><p><b>id</b></p>ventilator-management-goal</blockquote><p><b>category</b>: <span title="Codes:{http://snomed.info/sct 385857005}">Ventilator care and adjustment (regime/therapy)</span></p><p><b>description</b>: <span title="Codes:">The ventilator should be set up to provide a breath reate of at least 20 and at most per minute.</span></p><h3>Targets</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Measure</b></td><td><b>Detail[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 33438-3}">Breath rate mechanical --on ventilator</span></td><td>20-24</td></tr></table></blockquote><blockquote><p><b>goal</b></p><blockquote><p><b>id</b></p>lab-ddimer-concentration-goal</blockquote><p><b>category</b>: <span title="Codes:{http://snomed.info/sct 410394004}">Lab findings surveillance (regime/therapy)</span></p><p><b>description</b>: <span title="Codes:">D-Dimer concentration shall be below 250 ng/mL</span></p><h3>Targets</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Measure</b></td><td><b>Detail[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 48066-5}">Fibrin D-dimer DDU [Mass/volume] in Platelet poor plasma</span></td><td>?-250</td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 432102000}">Administration of substance (procedure)</span></p><p><b>definition</b>: <a href="Bundle-GuidelineRecommendationExample.html">DrugAdministrationAction</a></p></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 229824005}">Positioning patient (procedure)</span></p><p><b>goalId</b>: ventilator-management-goal</p><p><b>definition</b>: <a href="ActivityDefinition-ExampleBodyPositioningAction.html">DrugAdministrationAction</a></p></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 410210009}">Ventilator care management (procedure)</span></p><p><b>goalId</b>: ventilator-management-goal</p></blockquote><blockquote><p><b>action</b></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method one-or-more}">One or More</span></li></ul></blockquote><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 89780004}">Combined (qualifier value)</span></p><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>GoalId</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 410210009}">Ventilator care management (procedure)</span></td><td>ventilator-management-goal</td></tr></table></blockquote></div>
</text>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
<valueCode value="computable"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
<valueCode value="structured"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-partOf">
<valueCanonical
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation"/>
</extension>
<extension
url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method">
<extension url="method">
<valueCodeableConcept>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method"/>
<code value="exactly"/>
</coding>
</valueCodeableConcept>
</extension>
<extension url="threshold">
<valuePositiveInt value="1"/>
</extension>
</extension>
<url
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation-plan"/>
<version value="1.0"/>
<name value="RecommendationPlan"/>
<title value="Recommendation Plan"/>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
<code value="eca-rule"/>
</coding>
</type>
<status value="active"/>
<experimental value="true"/>
<subjectCanonical
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-eligibility-criteria"/>
<date value="2022-02-14"/>
<publisher value="CPGonEBMonFHIR"/>
<description value="Example Recommendation Plan"/>
<goal id="ventilator-management-goal">
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="385857005"/>
<display
value="Ventilator care and adjustment (regime/therapy)"/>
</coding>
</category>
<description>
<text
value="The ventilator should be set up to provide a breath reate of at least 20 and at most per minute."/>
</description>
<target>
<measure>
<coding>
<system value="http://loinc.org"/>
<code value="33438-3"/>
<display value="Breath rate mechanical --on ventilator"/>
</coding>
</measure>
<detailRange>
<low>
<value value="20"/>
<system value="http://unitsofmeasure.org"/>
<code value="/min"/>
</low>
<high>
<value value="24"/>
<system value="http://unitsofmeasure.org"/>
<code value="/min"/>
</high>
</detailRange>
</target>
</goal>
<goal id="lab-ddimer-concentration-goal">
<category>
<coding>
<system value="http://snomed.info/sct"/>
<code value="410394004"/>
<display value="Lab findings surveillance (regime/therapy)"/>
</coding>
</category>
<description>
<text value="D-Dimer concentration shall be below 250 ng/mL"/>
</description>
<target>
<measure>
<coding>
<system value="http://loinc.org"/>
<code value="48066-5"/>
<display
value="Fibrin D-dimer DDU [Mass/volume] in Platelet poor plasma"/>
</coding>
</measure>
<detailRange>
<high>
<value value="250"/>
<system value="http://unitsofmeasure.org"/>
<code value="ng/mL"/>
</high>
</detailRange>
</target>
</goal>
<action>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="432102000"/>
<display value="Administration of substance (procedure)"/>
</coding>
</code>
<definitionCanonical
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/drug-administration-example"/>
</action>
<action>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="229824005"/>
<display value="Positioning patient (procedure)"/>
</coding>
</code>
<goalId value="ventilator-management-goal"/>
<definitionCanonical
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/body-positioning-example"/>
</action>
<action>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="410210009"/>
<display value="Ventilator care management (procedure)"/>
</coding>
</code>
<goalId value="ventilator-management-goal"/>
</action>
<action>
<extension
url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method">
<extension url="method">
<valueCodeableConcept>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method"/>
<code value="one-or-more"/>
</coding>
</valueCodeableConcept>
</extension>
</extension>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="89780004"/>
<display value="Combined (qualifier value)"/>
</coding>
</code>
<action>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="410210009"/>
<display value="Ventilator care management (procedure)"/>
</coding>
</code>
<goalId value="ventilator-management-goal"/>
</action>
</action>
</PlanDefinition>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-action"/>
<resource>
<ActivityDefinition>
<id value="ExampleDrugAdministrationAction"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ActivityDefinition_ExampleDrugAdministrationAction"> </a><p class="res-header-id"><b>Generated Narrative: ActivityDefinition ExampleDrugAdministrationAction</b></p><a name="ExampleDrugAdministrationAction"> </a><a name="hcExampleDrugAdministrationAction"> </a><a name="ExampleDrugAdministrationAction-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href="ActivityDefinition-ExampleDrugAdministrationAction.html">ActivityDefinition DrugAdministrationAction</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: DrugAdministrationAction</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title="Codes:{http://hl7.org/fhir/fhir-types Patient}">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>A drug administration that should be performed.</p>
</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 432102000}">Administration of substance (procedure)</span></p><p><b>product</b>: <span title="Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}">Dexamethasone (substance)</span></p><blockquote><p><b>dosage</b></p><blockquote><p><b>Dosage Condition</b></p><ul><li>type: <span title="Codes:{http://loinc.org 29463-7}">Body weight</span></li><li>value: ?-70</li></ul></blockquote><p><b>timing</b>: Count 10 times, Duration 10days , Once per 1 days</p><p><b>route</b>: <span title="Codes:{http://snomed.info/sct 26643006}">Oral route</span></p><h3>DoseAndRates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Dose[x]</b></td><td><b>Rate[x]</b></td></tr><tr><td style="display: none">*</td><td>6 mg<span style="background: LightGoldenRodYellow"> (Details: UCUM codemg = 'mg')</span></td><td>1 /d<span style="background: LightGoldenRodYellow"> (Details: UCUM code/d = '/d')</span></td></tr></table></blockquote></div>
</text>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
<valueCode value="computable"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
<valueCode value="structured"/>
</extension>
<url
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/drug-administration-example"/>
<version value="1.0"/>
<name value="DrugAdministrationAction"/>
<status value="active"/>
<experimental value="true"/>
<subjectCodeableConcept>
<coding>
<system value="http://hl7.org/fhir/fhir-types"/>
<code value="Patient"/>
</coding>
</subjectCodeableConcept>
<publisher value="CPGonEBMonFHIR"/>
<description value="A drug administration that should be performed."/>
<kind value="MedicationRequest"/>
<code>
<coding>
<system value="http://snomed.info/sct"/>
<code value="432102000"/>
<display value="Administration of substance (procedure)"/>
</coding>
</code>
<productCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="372584003"/>
<display value="Dexamethasone (substance)"/>
</coding>
<coding>
<system value="http://fhir.de/CodeSystem/bfarm/atc"/>
<code value="C05AA09"/>
<display value="Dexamethason"/>
</coding>
</productCodeableConcept>
<dosage>
<extension
url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-dosage-condition">
<extension url="type">
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="29463-7"/>
<display value="Body weight"/>
</coding>
</valueCodeableConcept>
</extension>
<extension url="value">
<valueRange>
<high>
<value value="70"/>
<unit value="kg"/>
<system value="http://unitsofmeasure.org"/>
<code value="kg"/>
</high>
</valueRange>
</extension>
</extension>
<timing>
<repeat>
<count value="10"/>
<duration value="10"/>
<durationUnit value="d"/>
<frequency value="1"/>
<period value="1"/>
<periodUnit value="d"/>
</repeat>
</timing>
<route>
<coding>
<system value="http://snomed.info/sct"/>
<code value="26643006"/>
<display value="Oral route"/>
</coding>
</route>
<doseAndRate>
<doseQuantity>
<value value="6"/>
<unit value="mg"/>
<system value="http://unitsofmeasure.org"/>
<code value="mg"/>
</doseQuantity>
<rateQuantity>
<value value="1"/>
<unit value="/d"/>
<system value="http://unitsofmeasure.org"/>
<code value="/d"/>
</rateQuantity>
</doseAndRate>
</dosage>
</ActivityDefinition>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/population"/>
<resource>
<EvidenceVariable>
<id value="ExampleRecommendationEligibilityCriteria"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-eligibility-criteria"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_ExampleRecommendationEligibilityCriteria"> </a><p class="res-header-id"><b>Generated Narrative: EvidenceVariable ExampleRecommendationEligibilityCriteria</b></p><a name="ExampleRecommendationEligibilityCriteria"> </a><a name="hcExampleRecommendationEligibilityCriteria"> </a><a name="ExampleRecommendationEligibilityCriteria-en-US"> </a><p><b>url</b>: <a href="EvidenceVariable-ExampleRecommendationEligibilityCriteria.html">EvidenceVariable PopulationExample</a></p><p><b>name</b>: PopulationExample</p><p><b>status</b>: Active</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 404684003}">Clinical finding (finding)</span></td><td><span title="Codes:{http://snomed.info/sct 840539006}">Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)</span></td></tr></table></blockquote></div>
</text>
<url
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-eligibility-criteria"/>
<name value="PopulationExample"/>
<status value="active"/>
<characteristic>
<definitionByTypeAndValue>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="404684003"/>
<display value="Clinical finding (finding)"/>
</coding>
</type>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="840539006"/>
<display
value="Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"/>
</coding>
</valueCodeableConcept>
</definitionByTypeAndValue>
</characteristic>
</EvidenceVariable>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-justification"/>
<resource>
<ArtifactAssessment>
<id value="ExampleRecommendationJustification"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-justification"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ArtifactAssessment_ExampleRecommendationJustification"> </a><p class="res-header-id"><b>Generated Narrative: ArtifactAssessment ExampleRecommendationJustification</b></p><a name="ExampleRecommendationJustification"> </a><a name="hcExampleRecommendationJustification"> </a><a name="ExampleRecommendationJustification-en-US"> </a><p><b>ArtifactAssessment Version</b>: 0.1.0</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2020-01-03</p><p><b>artifact</b>: <a href="PlanDefinition-ExampleRecommendationPlan.html">PlanDefinition Recommendation Plan</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system strength}">Strength of recommendation</span></p><p><b>classifier</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-cs-recommendation-strength strong-for}">Strong for an intervention</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Overall}">Overall certainty</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating very-low}">Very low quality</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system consensus}">Consensus</span></p><p><b>classifier</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/recommendation-strength strong}">Strong</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Container</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system certainty-of-evidence-rating}">Certainty of evidence rating</span></p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Justification</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system certainty-of-evidence-rating}">Certainty of evidence rating</span></td><td><a href="ArtifactAssessment-ExampleCertaintyOfEvidenceRating.html">ArtifactAssessment: extension = 0.1.1,active; date = 2022-03-11; artifact[x] = ->Evidence ExampleStudyOutcomeEvidence</a></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Container</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system net-effect}">Net effect</span></p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Supported With</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system net-effect}">Net effect</span></td><td><a href="Evidence-ExampleNetEffectEstimate.html">Evidence NetEffectExample</a></td></tr></table></blockquote></div>
</text>
<extension
url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-version">
<valueString value="0.1.0"/>
</extension>
<extension
url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-publication-status">
<valueCode value="active"/>
</extension>
<date value="2020-01-03"/>
<artifactReference>🔗
<reference value="PlanDefinition/ExampleRecommendationPlan"/>
</artifactReference>
<content>
<informationType value="rating"/>
<type>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="strength"/>
<display value="Strength of recommendation"/>
</coding>
</type>
<classifier>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-cs-recommendation-strength"/>
<code value="strong-for"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="Overall"/>
<display value="Overall certainty"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="very-low"/>
<display value="Very low quality"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="consensus"/>
<display value="Consensus"/>
</coding>
</type>
<classifier>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/recommendation-strength"/>
<code value="strong"/>
<display value="Strong"/>
</coding>
</classifier>
</content>
<content>
<informationType value="container"/>
<type>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="certainty-of-evidence-rating"/>
<display value="Certainty of evidence rating"/>
</coding>
</type>
<relatedArtifact>
<type value="justification"/>
<classifier>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="certainty-of-evidence-rating"/>
<display value="Certainty of evidence rating"/>
</coding>
</classifier>
<resourceReference>🔗
<reference
value="ArtifactAssessment/ExampleCertaintyOfEvidenceRating"/>
</resourceReference>
</relatedArtifact>
</content>
<content>
<informationType value="container"/>
<type>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="net-effect"/>
<display value="Net effect"/>
</coding>
</type>
<relatedArtifact>
<type value="supported-with"/>
<classifier>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="net-effect"/>
<display value="Net effect"/>
</coding>
</classifier>
<resourceReference>🔗
<reference value="Evidence/ExampleNetEffectEstimate"/>
</resourceReference>
</relatedArtifact>
</content>
</ArtifactAssessment>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/certainty-of-evidence-rating"/>
<resource>
<ArtifactAssessment>
<id value="ExampleCertaintyOfEvidenceRating"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/certainty-of-evidence-rating"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ArtifactAssessment_ExampleCertaintyOfEvidenceRating"> </a><p class="res-header-id"><b>Generated Narrative: ArtifactAssessment ExampleCertaintyOfEvidenceRating</b></p><a name="ExampleCertaintyOfEvidenceRating"> </a><a name="hcExampleCertaintyOfEvidenceRating"> </a><a name="ExampleCertaintyOfEvidenceRating-en-US"> </a><p><b>ArtifactAssessment Version</b>: 0.1.1</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2022-03-11</p><p><b>artifact</b>: <a href="Evidence-ExampleStudyOutcomeEvidence.html">Evidence ExampleStudyOutcomeEvidence</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Overall}">Overall certainty</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating moderate}">Moderate quality</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type RiskOfBias}">Risk of bias</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating serious-concern}">serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Imprecision}">Imprecision</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating serious-concern}">serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type LargeEffect}">Large effect</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating upcode2}">increase rating: +2</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type PlausibleConfounding}">Plausible confounding</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating upcode1}">increase rating: +1</span></p></blockquote></div>
</text>
<extension
url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-version">
<valueString value="0.1.1"/>
</extension>
<extension
url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-publication-status">
<valueCode value="active"/>
</extension>
<date value="2022-03-11"/>
<artifactReference>🔗
<reference value="Evidence/ExampleStudyOutcomeEvidence"/>
</artifactReference>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="Overall"/>
<display value="Overall certainty"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="moderate"/>
<display value="Moderate quality"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="RiskOfBias"/>
<display value="Risk of bias"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="serious-concern"/>
<display value="serious concern"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="Imprecision"/>
<display value="Imprecision"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="serious-concern"/>
<display value="serious concern"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="LargeEffect"/>
<display value="Large effect"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="upcode2"/>
<display value="increase rating: +2"/>
</coding>
</classifier>
</content>
<content>
<informationType value="rating"/>
<type>
<coding>
<system value="http://hl7.org/fhir/certainty-type"/>
<code value="PlausibleConfounding"/>
<display value="Plausible confounding"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/certainty-rating"/>
<code value="upcode1"/>
<display value="increase rating: +1"/>
</coding>
</classifier>
</content>
</ArtifactAssessment>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/study-outcome-evidence"/>
<resource>
<Evidence>
<id value="ExampleStudyOutcomeEvidence"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-outcome-evidence"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Evidence_ExampleStudyOutcomeEvidence"> </a><p class="res-header-id"><b>Generated Narrative: Evidence ExampleStudyOutcomeEvidence</b></p><a name="ExampleStudyOutcomeEvidence"> </a><a name="hcExampleStudyOutcomeEvidence"> </a><a name="ExampleStudyOutcomeEvidence-en-US"> </a><p><b>name</b>: ExampleStudyOutcomeEvidence</p><p><b>status</b>: Active</p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><a href="Citation-ExampleStudyCitation.html">Citation ExampleCitation</a></td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role population}">population</span></p><p><b>observed</b>: <a href="Group-ExampleStudyCohort.html">Group: type = person; membership = definitional; quantity = 20</a></p><p><b>intended</b>: <a href="EvidenceVariable-ExampleStudyEligibilityCriteria.html">EvidenceVariable ExampleStudyEligibilityCriteria</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}">measured variable</span></p><p><b>observed</b>: <a href="EvidenceVariable-ExampleOutcome.html">EvidenceVariable Mortality</a></p></blockquote><p><b>synthesisType</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/synthesis-type NotApplicable}">not applicable</span></p></div>
</text>
<name value="ExampleStudyOutcomeEvidence"/>
<status value="active"/>
<relatedArtifact>
<type value="citation"/>
<resourceReference>🔗
<reference value="Citation/ExampleStudyCitation"/>
</resourceReference>
</relatedArtifact>
<variableDefinition>
<variableRole>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/variable-role"/>
<code value="population"/>
</coding>
</variableRole>
<observed>🔗
<reference value="Group/ExampleStudyCohort"/>
</observed>
<intended>🔗
<reference
value="EvidenceVariable/ExampleStudyEligibilityCriteria"/>
</intended>
</variableDefinition>
<variableDefinition>
<variableRole>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/variable-role"/>
<code value="measuredVariable"/>
</coding>
</variableRole>
<observed>🔗
<reference value="EvidenceVariable/ExampleOutcome"/>
</observed>
</variableDefinition>
<synthesisType>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/synthesis-type"/>
<code value="NotApplicable"/>
</coding>
</synthesisType>
</Evidence>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/outcome-evidence-synthesis"/>
<resource>
<Evidence>
<id value="ExampleOutcomeEvidenceSynthesis"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-evidence-synthesis"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Evidence_ExampleOutcomeEvidenceSynthesis"> </a><p class="res-header-id"><b>Generated Narrative: Evidence ExampleOutcomeEvidenceSynthesis</b></p><a name="ExampleOutcomeEvidenceSynthesis"> </a><a name="hcExampleOutcomeEvidenceSynthesis"> </a><a name="ExampleOutcomeEvidenceSynthesis-en-US"> </a><p><b>name</b>: ExampleOutcomeEvidenceSynthesis</p><p><b>status</b>: Active</p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><a href="Citation-ExampleStudyCitation.html">Citation ExampleCitation</a></td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role population}">population</span></p><p><b>observed</b>: <a href="Group-ExampleEvidenceSynthesisCohorts.html">Group: type = person; membership = definitional; quantity = 20</a></p><p><b>intended</b>: <a href="EvidenceVariable-ExampleStudyEligibilityCriteria.html">EvidenceVariable ExampleStudyEligibilityCriteria</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}">measured variable</span></p><p><b>observed</b>: <a href="EvidenceVariable-ExampleOutcome.html">EvidenceVariable Mortality</a></p></blockquote><p><b>synthesisType</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/synthesis-type NotApplicable}">not applicable</span></p></div>
</text>
<name value="ExampleOutcomeEvidenceSynthesis"/>
<status value="active"/>
<relatedArtifact>
<type value="citation"/>
<resourceReference>🔗
<reference value="Citation/ExampleStudyCitation"/>
</resourceReference>
</relatedArtifact>
<variableDefinition>
<variableRole>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/variable-role"/>
<code value="population"/>
</coding>
</variableRole>
<observed>🔗
<reference value="Group/ExampleEvidenceSynthesisCohorts"/>
</observed>
<intended>🔗
<reference
value="EvidenceVariable/ExampleStudyEligibilityCriteria"/>
</intended>
</variableDefinition>
<variableDefinition>
<variableRole>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/variable-role"/>
<code value="measuredVariable"/>
</coding>
</variableRole>
<observed>🔗
<reference value="EvidenceVariable/ExampleOutcome"/>
</observed>
</variableDefinition>
<synthesisType>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/synthesis-type"/>
<code value="NotApplicable"/>
</coding>
</synthesisType>
</Evidence>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/study-eligbility-criteria"/>
<resource>
<EvidenceVariable>
<id value="ExampleStudyEligibilityCriteria"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-eligibility-criteria"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_ExampleStudyEligibilityCriteria"> </a><p class="res-header-id"><b>Generated Narrative: EvidenceVariable ExampleStudyEligibilityCriteria</b></p><a name="ExampleStudyEligibilityCriteria"> </a><a name="hcExampleStudyEligibilityCriteria"> </a><a name="ExampleStudyEligibilityCriteria-en-US"> </a><p><b>name</b>: ExampleStudyEligibilityCriteria</p><p><b>status</b>: Active</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 404684003}">Clinical finding (finding)</span></td><td><span title="Codes:{http://snomed.info/sct 840539006}">Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)</span></td></tr></table></blockquote></div>
</text>
<name value="ExampleStudyEligibilityCriteria"/>
<status value="active"/>
<characteristic>
<definitionByTypeAndValue>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="404684003"/>
<display value="Clinical finding (finding)"/>
</coding>
</type>
<valueCodeableConcept>
<coding>
<system value="http://snomed.info/sct"/>
<code value="840539006"/>
<display
value="Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"/>
</coding>
</valueCodeableConcept>
</definitionByTypeAndValue>
</characteristic>
</EvidenceVariable>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/study-citation"/>
<resource>
<Citation>
<id value="ExampleStudyCitation"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-citation"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Citation_ExampleStudyCitation"> </a><p class="res-header-id"><b>Generated Narrative: Citation ExampleStudyCitation</b></p><a name="ExampleStudyCitation"> </a><a name="hcExampleStudyCitation"> </a><a name="ExampleStudyCitation-en-US"> </a><p><b>name</b>: ExampleCitation</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: ceoysy/exampleIdentifier</p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><div><p>Example Citation</p>
</div></td></tr></table><h3>Classifications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}">Publication Type</span></td><td><span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></td></tr></table></blockquote></div>
</text>
<name value="ExampleCitation"/>
<status value="active"/>
<citedArtifact>
<identifier>
<value value="ceoysy/exampleIdentifier"/>
</identifier>
<title>
<text value="Example Citation"/>
</title>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="publication-type"/>
<display value="Publication Type"/>
</coding>
</type>
<classifier>
<coding>
<system
value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
</classification>
</citedArtifact>
</Citation>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/outcome"/>
<resource>
<EvidenceVariable>
<id value="ExampleOutcome"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-definition"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_ExampleOutcome"> </a><p class="res-header-id"><b>Generated Narrative: EvidenceVariable ExampleOutcome</b></p><a name="ExampleOutcome"> </a><a name="hcExampleOutcome"> </a><a name="ExampleOutcome-en-US"> </a><p><b>identifier</b>: <code>https://www.ceosys.de</code>/outcome-example</p><p><b>name</b>: Mortality</p><p><b>status</b>: Active</p><blockquote><p><b>characteristic</b></p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 409651001}">Mortality rate (observable entity)</span></td><td> percent<span style="background: LightGoldenRodYellow"> (Details: UCUM code% = '%')</span></td></tr></table></blockquote><p><b>handling</b>: dichotomous variable</p></div>
</text>
<identifier>
<system value="https://www.ceosys.de"/>
<value value="outcome-example"/>
</identifier>
<name value="Mortality"/>
<status value="active"/>
<characteristic>
<exclude value="false"/>
<definitionByTypeAndValue>
<type>
<coding>
<system value="http://snomed.info/sct"/>
<code value="409651001"/>
<display value="Mortality rate (observable entity)"/>
</coding>
</type>
<valueQuantity>
<unit value="percent"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
</definitionByTypeAndValue>
</characteristic>
<handling value="dichotomous"/>
</EvidenceVariable>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-citation"/>
<resource>
<Citation>
<id value="ExampleRecommendationCitation"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-citation"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Citation_ExampleRecommendationCitation"> </a><p class="res-header-id"><b>Generated Narrative: Citation ExampleRecommendationCitation</b></p><a name="ExampleRecommendationCitation"> </a><a name="hcExampleRecommendationCitation"> </a><a name="ExampleRecommendationCitation-en-US"> </a><p><b>name</b>: ExampleRecommendationCitation</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: ceoysy/exampleIdentifier</p><h3>Versions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Value</b></td></tr><tr><td style="display: none">*</td><td>1.0-alpha1</td></tr></table><p><b>currentState</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-status-type archived}">Archived</span></p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><div><p>Example Citation</p>
</div></td></tr></table><h3>Classifications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}">Publication Type</span></td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system guideline-recommendation}">Clinical practice guideline recommendation</span></td></tr></table></blockquote></div>
</text>
<name value="ExampleRecommendationCitation"/>
<status value="active"/>
<citedArtifact>
<identifier>
<value value="ceoysy/exampleIdentifier"/>
</identifier>
<version>
<value value="1.0-alpha1"/>
</version>
<currentState>
<coding>
<system value="http://hl7.org/fhir/cited-artifact-status-type"/>
<code value="archived"/>
<display value="Archived"/>
</coding>
</currentState>
<title>
<text value="Example Citation"/>
</title>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="publication-type"/>
<display value="Publication Type"/>
</coding>
</type>
<classifier>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="guideline-recommendation"/>
<display value="Clinical practice guideline recommendation"/>
</coding>
</classifier>
</classification>
</citedArtifact>
</Citation>
</resource>
</entry>
<entry>
<fullUrl
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/net-effect-estimate"/>
<resource>
<Evidence>
<id value="ExampleNetEffectEstimate"/>
<meta>
<profile
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/net-effect-estimate"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Evidence_ExampleNetEffectEstimate"> </a><p class="res-header-id"><b>Generated Narrative: Evidence ExampleNetEffectEstimate</b></p><a name="ExampleNetEffectEstimate"> </a><a name="hcExampleNetEffectEstimate"> </a><a name="ExampleNetEffectEstimate-en-US"> </a><p><b>name</b>: NetEffectExample</p><p><b>status</b>: Unknown</p><h3>VariableDefinitions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>VariableRole</b></td><td><b>Intended</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}">measured variable</span></td><td><a href="EvidenceVariable-ExampleOutcome.html">EvidenceVariable Mortality</a></td></tr></table><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>Net Effect</p>
</div><p><b>statisticType</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system net-effect}">Net Effect</span></p><p><b>quantity</b>: 1.7 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code% = '%')</span></p><h3>AttributeEstimates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://terminology.hl7.org/CodeSystem/attribute-estimate-type C53324}">Confidence interval</span></td><td>0.95</td><td>1.5-1.9</td></tr></table><blockquote><p><b>modelCharacteristic</b></p><p><b>code</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system relative-importance-weighting}">Relative importance weighting for use in weighted linear combinations</span></p><p><b>value</b>: 1</p><h3>Variables</h3><table class="grid"><tr><td style="display: none">-</td><td><b>VariableDefinition</b></td></tr><tr><td style="display: none">*</td><td><a href="EvidenceVariable-ExampleOutcome.html">EvidenceVariable Mortality</a></td></tr></table></blockquote></blockquote></div>
</text>
<name value="NetEffectExample"/>
<status value="unknown"/>
<variableDefinition>
<variableRole>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/variable-role"/>
<code value="measuredVariable"/>
</coding>
</variableRole>
<intended>🔗
<reference value="EvidenceVariable/ExampleOutcome"/>
</intended>
</variableDefinition>
<statistic>
<description value="Net Effect"/>
<statisticType>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="net-effect"/>
<display value="Net Effect"/>
</coding>
</statisticType>
<quantity>
<value value="1.7"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</quantity>
<attributeEstimate>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/attribute-estimate-type"/>
<code value="C53324"/>
<display value="Confidence interval"/>
</coding>
</type>
<level value="0.95"/>
<range>
<low>
<value value="1.5"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</low>
<high>
<value value="1.9"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</high>
</range>
</attributeEstimate>
<modelCharacteristic>
<code>
<coding>
<system
value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
<code value="relative-importance-weighting"/>
</coding>
</code>
<value>
<value value="1"/>
</value>
<variable>
<variableDefinition>🔗
<reference value="EvidenceVariable/ExampleOutcome"/>
</variableDefinition>
</variable>
</modelCharacteristic>
</statistic>
</Evidence>
</resource>
</entry>
</Bundle>