Clinical Practice Guidelines (CPG) on EBMonFHIR
1.0.2 - qa-preview

This page is part of the CPG-on-EBMonFHIR Implementation Guide (1.0.2).

: Guideline Recommendation Example - XML Representation

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<Bundle xmlns="http://hl7.org/fhir">
  <id value="GuidelineRecommendationExample"/>
  <meta>
    <profile
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-bundle"/>
  </meta>
  <type value="collection"/>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example"/>
    <resource>
      <Composition>
        <id value="GuidelineExample"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Composition_GuidelineExample"> </a><p class="res-header-id"><b>Generated Narrative: Composition GuidelineExample</b></p><a name="GuidelineExample"> </a><a name="hcGuidelineExample"> </a><a name="GuidelineExample-en-US"> </a><p><b>identifier</b>: Resource identifier/guideline example</p><p><b>version</b>: 0.1.0</p><p><b>status</b>: Final</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}, {https://data.cochrane.org/concepts/ e07eN1w1Rwswg4}">Guidelines</span></p><p><b>category</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification S3}">Evidence- and consensus-based guideline</span></p><p><b>date</b>: 2022-01-28</p><p><b>author</b>: <a href="Organization-ExampleOrganization.html">Organization Example Organization</a></p><p><b>title</b>: Example Guideline</p><h3>RelatesTos</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><a href="Citation-ExampleGuidelineCitation.html">Citation ExampleGuidelineCitation</a></td></tr></table></div>
        </text>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="RI"/>
              <display value="Resource identifier"/>
            </coding>
          </type>
          <system value="https://www.ceosys.de"/>
          <value value="guideline example"/>
        </identifier>
        <version value="0.1.0"/>
        <status value="final"/>
        <type>
          <coding>
            <system
                    value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
            <code value="clinical-practice-guideline"/>
          </coding>
          <coding>
            <system value="https://data.cochrane.org/concepts/"/>
            <code value="e07eN1w1Rwswg4"/>
            <display value="Guidelines"/>
          </coding>
        </type>
        <category>
          <coding>
            <system
                    value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification"/>
            <code value="S3"/>
            <display value="Evidence- and consensus-based guideline"/>
          </coding>
        </category>
        <date value="2022-01-28"/>
        <author>🔗 
          <reference value="Organization/ExampleOrganization"/>
        </author>
        <title value="Example Guideline"/>
        <relatesTo>
          <type value="citation"/>
          <resourceReference>🔗 
            <reference value="Citation/ExampleGuidelineCitation"/>
          </resourceReference>
        </relatesTo>
        <section>
          <title value="Example Guideline Recommendation"/>
          <code>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="guideline-recommendation"/>
              <display value="Clinical practice guideline recommendation"/>
            </coding>
          </code>
          <focus>🔗 
            <reference value="PlanDefinition/ExampleRecommendation"/>
          </focus>
          <text>
            <status value="generated"/>
            <div xmlns="http://www.w3.org/1999/xhtml">This is an example guideline recommendation.</div>
          </text>
        </section>
      </Composition>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/citation"/>
    <resource>
      <Citation>
        <id value="ExampleGuidelineCitation"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-citation"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Citation_ExampleGuidelineCitation"> </a><p class="res-header-id"><b>Generated Narrative: Citation ExampleGuidelineCitation</b></p><a name="ExampleGuidelineCitation"> </a><a name="hcExampleGuidelineCitation"> </a><a name="ExampleGuidelineCitation-en-US"> </a><p><b>name</b>: ExampleGuidelineCitation</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: ceoysy/exampleIdentifier</p><h3>Versions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Value</b></td></tr><tr><td style="display: none">*</td><td>1.0-alpha1</td></tr></table><p><b>currentState</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-status-type archived}">Archived</span></p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><div><p>Example Citation</p>
</div></td></tr></table><h3>WebLocations</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://example.com/guideline/exampleIdentifier">https://example.com/guideline/exampleIdentifier</a></td></tr></table><h3>Classifications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}">Publication Type</span></td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}">Clinical practice guideline</span></td></tr></table></blockquote></div>
        </text>
        <name value="ExampleGuidelineCitation"/>
        <status value="active"/>
        <citedArtifact>
          <identifier>
            <value value="ceoysy/exampleIdentifier"/>
          </identifier>
          <version>
            <value value="1.0-alpha1"/>
          </version>
          <currentState>
            <coding>
              <system value="http://hl7.org/fhir/cited-artifact-status-type"/>
              <code value="archived"/>
              <display value="Archived"/>
            </coding>
          </currentState>
          <title>
            <text value="Example Citation"/>
          </title>
          <webLocation>
            <url value="https://example.com/guideline/exampleIdentifier"/>
          </webLocation>
          <classification>
            <type>
              <coding>
                <system
                        value="http://hl7.org/fhir/cited-artifact-classification-type"/>
                <code value="publication-type"/>
                <display value="Publication Type"/>
              </coding>
            </type>
            <classifier>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
                <code value="clinical-practice-guideline"/>
                <display value="Clinical practice guideline"/>
              </coding>
            </classifier>
          </classification>
        </citedArtifact>
      </Citation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation"/>
    <resource>
      <PlanDefinition>
        <id value="ExampleRecommendation"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_ExampleRecommendation"> </a><p class="res-header-id"><b>Generated Narrative: PlanDefinition ExampleRecommendation</b></p><a name="ExampleRecommendation"> </a><a name="hcExampleRecommendation"> </a><a name="ExampleRecommendation-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method at-least}">At Least</span></li><li>threshold: 2</li></ul></blockquote><p><b>url</b>: <a href="PlanDefinition-ExampleRecommendation.html">PlanDefinition Recommendation</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: Recommendation</p><p><b>title</b>: Recommendation</p><p><b>type</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type workflow-definition}">Workflow Definition</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>date</b>: 2022-02-14</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Example Recommendation</p>
</div><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Justification</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system recommendation-rating}">Recommendation rating</span></td><td><a href="ArtifactAssessment-ExampleRecommendationJustification.html">ArtifactAssessment: extension = 0.1.0,active; date = 2020-01-03; artifact[x] = -&gt;PlanDefinition Recommendation Plan</a></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system guideline-recommendation}">Clinical practice guideline recommendation</span></td><td><a href="Citation-ExampleRecommendationCitation.html">Citation ExampleRecommendationCitation</a></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}">Clinical practice guideline</span></td><td><a href="Citation-ExampleGuidelineCitation.html">Citation ExampleGuidelineCitation</a></td></tr></table><blockquote><p><b>action</b></p><p><b>title</b>: example recommendation</p><p><b>description</b>: </p><div><p>Example recommendation</p>
</div><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}">Guideline-based Care</span></p><p><b>definition</b>: <a href="PlanDefinition-ExampleRecommendationPlan.html">Recommendation Plan</a></p></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: example recommendation</p><p><b>description</b>: </p><div><p>Example recommendation</p>
</div><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}">Guideline-based Care</span></p><p><b>definition</b>: <a href="PlanDefinition-ExampleRecommendationPlan.html">Recommendation Plan</a></p></blockquote></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
          <valueCode value="computable"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
          <valueCode value="structured"/>
        </extension>
        <extension
                   url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method">
          <extension url="method">
            <valueCodeableConcept>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method"/>
                <code value="at-least"/>
              </coding>
            </valueCodeableConcept>
          </extension>
          <extension url="threshold">
            <valuePositiveInt value="2"/>
          </extension>
        </extension>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation"/>
        <version value="1.0"/>
        <name value="Recommendation"/>
        <title value="Recommendation"/>
        <type>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
            <code value="workflow-definition"/>
          </coding>
        </type>
        <status value="active"/>
        <experimental value="true"/>
        <date value="2022-02-14"/>
        <publisher value="CPGonEBMonFHIR"/>
        <description value="Example Recommendation"/>
        <relatedArtifact>
          <type value="justification"/>
          <classifier>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="recommendation-rating"/>
              <display value="Recommendation rating"/>
            </coding>
          </classifier>
          <resourceReference>🔗 
            <reference
                       value="ArtifactAssessment/ExampleRecommendationJustification"/>
          </resourceReference>
        </relatedArtifact>
        <relatedArtifact>
          <type value="citation"/>
          <classifier>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="guideline-recommendation"/>
              <display value="Clinical practice guideline recommendation"/>
            </coding>
          </classifier>
          <resourceReference>🔗 
            <reference value="Citation/ExampleRecommendationCitation"/>
          </resourceReference>
        </relatedArtifact>
        <relatedArtifact>
          <type value="citation"/>
          <classifier>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="clinical-practice-guideline"/>
              <display value="Clinical practice guideline"/>
            </coding>
          </classifier>
          <resourceReference>🔗 
            <reference value="Citation/ExampleGuidelineCitation"/>
          </resourceReference>
        </relatedArtifact>
        <action>
          <title value="example recommendation"/>
          <description value="Example recommendation"/>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process"/>
              <code value="guideline-based-care"/>
            </coding>
          </code>
          <definitionCanonical
                               value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation-plan"/>
        </action>
        <action>
          <title value="example recommendation"/>
          <description value="Example recommendation"/>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process"/>
              <code value="guideline-based-care"/>
            </coding>
          </code>
          <definitionCanonical
                               value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation-plan"/>
        </action>
      </PlanDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-plan"/>
    <resource>
      <PlanDefinition>
        <id value="ExampleRecommendationPlan"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_ExampleRecommendationPlan"> </a><p class="res-header-id"><b>Generated Narrative: PlanDefinition ExampleRecommendationPlan</b></p><a name="ExampleRecommendationPlan"> </a><a name="hcExampleRecommendationPlan"> </a><a name="ExampleRecommendationPlan-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href="PlanDefinition-ExampleRecommendation.html">Recommendation</a></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method exactly}">Exactly</span></li><li>threshold: 1</li></ul></blockquote><p><b>url</b>: <a href="PlanDefinition-ExampleRecommendationPlan.html">PlanDefinition Recommendation Plan</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: RecommendationPlan</p><p><b>title</b>: Recommendation Plan</p><p><b>type</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type eca-rule}">ECA Rule</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href="EvidenceVariable-ExampleRecommendationEligibilityCriteria5Levels.html">PopulationExample</a></p><p><b>date</b>: 2022-02-14</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Example Recommendation Plan</p>
</div><blockquote><p><b>goal</b></p><blockquote><p><b>id</b></p>ventilator-management-goal</blockquote><p><b>category</b>: <span title="Codes:{http://snomed.info/sct 385857005}">Ventilator care and adjustment (regime/therapy)</span></p><p><b>description</b>: <span title="Codes:">The ventilator should be set up to provide a breath reate of at least 20 and at most per minute.</span></p><h3>Targets</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Measure</b></td><td><b>Detail[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 33438-3}">Breath rate mechanical --on ventilator</span></td><td>20-24</td></tr></table></blockquote><blockquote><p><b>goal</b></p><blockquote><p><b>id</b></p>lab-ddimer-concentration-goal</blockquote><p><b>category</b>: <span title="Codes:{http://snomed.info/sct 410394004}">Lab findings surveillance (regime/therapy)</span></p><p><b>description</b>: <span title="Codes:">D-Dimer concentration shall be below 250 ng/mL</span></p><h3>Targets</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Measure</b></td><td><b>Detail[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 48066-5}">Fibrin D-dimer DDU [Mass/volume] in Platelet poor plasma</span></td><td>?-250</td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 432102000}">Administration of substance (procedure)</span></p><p><b>definition</b>: <a href="Bundle-GuidelineRecommendationExample.html">DrugAdministrationAction</a></p></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 229824005}">Positioning patient (procedure)</span></p><p><b>goalId</b>: ventilator-management-goal</p><p><b>definition</b>: <a href="ActivityDefinition-ExampleBodyPositioningAction.html">DrugAdministrationAction</a></p></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 410210009}">Ventilator care management (procedure)</span></p><p><b>goalId</b>: ventilator-management-goal</p></blockquote><blockquote><p><b>action</b></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method one-or-more}">One or More</span></li></ul></blockquote><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 89780004}">Combined (qualifier value)</span></p><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>GoalId</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 410210009}">Ventilator care management (procedure)</span></td><td>ventilator-management-goal</td></tr></table></blockquote></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
          <valueCode value="computable"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
          <valueCode value="structured"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-partOf">
          <valueCanonical
                          value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation"/>
        </extension>
        <extension
                   url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method">
          <extension url="method">
            <valueCodeableConcept>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method"/>
                <code value="exactly"/>
              </coding>
            </valueCodeableConcept>
          </extension>
          <extension url="threshold">
            <valuePositiveInt value="1"/>
          </extension>
        </extension>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation-plan"/>
        <version value="1.0"/>
        <name value="RecommendationPlan"/>
        <title value="Recommendation Plan"/>
        <type>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
            <code value="eca-rule"/>
          </coding>
        </type>
        <status value="active"/>
        <experimental value="true"/>
        <subjectCanonical
                          value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-eligibility-criteria"/>
        <date value="2022-02-14"/>
        <publisher value="CPGonEBMonFHIR"/>
        <description value="Example Recommendation Plan"/>
        <goal id="ventilator-management-goal">
          <category>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="385857005"/>
              <display
                       value="Ventilator care and adjustment (regime/therapy)"/>
            </coding>
          </category>
          <description>
            <text
                  value="The ventilator should be set up to provide a breath reate of at least 20 and at most per minute."/>
          </description>
          <target>
            <measure>
              <coding>
                <system value="http://loinc.org"/>
                <code value="33438-3"/>
                <display value="Breath rate mechanical --on ventilator"/>
              </coding>
            </measure>
            <detailRange>
              <low>
                <value value="20"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="/min"/>
              </low>
              <high>
                <value value="24"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="/min"/>
              </high>
            </detailRange>
          </target>
        </goal>
        <goal id="lab-ddimer-concentration-goal">
          <category>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="410394004"/>
              <display value="Lab findings surveillance (regime/therapy)"/>
            </coding>
          </category>
          <description>
            <text value="D-Dimer concentration shall be below 250 ng/mL"/>
          </description>
          <target>
            <measure>
              <coding>
                <system value="http://loinc.org"/>
                <code value="48066-5"/>
                <display
                         value="Fibrin D-dimer DDU [Mass/volume] in Platelet poor plasma"/>
              </coding>
            </measure>
            <detailRange>
              <high>
                <value value="250"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="ng/mL"/>
              </high>
            </detailRange>
          </target>
        </goal>
        <action>
          <code>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="432102000"/>
              <display value="Administration of substance (procedure)"/>
            </coding>
          </code>
          <definitionCanonical
                               value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/drug-administration-example"/>
        </action>
        <action>
          <code>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="229824005"/>
              <display value="Positioning patient (procedure)"/>
            </coding>
          </code>
          <goalId value="ventilator-management-goal"/>
          <definitionCanonical
                               value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/body-positioning-example"/>
        </action>
        <action>
          <code>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="410210009"/>
              <display value="Ventilator care management (procedure)"/>
            </coding>
          </code>
          <goalId value="ventilator-management-goal"/>
        </action>
        <action>
          <extension
                     url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method">
            <extension url="method">
              <valueCodeableConcept>
                <coding>
                  <system
                          value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method"/>
                  <code value="one-or-more"/>
                </coding>
              </valueCodeableConcept>
            </extension>
          </extension>
          <code>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="89780004"/>
              <display value="Combined (qualifier value)"/>
            </coding>
          </code>
          <action>
            <code>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="410210009"/>
                <display value="Ventilator care management (procedure)"/>
              </coding>
            </code>
            <goalId value="ventilator-management-goal"/>
          </action>
        </action>
      </PlanDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-action"/>
    <resource>
      <ActivityDefinition>
        <id value="ExampleDrugAdministrationAction"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ActivityDefinition_ExampleDrugAdministrationAction"> </a><p class="res-header-id"><b>Generated Narrative: ActivityDefinition ExampleDrugAdministrationAction</b></p><a name="ExampleDrugAdministrationAction"> </a><a name="hcExampleDrugAdministrationAction"> </a><a name="ExampleDrugAdministrationAction-en-US"> </a><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href="ActivityDefinition-ExampleDrugAdministrationAction.html">ActivityDefinition DrugAdministrationAction</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: DrugAdministrationAction</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title="Codes:{http://hl7.org/fhir/fhir-types Patient}">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>A drug administration that should be performed.</p>
</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title="Codes:{http://snomed.info/sct 432102000}">Administration of substance (procedure)</span></p><p><b>product</b>: <span title="Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}">Dexamethasone (substance)</span></p><blockquote><p><b>dosage</b></p><blockquote><p><b>Dosage Condition</b></p><ul><li>type: <span title="Codes:{http://loinc.org 29463-7}">Body weight</span></li><li>value: ?-70</li></ul></blockquote><p><b>timing</b>: Count 10  times, Duration 10days , Once per 1 days</p><p><b>route</b>: <span title="Codes:{http://snomed.info/sct 26643006}">Oral route</span></p><h3>DoseAndRates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Dose[x]</b></td><td><b>Rate[x]</b></td></tr><tr><td style="display: none">*</td><td>6 mg<span style="background: LightGoldenRodYellow"> (Details: UCUM  codemg = 'mg')</span></td><td>1 /d<span style="background: LightGoldenRodYellow"> (Details: UCUM  code/d = '/d')</span></td></tr></table></blockquote></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability">
          <valueCode value="computable"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel">
          <valueCode value="structured"/>
        </extension>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/drug-administration-example"/>
        <version value="1.0"/>
        <name value="DrugAdministrationAction"/>
        <status value="active"/>
        <experimental value="true"/>
        <subjectCodeableConcept>
          <coding>
            <system value="http://hl7.org/fhir/fhir-types"/>
            <code value="Patient"/>
          </coding>
        </subjectCodeableConcept>
        <publisher value="CPGonEBMonFHIR"/>
        <description value="A drug administration that should be performed."/>
        <kind value="MedicationRequest"/>
        <code>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="432102000"/>
            <display value="Administration of substance (procedure)"/>
          </coding>
        </code>
        <productCodeableConcept>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="372584003"/>
            <display value="Dexamethasone (substance)"/>
          </coding>
          <coding>
            <system value="http://fhir.de/CodeSystem/bfarm/atc"/>
            <code value="C05AA09"/>
            <display value="Dexamethason"/>
          </coding>
        </productCodeableConcept>
        <dosage>
          <extension
                     url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-dosage-condition">
            <extension url="type">
              <valueCodeableConcept>
                <coding>
                  <system value="http://loinc.org"/>
                  <code value="29463-7"/>
                  <display value="Body weight"/>
                </coding>
              </valueCodeableConcept>
            </extension>
            <extension url="value">
              <valueRange>
                <high>
                  <value value="70"/>
                  <unit value="kg"/>
                  <system value="http://unitsofmeasure.org"/>
                  <code value="kg"/>
                </high>
              </valueRange>
            </extension>
          </extension>
          <timing>
            <repeat>
              <count value="10"/>
              <duration value="10"/>
              <durationUnit value="d"/>
              <frequency value="1"/>
              <period value="1"/>
              <periodUnit value="d"/>
            </repeat>
          </timing>
          <route>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="26643006"/>
              <display value="Oral route"/>
            </coding>
          </route>
          <doseAndRate>
            <doseQuantity>
              <value value="6"/>
              <unit value="mg"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="mg"/>
            </doseQuantity>
            <rateQuantity>
              <value value="1"/>
              <unit value="/d"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="/d"/>
            </rateQuantity>
          </doseAndRate>
        </dosage>
      </ActivityDefinition>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/population"/>
    <resource>
      <EvidenceVariable>
        <id value="ExampleRecommendationEligibilityCriteria"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-eligibility-criteria"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_ExampleRecommendationEligibilityCriteria"> </a><p class="res-header-id"><b>Generated Narrative: EvidenceVariable ExampleRecommendationEligibilityCriteria</b></p><a name="ExampleRecommendationEligibilityCriteria"> </a><a name="hcExampleRecommendationEligibilityCriteria"> </a><a name="ExampleRecommendationEligibilityCriteria-en-US"> </a><p><b>url</b>: <a href="EvidenceVariable-ExampleRecommendationEligibilityCriteria.html">EvidenceVariable PopulationExample</a></p><p><b>name</b>: PopulationExample</p><p><b>status</b>: Active</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 404684003}">Clinical finding (finding)</span></td><td><span title="Codes:{http://snomed.info/sct 840539006}">Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)</span></td></tr></table></blockquote></div>
        </text>
        <url
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-eligibility-criteria"/>
        <name value="PopulationExample"/>
        <status value="active"/>
        <characteristic>
          <definitionByTypeAndValue>
            <type>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="404684003"/>
                <display value="Clinical finding (finding)"/>
              </coding>
            </type>
            <valueCodeableConcept>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="840539006"/>
                <display
                         value="Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"/>
              </coding>
            </valueCodeableConcept>
          </definitionByTypeAndValue>
        </characteristic>
      </EvidenceVariable>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-justification"/>
    <resource>
      <ArtifactAssessment>
        <id value="ExampleRecommendationJustification"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-justification"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ArtifactAssessment_ExampleRecommendationJustification"> </a><p class="res-header-id"><b>Generated Narrative: ArtifactAssessment ExampleRecommendationJustification</b></p><a name="ExampleRecommendationJustification"> </a><a name="hcExampleRecommendationJustification"> </a><a name="ExampleRecommendationJustification-en-US"> </a><p><b>ArtifactAssessment Version</b>: 0.1.0</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2020-01-03</p><p><b>artifact</b>: <a href="PlanDefinition-ExampleRecommendationPlan.html">PlanDefinition Recommendation Plan</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system strength}">Strength of recommendation</span></p><p><b>classifier</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-cs-recommendation-strength strong-for}">Strong for an intervention</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Overall}">Overall certainty</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating very-low}">Very low quality</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system consensus}">Consensus</span></p><p><b>classifier</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/recommendation-strength strong}">Strong</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Container</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system certainty-of-evidence-rating}">Certainty of evidence rating</span></p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Justification</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system certainty-of-evidence-rating}">Certainty of evidence rating</span></td><td><a href="ArtifactAssessment-ExampleCertaintyOfEvidenceRating.html">ArtifactAssessment: extension = 0.1.1,active; date = 2022-03-11; artifact[x] = -&gt;Evidence ExampleStudyOutcomeEvidence</a></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Container</p><p><b>type</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system net-effect}">Net effect</span></p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Supported With</td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system net-effect}">Net effect</span></td><td><a href="Evidence-ExampleNetEffectEstimate.html">Evidence NetEffectExample</a></td></tr></table></blockquote></div>
        </text>
        <extension
                   url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-version">
          <valueString value="0.1.0"/>
        </extension>
        <extension
                   url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-publication-status">
          <valueCode value="active"/>
        </extension>
        <date value="2020-01-03"/>
        <artifactReference>🔗 
          <reference value="PlanDefinition/ExampleRecommendationPlan"/>
        </artifactReference>
        <content>
          <informationType value="rating"/>
          <type>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="strength"/>
              <display value="Strength of recommendation"/>
            </coding>
          </type>
          <classifier>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-cs-recommendation-strength"/>
              <code value="strong-for"/>
            </coding>
          </classifier>
        </content>
        <content>
          <informationType value="rating"/>
          <type>
            <coding>
              <system value="http://hl7.org/fhir/certainty-type"/>
              <code value="Overall"/>
              <display value="Overall certainty"/>
            </coding>
          </type>
          <classifier>
            <coding>
              <system value="http://hl7.org/fhir/certainty-rating"/>
              <code value="very-low"/>
              <display value="Very low quality"/>
            </coding>
          </classifier>
        </content>
        <content>
          <informationType value="rating"/>
          <type>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="consensus"/>
              <display value="Consensus"/>
            </coding>
          </type>
          <classifier>
            <coding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/recommendation-strength"/>
              <code value="strong"/>
              <display value="Strong"/>
            </coding>
          </classifier>
        </content>
        <content>
          <informationType value="container"/>
          <type>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="certainty-of-evidence-rating"/>
              <display value="Certainty of evidence rating"/>
            </coding>
          </type>
          <relatedArtifact>
            <type value="justification"/>
            <classifier>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
                <code value="certainty-of-evidence-rating"/>
                <display value="Certainty of evidence rating"/>
              </coding>
            </classifier>
            <resourceReference>🔗 
              <reference
                         value="ArtifactAssessment/ExampleCertaintyOfEvidenceRating"/>
            </resourceReference>
          </relatedArtifact>
        </content>
        <content>
          <informationType value="container"/>
          <type>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="net-effect"/>
              <display value="Net effect"/>
            </coding>
          </type>
          <relatedArtifact>
            <type value="supported-with"/>
            <classifier>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
                <code value="net-effect"/>
                <display value="Net effect"/>
              </coding>
            </classifier>
            <resourceReference>🔗 
              <reference value="Evidence/ExampleNetEffectEstimate"/>
            </resourceReference>
          </relatedArtifact>
        </content>
      </ArtifactAssessment>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/certainty-of-evidence-rating"/>
    <resource>
      <ArtifactAssessment>
        <id value="ExampleCertaintyOfEvidenceRating"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/certainty-of-evidence-rating"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ArtifactAssessment_ExampleCertaintyOfEvidenceRating"> </a><p class="res-header-id"><b>Generated Narrative: ArtifactAssessment ExampleCertaintyOfEvidenceRating</b></p><a name="ExampleCertaintyOfEvidenceRating"> </a><a name="hcExampleCertaintyOfEvidenceRating"> </a><a name="ExampleCertaintyOfEvidenceRating-en-US"> </a><p><b>ArtifactAssessment Version</b>: 0.1.1</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2022-03-11</p><p><b>artifact</b>: <a href="Evidence-ExampleStudyOutcomeEvidence.html">Evidence ExampleStudyOutcomeEvidence</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Overall}">Overall certainty</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating moderate}">Moderate quality</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type RiskOfBias}">Risk of bias</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating serious-concern}">serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Imprecision}">Imprecision</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating serious-concern}">serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type LargeEffect}">Large effect</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating upcode2}">increase rating: +2</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type PlausibleConfounding}">Plausible confounding</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating upcode1}">increase rating: +1</span></p></blockquote></div>
        </text>
        <extension
                   url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-version">
          <valueString value="0.1.1"/>
        </extension>
        <extension
                   url="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-publication-status">
          <valueCode value="active"/>
        </extension>
        <date value="2022-03-11"/>
        <artifactReference>🔗 
          <reference value="Evidence/ExampleStudyOutcomeEvidence"/>
        </artifactReference>
        <content>
          <informationType value="rating"/>
          <type>
            <coding>
              <system value="http://hl7.org/fhir/certainty-type"/>
              <code value="Overall"/>
              <display value="Overall certainty"/>
            </coding>
          </type>
          <classifier>
            <coding>
              <system value="http://hl7.org/fhir/certainty-rating"/>
              <code value="moderate"/>
              <display value="Moderate quality"/>
            </coding>
          </classifier>
        </content>
        <content>
          <informationType value="rating"/>
          <type>
            <coding>
              <system value="http://hl7.org/fhir/certainty-type"/>
              <code value="RiskOfBias"/>
              <display value="Risk of bias"/>
            </coding>
          </type>
          <classifier>
            <coding>
              <system value="http://hl7.org/fhir/certainty-rating"/>
              <code value="serious-concern"/>
              <display value="serious concern"/>
            </coding>
          </classifier>
        </content>
        <content>
          <informationType value="rating"/>
          <type>
            <coding>
              <system value="http://hl7.org/fhir/certainty-type"/>
              <code value="Imprecision"/>
              <display value="Imprecision"/>
            </coding>
          </type>
          <classifier>
            <coding>
              <system value="http://hl7.org/fhir/certainty-rating"/>
              <code value="serious-concern"/>
              <display value="serious concern"/>
            </coding>
          </classifier>
        </content>
        <content>
          <informationType value="rating"/>
          <type>
            <coding>
              <system value="http://hl7.org/fhir/certainty-type"/>
              <code value="LargeEffect"/>
              <display value="Large effect"/>
            </coding>
          </type>
          <classifier>
            <coding>
              <system value="http://hl7.org/fhir/certainty-rating"/>
              <code value="upcode2"/>
              <display value="increase rating: +2"/>
            </coding>
          </classifier>
        </content>
        <content>
          <informationType value="rating"/>
          <type>
            <coding>
              <system value="http://hl7.org/fhir/certainty-type"/>
              <code value="PlausibleConfounding"/>
              <display value="Plausible confounding"/>
            </coding>
          </type>
          <classifier>
            <coding>
              <system value="http://hl7.org/fhir/certainty-rating"/>
              <code value="upcode1"/>
              <display value="increase rating: +1"/>
            </coding>
          </classifier>
        </content>
      </ArtifactAssessment>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/study-outcome-evidence"/>
    <resource>
      <Evidence>
        <id value="ExampleStudyOutcomeEvidence"/>
        <meta>
          <profile
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        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Evidence_ExampleStudyOutcomeEvidence"> </a><p class="res-header-id"><b>Generated Narrative: Evidence ExampleStudyOutcomeEvidence</b></p><a name="ExampleStudyOutcomeEvidence"> </a><a name="hcExampleStudyOutcomeEvidence"> </a><a name="ExampleStudyOutcomeEvidence-en-US"> </a><p><b>name</b>: ExampleStudyOutcomeEvidence</p><p><b>status</b>: Active</p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><a href="Citation-ExampleStudyCitation.html">Citation ExampleCitation</a></td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role population}">population</span></p><p><b>observed</b>: <a href="Group-ExampleStudyCohort.html">Group: type = person; membership = definitional; quantity = 20</a></p><p><b>intended</b>: <a href="EvidenceVariable-ExampleStudyEligibilityCriteria.html">EvidenceVariable ExampleStudyEligibilityCriteria</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}">measured variable</span></p><p><b>observed</b>: <a href="EvidenceVariable-ExampleOutcome.html">EvidenceVariable Mortality</a></p></blockquote><p><b>synthesisType</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/synthesis-type NotApplicable}">not applicable</span></p></div>
        </text>
        <name value="ExampleStudyOutcomeEvidence"/>
        <status value="active"/>
        <relatedArtifact>
          <type value="citation"/>
          <resourceReference>🔗 
            <reference value="Citation/ExampleStudyCitation"/>
          </resourceReference>
        </relatedArtifact>
        <variableDefinition>
          <variableRole>
            <coding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/variable-role"/>
              <code value="population"/>
            </coding>
          </variableRole>
          <observed>🔗 
            <reference value="Group/ExampleStudyCohort"/>
          </observed>
          <intended>🔗 
            <reference
                       value="EvidenceVariable/ExampleStudyEligibilityCriteria"/>
          </intended>
        </variableDefinition>
        <variableDefinition>
          <variableRole>
            <coding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/variable-role"/>
              <code value="measuredVariable"/>
            </coding>
          </variableRole>
          <observed>🔗 
            <reference value="EvidenceVariable/ExampleOutcome"/>
          </observed>
        </variableDefinition>
        <synthesisType>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/synthesis-type"/>
            <code value="NotApplicable"/>
          </coding>
        </synthesisType>
      </Evidence>
    </resource>
  </entry>
  <entry>
    <fullUrl
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    <resource>
      <Evidence>
        <id value="ExampleOutcomeEvidenceSynthesis"/>
        <meta>
          <profile
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        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Evidence_ExampleOutcomeEvidenceSynthesis"> </a><p class="res-header-id"><b>Generated Narrative: Evidence ExampleOutcomeEvidenceSynthesis</b></p><a name="ExampleOutcomeEvidenceSynthesis"> </a><a name="hcExampleOutcomeEvidenceSynthesis"> </a><a name="ExampleOutcomeEvidenceSynthesis-en-US"> </a><p><b>name</b>: ExampleOutcomeEvidenceSynthesis</p><p><b>status</b>: Active</p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><a href="Citation-ExampleStudyCitation.html">Citation ExampleCitation</a></td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role population}">population</span></p><p><b>observed</b>: <a href="Group-ExampleEvidenceSynthesisCohorts.html">Group: type = person; membership = definitional; quantity = 20</a></p><p><b>intended</b>: <a href="EvidenceVariable-ExampleStudyEligibilityCriteria.html">EvidenceVariable ExampleStudyEligibilityCriteria</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}">measured variable</span></p><p><b>observed</b>: <a href="EvidenceVariable-ExampleOutcome.html">EvidenceVariable Mortality</a></p></blockquote><p><b>synthesisType</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/synthesis-type NotApplicable}">not applicable</span></p></div>
        </text>
        <name value="ExampleOutcomeEvidenceSynthesis"/>
        <status value="active"/>
        <relatedArtifact>
          <type value="citation"/>
          <resourceReference>🔗 
            <reference value="Citation/ExampleStudyCitation"/>
          </resourceReference>
        </relatedArtifact>
        <variableDefinition>
          <variableRole>
            <coding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/variable-role"/>
              <code value="population"/>
            </coding>
          </variableRole>
          <observed>🔗 
            <reference value="Group/ExampleEvidenceSynthesisCohorts"/>
          </observed>
          <intended>🔗 
            <reference
                       value="EvidenceVariable/ExampleStudyEligibilityCriteria"/>
          </intended>
        </variableDefinition>
        <variableDefinition>
          <variableRole>
            <coding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/variable-role"/>
              <code value="measuredVariable"/>
            </coding>
          </variableRole>
          <observed>🔗 
            <reference value="EvidenceVariable/ExampleOutcome"/>
          </observed>
        </variableDefinition>
        <synthesisType>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/synthesis-type"/>
            <code value="NotApplicable"/>
          </coding>
        </synthesisType>
      </Evidence>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/study-eligbility-criteria"/>
    <resource>
      <EvidenceVariable>
        <id value="ExampleStudyEligibilityCriteria"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-eligibility-criteria"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_ExampleStudyEligibilityCriteria"> </a><p class="res-header-id"><b>Generated Narrative: EvidenceVariable ExampleStudyEligibilityCriteria</b></p><a name="ExampleStudyEligibilityCriteria"> </a><a name="hcExampleStudyEligibilityCriteria"> </a><a name="ExampleStudyEligibilityCriteria-en-US"> </a><p><b>name</b>: ExampleStudyEligibilityCriteria</p><p><b>status</b>: Active</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 404684003}">Clinical finding (finding)</span></td><td><span title="Codes:{http://snomed.info/sct 840539006}">Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)</span></td></tr></table></blockquote></div>
        </text>
        <name value="ExampleStudyEligibilityCriteria"/>
        <status value="active"/>
        <characteristic>
          <definitionByTypeAndValue>
            <type>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="404684003"/>
                <display value="Clinical finding (finding)"/>
              </coding>
            </type>
            <valueCodeableConcept>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="840539006"/>
                <display
                         value="Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"/>
              </coding>
            </valueCodeableConcept>
          </definitionByTypeAndValue>
        </characteristic>
      </EvidenceVariable>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/study-citation"/>
    <resource>
      <Citation>
        <id value="ExampleStudyCitation"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-citation"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Citation_ExampleStudyCitation"> </a><p class="res-header-id"><b>Generated Narrative: Citation ExampleStudyCitation</b></p><a name="ExampleStudyCitation"> </a><a name="hcExampleStudyCitation"> </a><a name="ExampleStudyCitation-en-US"> </a><p><b>name</b>: ExampleCitation</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: ceoysy/exampleIdentifier</p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><div><p>Example Citation</p>
</div></td></tr></table><h3>Classifications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}">Publication Type</span></td><td><span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></td></tr></table></blockquote></div>
        </text>
        <name value="ExampleCitation"/>
        <status value="active"/>
        <citedArtifact>
          <identifier>
            <value value="ceoysy/exampleIdentifier"/>
          </identifier>
          <title>
            <text value="Example Citation"/>
          </title>
          <classification>
            <type>
              <coding>
                <system
                        value="http://hl7.org/fhir/cited-artifact-classification-type"/>
                <code value="publication-type"/>
                <display value="Publication Type"/>
              </coding>
            </type>
            <classifier>
              <coding>
                <system
                        value="http://hl7.org/fhir/citation-artifact-classifier"/>
                <code value="D016428"/>
                <display value="Journal Article"/>
              </coding>
            </classifier>
          </classification>
        </citedArtifact>
      </Citation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/outcome"/>
    <resource>
      <EvidenceVariable>
        <id value="ExampleOutcome"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-definition"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="EvidenceVariable_ExampleOutcome"> </a><p class="res-header-id"><b>Generated Narrative: EvidenceVariable ExampleOutcome</b></p><a name="ExampleOutcome"> </a><a name="hcExampleOutcome"> </a><a name="ExampleOutcome-en-US"> </a><p><b>identifier</b>: <code>https://www.ceosys.de</code>/outcome-example</p><p><b>name</b>: Mortality</p><p><b>status</b>: Active</p><blockquote><p><b>characteristic</b></p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://snomed.info/sct 409651001}">Mortality rate (observable entity)</span></td><td> percent<span style="background: LightGoldenRodYellow"> (Details: UCUM  code% = '%')</span></td></tr></table></blockquote><p><b>handling</b>: dichotomous variable</p></div>
        </text>
        <identifier>
          <system value="https://www.ceosys.de"/>
          <value value="outcome-example"/>
        </identifier>
        <name value="Mortality"/>
        <status value="active"/>
        <characteristic>
          <exclude value="false"/>
          <definitionByTypeAndValue>
            <type>
              <coding>
                <system value="http://snomed.info/sct"/>
                <code value="409651001"/>
                <display value="Mortality rate (observable entity)"/>
              </coding>
            </type>
            <valueQuantity>
              <unit value="percent"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="%"/>
            </valueQuantity>
          </definitionByTypeAndValue>
        </characteristic>
        <handling value="dichotomous"/>
      </EvidenceVariable>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-citation"/>
    <resource>
      <Citation>
        <id value="ExampleRecommendationCitation"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-citation"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Citation_ExampleRecommendationCitation"> </a><p class="res-header-id"><b>Generated Narrative: Citation ExampleRecommendationCitation</b></p><a name="ExampleRecommendationCitation"> </a><a name="hcExampleRecommendationCitation"> </a><a name="ExampleRecommendationCitation-en-US"> </a><p><b>name</b>: ExampleRecommendationCitation</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: ceoysy/exampleIdentifier</p><h3>Versions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Value</b></td></tr><tr><td style="display: none">*</td><td>1.0-alpha1</td></tr></table><p><b>currentState</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-status-type archived}">Archived</span></p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><div><p>Example Citation</p>
</div></td></tr></table><h3>Classifications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}">Publication Type</span></td><td><span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system guideline-recommendation}">Clinical practice guideline recommendation</span></td></tr></table></blockquote></div>
        </text>
        <name value="ExampleRecommendationCitation"/>
        <status value="active"/>
        <citedArtifact>
          <identifier>
            <value value="ceoysy/exampleIdentifier"/>
          </identifier>
          <version>
            <value value="1.0-alpha1"/>
          </version>
          <currentState>
            <coding>
              <system value="http://hl7.org/fhir/cited-artifact-status-type"/>
              <code value="archived"/>
              <display value="Archived"/>
            </coding>
          </currentState>
          <title>
            <text value="Example Citation"/>
          </title>
          <classification>
            <type>
              <coding>
                <system
                        value="http://hl7.org/fhir/cited-artifact-classification-type"/>
                <code value="publication-type"/>
                <display value="Publication Type"/>
              </coding>
            </type>
            <classifier>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
                <code value="guideline-recommendation"/>
                <display value="Clinical practice guideline recommendation"/>
              </coding>
            </classifier>
          </classification>
        </citedArtifact>
      </Citation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/net-effect-estimate"/>
    <resource>
      <Evidence>
        <id value="ExampleNetEffectEstimate"/>
        <meta>
          <profile
                   value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/net-effect-estimate"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Evidence_ExampleNetEffectEstimate"> </a><p class="res-header-id"><b>Generated Narrative: Evidence ExampleNetEffectEstimate</b></p><a name="ExampleNetEffectEstimate"> </a><a name="hcExampleNetEffectEstimate"> </a><a name="ExampleNetEffectEstimate-en-US"> </a><p><b>name</b>: NetEffectExample</p><p><b>status</b>: Unknown</p><h3>VariableDefinitions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>VariableRole</b></td><td><b>Intended</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}">measured variable</span></td><td><a href="EvidenceVariable-ExampleOutcome.html">EvidenceVariable Mortality</a></td></tr></table><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>Net Effect</p>
</div><p><b>statisticType</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system net-effect}">Net Effect</span></p><p><b>quantity</b>: 1.7 %<span style="background: LightGoldenRodYellow"> (Details: UCUM  code% = '%')</span></p><h3>AttributeEstimates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://terminology.hl7.org/CodeSystem/attribute-estimate-type C53324}">Confidence interval</span></td><td>0.95</td><td>1.5-1.9</td></tr></table><blockquote><p><b>modelCharacteristic</b></p><p><b>code</b>: <span title="Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system relative-importance-weighting}">Relative importance weighting for use in weighted linear combinations</span></p><p><b>value</b>: 1</p><h3>Variables</h3><table class="grid"><tr><td style="display: none">-</td><td><b>VariableDefinition</b></td></tr><tr><td style="display: none">*</td><td><a href="EvidenceVariable-ExampleOutcome.html">EvidenceVariable Mortality</a></td></tr></table></blockquote></blockquote></div>
        </text>
        <name value="NetEffectExample"/>
        <status value="unknown"/>
        <variableDefinition>
          <variableRole>
            <coding>
              <system
                      value="http://terminology.hl7.org/CodeSystem/variable-role"/>
              <code value="measuredVariable"/>
            </coding>
          </variableRole>
          <intended>🔗 
            <reference value="EvidenceVariable/ExampleOutcome"/>
          </intended>
        </variableDefinition>
        <statistic>
          <description value="Net Effect"/>
          <statisticType>
            <coding>
              <system
                      value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
              <code value="net-effect"/>
              <display value="Net Effect"/>
            </coding>
          </statisticType>
          <quantity>
            <value value="1.7"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="%"/>
          </quantity>
          <attributeEstimate>
            <type>
              <coding>
                <system
                        value="http://terminology.hl7.org/CodeSystem/attribute-estimate-type"/>
                <code value="C53324"/>
                <display value="Confidence interval"/>
              </coding>
            </type>
            <level value="0.95"/>
            <range>
              <low>
                <value value="1.5"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="%"/>
              </low>
              <high>
                <value value="1.9"/>
                <system value="http://unitsofmeasure.org"/>
                <code value="%"/>
              </high>
            </range>
          </attributeEstimate>
          <modelCharacteristic>
            <code>
              <coding>
                <system
                        value="https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system"/>
                <code value="relative-importance-weighting"/>
              </coding>
            </code>
            <value>
              <value value="1"/>
            </value>
            <variable>
              <variableDefinition>🔗 
                <reference value="EvidenceVariable/ExampleOutcome"/>
              </variableDefinition>
            </variable>
          </modelCharacteristic>
        </statistic>
      </Evidence>
    </resource>
  </entry>
</Bundle>